Potential role of chemokine (C-C motif) ligand 18 in the development of obese asthma and Type 2 inflammation using epidemiological and experimental studies

• Project/Area Number: 23K09664
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 58020:Hygiene and public health-related: including laboratory approach
• Research Institution: Hokkaido University
• Principal Investigator: Goudarzi Houman 北海道大学, 医学研究院, 准教授 (40713607)
• Project Period (FY): 2023-04-01 – 2026-03-31
• Project Status: Granted (Fiscal Year 2023)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2025: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2024: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2023: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: Obese asthma phenotype / CCL18 / Cohort studies / T2 inflammation / Experimental studies

Outline of Research at the Start

For the first time, we will show the effects of human CCL18 in the development of obese asthma and enhancement of Th2 inflammation in the general population of children and adult asthmatic patients. Additionally, a detailed mechanism of CCL18 regulation and the role of CCL18 in eosinophilic airway inflammation in obese asthma phenotypes will be addressed for the first time in experimental studies. This project is a collaboration between clinicians and epidemiologists, providing this opportunity to improve children's health by translating the findings from bench to bedside.