Identification of microbiota-dependent serum metabolites associated with immune activation using PD-1 deficient mice model

• Project/Area Number: 23K06603
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49070:Immunology-related
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: TAKAHASHI LUCIA 国立研究開発法人理化学研究所, 生命医科学研究センター, 研究員 (60632982)
• Project Period (FY): 2023-04-01 – 2026-03-31
• Project Status: Granted (Fiscal Year 2023)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2025: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2024: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2023: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: PD-1 / biomarker / immune activation

Outline of Research at the Start

Using PD-1 knockout mouse as model, we aim to identify novel serum metabolites associated with immune activation and evaluate their immune regulatory properties. These compounds can be used as biomarkers for anti-PD-1 tumor therapy, and they can be targeted for the modulation of immune responses.