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Neurophysiological evaluation of acoustic startle response in children with autism spectrum disorders

Research Project

Project/Area Number 23890257
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research Institution独立行政法人国立精神・神経医療研究センター

Principal Investigator

TAKAHASHI Hidetoshi  独立行政法人国立精神・神経医療研究センター, 精神保健研究所・児童・思春期精神保健研究部, 児童期精神保健研究室長 (40423222)

Project Period (FY) 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords神経科学 / 生理学 / 脳神経 / 自閉症 / 驚愕反射 / 脳・神経
Research Abstract

Acoustic startle response(ASR) was examined in Japanese children with autism spectrum disorders(ASD) and in Japanese children with typical development(TD). Compared to TD group, ASD group showed longer latency and larger response to weak acoustic stimuli. And, the latency of ASR negatively correlated with social cognition, and, the response to weak stimuli also negatively to prosocial behavior. Profile of ASR was related with ASD feature, and, further studies of ASR in ASD including evaluation of startle modulation, such as prepulse inhibition, are expected to clarify the neurophysiological mechanism of ASD.

Report

(2 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (13 results)

All 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 3 results) Presentation (5 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Relationship of prepulse inhibition to temperament and character in healthy Japanese subjects2012

    • Author(s)
      Takahashi H, Iwase M, Yasuda Y, Ohi K, Fukumoto M, Iike N, Yamamori H, Nakahachi T, Ikezawa K, Azechi M, Canuet L, Ishii R, Kazui H, Hashimoto R, Takeda M
    • Journal Title

      Neurosci Res

      Volume: 72(2) Issue: 2 Pages: 187-193

    • DOI

      10.1016/j.neures.2011.10.009

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 東日本大震災における児童・思春期精神医学的支援活動について2012

    • Author(s)
      高橋秀俊,長尾圭造,神尾陽子
    • Journal Title

      精神保健研究

      Volume: 58 Pages: 43-48

    • URL

      http://www.ncnp.go.jp/nimh/index.html

    • Related Report
      2011 Final Research Report
  • [Journal Article] レジリエンスに対応する生理的指標2012

    • Author(s)
      岩瀬真生、石井良平、栗本龍、高橋秀俊、中鉢貴行、武田雅俊
    • Journal Title

      臨床精神医学

      Volume: 41(2) Pages: 135-141

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Prepulse Inhibition of Startle Response : Recent Advances in Human Studies of Psychiatric Disease2011

    • Author(s)
      Takahashi H, Hashimoto R, Iwase M, Ishii R, Kamio Y, Takeda M
    • Journal Title

      Clinical Psychopharmacology and Neuroscience

      Volume: 9(3) Pages: 102-1102

    • URL

      http://pdf.medrang.co.kr/Cpn/2011/009/Cpn009-03-02.pdf

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prepulse Inhibition of Startle Response : Recent Advances in Human Studies of Psychiatric Disease2011

    • Author(s)
      Takahashi H, et al
    • Journal Title

      Clinical Psychopharmacology and Neuroscience

      Volume: 9(3) Pages: 102-110

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 日本人の自閉症スペクトラム児における聴覚性驚愕反射に関する研究2012

    • Author(s)
      高橋秀俊,中鉢貴行,井口英子,森脇愛子,稲田尚子,武井麗子,神尾陽子
    • Organizer
      国立精神・神経医療研究センター精神保健研究所平成23年度研究報告会(第23回)
    • Place of Presentation
      国立精神・神経医療研究センター,東京都小平市
    • Year and Date
      2012-02-27
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 神経生理機能・人格傾向とゲノム2011

    • Author(s)
      高橋秀俊
    • Organizer
      第二回脳表現型の分子メカニズム研究会チュートリアルコース:ゲノムを用いた脳表現型のトランスレーショナルリサーチ,東京大学医学部教育研究棟セミナー室
    • Place of Presentation
      東京都文京区
    • Year and Date
      2011-11-19
    • Related Report
      2011 Final Research Report
  • [Presentation] 神経生理機能・人格傾向とゲノム2011

    • Author(s)
      高橋秀俊
    • Organizer
      第二回脳表現型の分子メカニズム研究会チュートリアルコース:ゲノムを用いた脳表現型のトランスレーショナルリサーチ
    • Place of Presentation
      東京大学医学部教育研究棟セミナー室,東京都文京区(招待講演)
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 一般児童・生徒の情緒・行為の問題に対する自閉症的行動特性と気質の影響2011

    • Author(s)
      武井麗子,森脇愛子,高橋秀俊,神尾陽子
    • Organizer
      第52回日本児童青年精神医学会総会
    • Place of Presentation
      あわぎんホール.徳島市
    • Related Report
      2011 Final Research Report
  • [Presentation] 一般児童・生徒の情緒・行為の問題に対する自閉症的行動特性と気質の影響2011

    • Author(s)
      武井麗子, 森脇愛子, 高橋秀俊, ほか
    • Organizer
      第52回日本児童青年精神医学会総会
    • Place of Presentation
      あわぎんホール,徳島県徳島市
    • Related Report
      2011 Annual Research Report
  • [Book] 思春期の子どもの災害反応2011

    • Author(s)
      高橋秀俊,神尾陽子,長尾圭造
    • Publisher
      誠信書房
    • Related Report
      2011 Final Research Report
  • [Book] 思春期の子どもの災害反応.藤森和美,前田正治(編)大災害と子どものストレス2011

    • Author(s)
      高橋秀俊, ほか
    • Publisher
      誠信書房
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.ncnp.go.jp/nimh/jidou/research/research.html

    • Related Report
      2011 Final Research Report

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Published: 2011-09-05   Modified: 2016-04-21  

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