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SEEG頭蓋内脳波記録によるSUDEPメカニズムの解明

Research Project

Project/Area Number 23K08560
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56010:Neurosurgery-related
Research InstitutionTokyo Medical and Dental University

Principal Investigator

稲次 基希  東京医科歯科大学, 東京医科歯科大学病院, 講師 (00422486)

Project Period (FY) 2023-04-01 – 2027-03-31
Project Status Granted (Fiscal Year 2023)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2026: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2025: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2024: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2023: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsepilepsy / SUDEP / SEEG
Outline of Research at the Start

てんかん患者に対する発作時脳波の広域周波数帯域脳波解析(wideband analysis)の手法を用いて検討し、心電図変化、心拍変動、術前のFDGPET、アデノシン受容体画像などと併せて検討することで、てんかん発作が心臓自律神経系に与える影響を時間的・空間的指標をもって解明し、SUDEPの解明を試みる。

Outline of Annual Research Achievements

①てんかん重積についての臨床結果については、脳神経外科51巻6号に総説を報告した。([Initial Management of Status Epilepticus].Inaji M, Maehara. No Shinkei Geka. 2023 Nov;51(6):1069-1077.)。
②側頭葉てんかんのネットワークについて、側頭葉てんかんにおけるMSTの効果について報告した。(Epilepsy surgery for dominant-side mesial temporal lobe epilepsy without hippocampal sclerosis.Abe D, Inaji M, Hashimoto S, Takagi S, Maehara T.J Clin Neurosci. 2023 May;111:16-21.)。また発作と不安症の関連について報告した(Seizure-related stress and arousal responses mediate a relationship between anxiety trait and state in epilepsy.Nakamura H, Sugihara G, Hara K, Inaji M, Noha M, Takumi I, Watanabe M, Takahashi H, Maehara T, Yamamoto H, Takagi S.Epilepsy Behav. 2023 Oct;147:109442. )さらにはEcoGの技術的な問題について報告したClinical utility and safety of a trapezoid-shaped electrode placement for evaluating the mesio-basal temporal lobe during epilepsy surgery. Kaneko S, Inaji M, Shimizu K, Orihara A, Hashimoto Fujimoto S, Maehara T. J Clin Neurosci. 2024 Mar;121:28-33.)
②AMPA受容体に作用するPER効果について報告した。Long-term efficacy and safety of perampanel as an add-on therapy in patients with epilepsy.Arai Y, Inaji M, Shimizu K, Kondo S, Hashimoto-Fujimoto S, Kiyokawa J, Kawano Y, Yamamoto S, Maehara T.Epilepsy Res. 2024 Feb;200)

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

①発作時前後の心電図変化、つまりてんかん発作の交感神経系への影響については、SEEGを用いた検討でその妥当性を報告(2023年臨床神経生理学会、てんかん学会)した。なお臨床神経生理学会では優秀発表賞を受賞。また発作予知におけるアルゴリズムに関してはAES2023にて報告した。発作と心電図との関連性に関してはおおむね順調です
②特にグルタミン酸受容体のPETに関しては、ITMMを用いて現在結果を解析中。本年度中に論文化が可能な予定である
③PERの臨床効果については、外傷性てんかんおよび重積発作について今年度中の報告が予定されている

Strategy for Future Research Activity

①心拍予定の発作予知は、現在アルゴリズムのさらなる改良を行い、発作予知の前向き研究を予定する。さらにSUDEP症例における特徴を検証する予定である
②multi-tracerを用いたPET検査と、SEEGとの相関に関する研究をさらに進める。特にFDGPETとSEEGでのHFOとの相関を検証予定である

Report

(1 results)
  • 2023 Research-status Report
  • Research Products

    (15 results)

All 2024 2023

All Journal Article (15 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 14 results,  Open Access: 8 results)

  • [Journal Article] Synergistic Interaction of Thyroid Autoantibodies and Ring Finger Protein 213 Variant in Moyamoya Disease2024

    • Author(s)
      THAMAMONGOOD Thiparpa、HARA Shoko、AKAGAWA Hiroyuki、INAJI Motoki、TANAKA Yoji、NARIAI Tadashi、MAEHARA Taketoshi
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 64 Issue: 1 Pages: 43-49

    • DOI

      10.2176/jns-nmc.2023-0169

    • ISSN
      0470-8105, 1349-8029
    • Year and Date
      2024-01-15
    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-term efficacy and safety of perampanel as an add-on therapy in patients with epilepsy2024

    • Author(s)
      Arai Yukika、Inaji Motoki、Shimizu Kazuhide、Kondo Shizukoto、Hashimoto-Fujimoto Satoka、Kiyokawa Juri、Kawano Yoshihisa、Yamamoto Shinji、Maehara Taketoshi
    • Journal Title

      Epilepsy Research

      Volume: 200 Pages: 107307-107307

    • DOI

      10.1016/j.eplepsyres.2024.107307

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decreased diffusivity along the perivascular space and cerebral hemodynamic disturbance in adult moyamoya disease2024

    • Author(s)
      Hara Shoko、Kikuta Junko、Takabayashi Kaito、Kamagata Koji、Hayashi Shihori、Inaji Motoki、Tanaka Yoji、Hori Masaaki、Ishii Kenji、Nariai Tadashi、Taoka Toshiaki、Naganawa Shinji、Aoki Shigeki、Maehara Taketoshi
    • Journal Title

      Journal of Cerebral Blood Flow & Metabolism

      Volume: online ahead of print Issue: 10 Pages: 1-14

    • DOI

      10.1177/0271678x241245492

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loss of methylthioadenosine phosphorylase immunoreactivity correlates with poor prognosis and elevated uptake of 11C-methionine in IDH-mutant astrocytoma2024

    • Author(s)
      Yamamura Toshihiro、Tamura Kaoru、Kobayashi Daisuke、Inaji Motoki、Toyama Yuka、Wakimoto Hiroaki、Kiyokawa Juri、Hara Shoko、Tanaka Yoji、Nariai Tadashi、Shimizu Kazuhide、Ishii Kenji、Maehara Taketoshi
    • Journal Title

      Journal of Neuro-Oncology

      Volume: - Issue: 2 Pages: 355-365

    • DOI

      10.1007/s11060-024-04661-y

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical utility and safety of a trapezoid-shaped electrode placement for evaluating the mesio-basal temporal lobe during epilepsy surgery2024

    • Author(s)
      Kaneko Satoshi、Inaji Motoki、Shimizu Kazuhide、Orihara Asumi、Hashimoto Fujimoto Satoka、Maehara Taketoshi
    • Journal Title

      Journal of Clinical Neuroscience

      Volume: 121 Pages: 28-33

    • DOI

      10.1016/j.jocn.2024.01.026

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of [11C]methionine PET with Bayesian penalized likelihood reconstruction on glioma grades based on new WHO 2021 classification2024

    • Author(s)
      Wagatsuma Kei、Ikemoto Kensuke、Inaji Motoki、Kamitaka Yuto、Hara Shoko、Tamura Kaoru、Miwa Kenta、Tsuzura Kaede、Tsuruki Taisei、Miyaji Noriaki、Ishibashi Kenji、Ishii Kenji
    • Journal Title

      Annals of Nuclear Medicine

      Volume: 38 Issue: 5 Pages: 400-407

    • DOI

      10.1007/s12149-024-01911-x

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The current status of reversal therapy in Japan for elderly patients with head injury treated with antithrombotic agents: a prospective multicenter observational study.2024

    • Author(s)
      Suehiro E, Shiomi N, Yatsushige H, Hirota S, Hasegawa S, Karibe H, Miyata A, Kawakita K, Haji K, Aihara H, Yokobori S, Inaji M, Maeda T, Onuki T, Oshio K, Komoribayashi N, Suzuki M.
    • Journal Title

      Heliyon

      Volume: 10 Issue: 3 Pages: e25193-e25193

    • DOI

      10.1016/j.heliyon.2024.e25193

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intracranial residual lesions following early intensification in a patient with T-cell acute lymphoblastic leukemia: a case report2024

    • Author(s)
      Nagamatsu Yuichi、Isoda Takeshi、Inaji Motoki、Oyama Jun、Niizato Daiki、Tomomasa Dan、Mitsuiki Noriko、Yamashita Motoi、Kamiya Takahiro、Imai Kohsuke、Kanegane Hirokazu、Morio Tomohiro、Takagi Masatoshi
    • Journal Title

      BMC Pediatrics

      Volume: 24 Issue: 1

    • DOI

      10.1186/s12887-024-04790-3

    • Related Report
      2023 Research-status Report
  • [Journal Article] Stroke and disease progression during long-term follow-up of patients with moyamoya disease older than 50 years2024

    • Author(s)
      Sakai Ryosuke、Hara Shoko、Inaji Motoki、Tanaka Yoji、Nariai Tadashi、Maehara Taketoshi
    • Journal Title

      World Neurosurgery

      Volume: 187 Pages: e898-e907

    • DOI

      10.1016/j.wneu.2024.05.008

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Spontaneous occlusion of ruptured microaneurysm formed on postoperative transosseous anastomosis after indirect revascularization in a patient with moyamoya disease2024

    • Author(s)
      Kondo Kazuki、Hara Shoko、Kaneoka Azumi、Inaji Motoki、Tanaka Yoji、Nariai Tadashi、Maehara Taketoshi
    • Journal Title

      Acta Neurochirurgica

      Volume: 166 Issue: 1

    • DOI

      10.1007/s00701-024-06102-1

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] 特集 神経救急-初期診療から集中治療までエキスパートの暗黙知に迫る Ⅲ 疾患別の初期診療 てんかん重積状態の初期診療2023

    • Author(s)
      稲次 基希、前原 健寿
    • Journal Title

      Neurological Surgery 脳神経外科

      Volume: 51 Issue: 6 Pages: 1069-1077

    • DOI

      10.11477/mf.1436204853

    • ISSN
      0301-2603, 1882-1251
    • Year and Date
      2023-11-10
    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Epilepsy surgery for dominant-side mesial temporal lobe epilepsy without hippocampal sclerosis2023

    • Author(s)
      Abe Daisu、Inaji Motoki、Hashimoto Satoka、Takagi Shunsuke、Maehara Taketoshi
    • Journal Title

      Journal of Clinical Neuroscience

      Volume: 111 Pages: 16-21

    • DOI

      10.1016/j.jocn.2023.02.017

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nonconvulsive status epilepticus characteristics in glioma patients: a retrospective study2023

    • Author(s)
      Kaneoka A, Fujimoto SH, Tamura K, Inaji M, Maehara T.
    • Journal Title

      Discov Oncol

      Volume: Mar 7;14(1):30 Issue: 1 Pages: 30-30

    • DOI

      10.1007/s12672-023-00632-3

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Seizure-related stress and arousal responses mediate a relationship between anxiety trait and state in epilepsy2023

    • Author(s)
      Hironobu Nakamura a b, Genichi Sugihara a, Keiko Hara b c, Motoki Inaji d, Masahiro Noha e, Ichiro Takumi f, Masako Watanabe g, Hidehiko Takahashi a h, Taketoshi Maehara d, Hitoshi Yamamoto i, Shunsuke Takagi
    • Journal Title

      Epilepsy & Behavior

      Volume: 147 Pages: 109442-109442

    • DOI

      10.1016/j.yebeh.2023.109442

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] ATP1A3-related early childhood onset developmental and epileptic encephalopathy responding to corpus callosotomy: A case report2023

    • Author(s)
      Moriyama Kengo、Mizuno Tomoko、Suzuki Tomonori、Inaji Motoki、Maehara Taketoshi、Fujita Atsushi、Kato Mitsuhiro、Matsumoto Naomichi
    • Journal Title

      Brain and Development

      Volume: 45 Issue: 1 Pages: 77-81

    • DOI

      10.1016/j.braindev.2022.08.009

    • Related Report
      2023 Research-status Report
    • Peer Reviewed

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Published: 2023-04-13   Modified: 2024-12-25  

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