|Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2025: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2024: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|Outline of Research at the Start
Achieving complete and functional dental pulp tissue regeneration remains a challenge. Data shows that autophagy improves dental pulp regeneration by enhancing vascularization. The protein complex, NLRP3 inflammasome, inhibits autophagy, therefore, their role in dental regeneration needs clarification. Thus, we aim to study if NLRP3 inflammasome inhibition promotes odontoblast formation in an extra-oral tooth transplantation model. Using NLRP3-specific inhibitors and histological analysis of dental pulp, the role of NLRP3-autophagy interplay in dental pulp regeneration will be elucidated.