| Project/Area Number |
23K07800
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 53050:Dermatology-related
|
|---|
| Research Institution | Fukuoka University |
|---|
Principal Investigator |
Loreto Feril 福岡大学, 医学部, 講師 (10435109)
|
|---|
| Project Period (FY) |
2023-04-01 – 2026-03-31
|
| Project Status |
Granted (Fiscal Year 2023)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2025: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2024: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2023: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | Ultrasound / Mechanical effect / Anti cancer effect / Therapeutic Ultrasound |
|---|
| Outline of Research at the Start |
本研究では、低強度超音波(low-intensity ultrasound: LIUS)の全身照射用装置を開発し、悪性黒色腫を標的として、モデルマウスで、その転移・成長抑制効果の確認とその機序解明を目指す。さらにLIUS全身照射と免疫チェックポイント阻害薬(抗PD-1抗体、PD-L1抗体医薬)の併用により相乗的な抗腫瘍効果を発揮させる新規治療の開発を目指す。
|
| Outline of Annual Research Achievements |
Preliminary preparation for animal studies was meticulosly conducted. This involved testing of intraperitoneal injection of cancer cells, diligent of mice, careful design of in-vivo setup for ultrasound exposure, and preparing for the monitoring mechanisms.The safety of low-frequency ultrasound for drug delivery was evaluated in vivo. Specifically, pig skin tissue was irradiated with ultrasonic waves (frequency 47 kHz, sound intensity 1.29 W/cm2, diameter 8 mm, for 10 seconds). No apparent tissue damage occurred in the skin tissue under either continuous ultrasound irradiation for 10 seconds or 10 irradiations of 1 second each. This experiment suggests that low-frequency ultrasound is safe for living organisms.
|
| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
A prototype of the device planned for the first year was created. The safety of low-frequency ultrasound on animal skin was also confirmed. Although actual treatment experiments using tumor models could not be conducted, preparations were made for such experiments. Thus, the research is progressing relatively smoothly.
|
| Strategy for Future Research Activity |
The prototype created this year will be further improved and used for therapeutic experiments on tumor model animals. Furthermore, we will evaluate the improvement of the anti-tumor effect by combining it with antibody drugs.
|
