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Multi-Resolution Curriculum Learning Guided Convolutional Neural Networks for Automatic Segmentation of iPS Cell Colonies

Research Project

Project/Area Number 23K11170
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 61010:Perceptual information processing-related
Research InstitutionHiroshima University

Principal Investigator

RAYTCHEV BISSER・ROUMENOV  広島大学, 先進理工系科学研究科(工), 准教授 (00531922)

Project Period (FY) 2023-04-01 – 2026-03-31
Project Status Granted (Fiscal Year 2023)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2025: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2024: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2023: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsdeep learning / automatic image analysis / uncertainty / neural networks / image analysis / reliable AI
Outline of Research at the Start

In this research project novel deep learning based machine learning methods will be investigated for automatic bio-medical image analysis, which can work reliably in critical settings where safety is first priority.

Outline of Annual Research Achievements

In recent years deep neural networks have achieved SOTA(state-of-the-art) performance on many automatic image analysis tasks, even surpassing human-level performance in certain cases. However, they still perform less than satisfactory when test data differs significantly from the data with which they have been trained with (and especially in cases where the training data sets are small). This is particularly important in bio-medical images, where over-confidence in the predictions can lead to life-threatening situations and in images obtained when studying physics-related phenomena, which differ significantly from the natural images used to train the current SOTA deep learning methods.

During the 1st year of the project we have experimented with using Bayesian neural networks to quantify the uncertainty and a baby-step curriculums learning method which mimics how people learn starting from easy data and gradually moving to difficult one. In order to obtain a more objective evaluation of the efficacy of the proposed methods we have decided to use more difficult data: e.g. skin lesions data which is widely used for many medical challenge competitions for medical images, and images of bag-breakup-related fluid phenomena for more general scientific images. In the latter case, we developed a novel algorithm which utilizes information from several consecutive frames and significantly improves accuracy of detection (even compared with present SOTA algorithms) by eliminating false positives which are difficult to discriminate from a single image even for human experts.

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

The initial plan was to investigate novel machine learning methods (like for example curriculum learning based methods for quantifying and reducing the uncertainty in the automatic analysis of bio-medical images (one concrete example being images of iPS cell colonies, with which we had done some pioneer work before) in order to contribute to the design of more reliable automatic image analysis systems which can work reliably in the presence of uncertainty, especially in cases where it is difficult to obtain a huge number of training images. Obtained experimental results during the first year of the project have shown that better results can be obtained by not limiting our attention to curriculum learning, but for example combining it with novel data augmentation methods (for bio-medical images), or using temporal information from several consecutive frames (in the case of general images of physical phenomena like bag-breakups).

Strategy for Future Research Activity

During the next stage of the project we plan to continue the development of novel deep learning methods for improving the accuracy and reducing the uncertainty in the automatic analysis of both general and bio-medical images, thus endeavoring to contribute to the development of more reliable and trustworthy AI-based systems. We plan to continue our effort for developing a curriculum learning method combined with novel data augmentation methods in the context of bio-medical images and additionally to experiment with some other types of data where uncertainty can lead to life-threatening situations, like for example with data obtained from the cameras of self-driving vehicles.

Report

(1 results)
  • 2023 Research-status Report
  • Research Products

    (10 results)

All 2024 2023 Other

All Int'l Joint Research (1 results) Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Int'l Joint Research] University of Pisa(イタリア)

    • Related Report
      2023 Research-status Report
  • [Journal Article] Fast detection of bag-breakups in pulsating and steady airflow using video analysis and deep learning2023

    • Author(s)
      Morita Daiki、Raytchev Bisser、Elhanashi Abdussalam、Kawaguchi Mikimasa、Ogata Yoichi、Higaki Toru、Kaneda Kazufumi、Nakashima Akira、Saponara Sergio
    • Journal Title

      Journal of Real-Time Image Processing

      Volume: 20 Issue: 6

    • DOI

      10.1007/s11554-023-01363-y

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An integrated and real-time social distancing, mask detection, and facial temperature video measurement system for pandemic monitoring2023

    • Author(s)
      Elhanashi Abdussalam、Saponara Sergio、Dini Pierpaolo、Zheng Qinghe、Morita Daiki、Raytchev Bisser
    • Journal Title

      Journal of Real-Time Image Processing

      Volume: 20 Issue: 5

    • DOI

      10.1007/s11554-023-01353-0

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Spectral Super-Resolution for High Dynamic Range Images2023

    • Author(s)
      Mikamoto Yuki、Kaminaka Yoshiki、Higaki Toru、Raytchev Bisser、Kaneda Kazufumi
    • Journal Title

      Journal of Imaging

      Volume: 9 Issue: 4 Pages: 83-83

    • DOI

      10.3390/jimaging9040083

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 表面粗さを考慮した薄膜干渉のスペクトラルレンダリング2023

    • Author(s)
      上中喜生, 檜垣徹, Bisser Raytchev, 金田和文
    • Journal Title

      画像電子学会誌

      Volume: 52-4 Pages: 507-515

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Presentation] Real-Time Intuitive Interaction and Realistic Illumination for CT Volume Rendering2024

    • Author(s)
      Kousuke Katayama, Toru Higaki, Kazufumi Kaneda, Bisser Raytchev, Wataru Fukumoto
    • Organizer
      The 8th IIEEJ International Conference on Image Electronics and Visual Computing (IEVC 2024). National Cheng Kung University, Tainan City, Taiwan.
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Efficient and Accurate Physically Based Rendering of Periodic Multilayer Structures with Iridescence2023

    • Author(s)
      Yoshiki Kaminaka, Toru Higaki, Bisser Raytchev, Kazufumi Kaneda
    • Organizer
      Proc. SIGGRAPH Asia 2023 Posters
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] 流体シミュレーションにおける深層学習モデル適用の検討2023

    • Author(s)
      黒川幸将,山脇香菜,Bisser Raytchev,野村典文,尾形陽一,川口幹祐,上村匠,檜垣徹,金田和文
    • Organizer
      第26回 画像の認識・理解シンポジウム (MIRU2023)
    • Related Report
      2023 Research-status Report
  • [Presentation] Transformerを用いたマルチタスク学習による流体解析の時間効率改善に関する研究2023

    • Author(s)
      笹口翔,Bisser Raytchev,川口幹祐,植木義治,小林謙太,和田好隆,上村匠,佐藤圭峰,檜垣徹,金田和文
    • Organizer
      第26回 画像の認識・理解シンポジウム (MIRU2023)
    • Related Report
      2023 Research-status Report
  • [Presentation] 機械学習を用いた冷媒回路のサロゲートモデル化に関する研究2023

    • Author(s)
      中直斗,Bisser Raytchev,笹口翔伍,上村匠,川口幹祐,佐藤圭峰,植木義治,小林謙太,和田好隆,檜垣徹,金田和文
    • Organizer
      第26回 画像の認識・理解シンポジウム (MIRU2023)
    • Related Report
      2023 Research-status Report

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Published: 2023-04-13   Modified: 2024-12-25  

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