Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2025: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2024: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2023: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Outline of Research at the Start |
Nicotine and ethanol (EtOH) are often consumed together and produce an additive increase in dopamine release in the nucleus accumbens. COA-Cl has recently been shown to increase dopamine levels and to exert neuroprotective effects both in vivo and in vitro. Thus, the present study is aimed to investigate whether a combination of COA-Cl, EtOH and/or nicotine exerts additive neuroprotective effects against MPTP-induced neurotoxicity, and to identify its underlying mechanisms, with a focus on apoptosis.
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