Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2025: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2024: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2023: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Outline of Research at the Start |
We propose to (1) use a drug repurposing approach to redirect A2E aggregates into non-toxic off-pathway oligomers. As a decline in polyamine levels has been implicated in the pathophysiology of aging, we also propose to (2) use spermidine derivatives to act as aldehyde traps for all-trans retinal for limiting the production of A2E. Finally, we propose to (3) limit A2E-induced photodamage by increasing the aggregation of the photoprotective pigment melanin using molecular self-assemblies.
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