Construction of 3D hierarchical vascular networks in a cm-sized liver tissue using magnetic fields

• Project/Area Number: 23K13291
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 20020:Robotics and intelligent system-related
• Research Institution: Nagoya University
• Principal Investigator: 金 恩恵 名古屋大学, 未来社会創造機構, 研究員 (30972517)
• Project Period (FY): 2023-04-01 – 2026-03-31
• Project Status: Granted (Fiscal Year 2023)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2025: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2024: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2023: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: Micromanipulation / Magnetic field / 3D cellular structure / 3D vascular network / tissue engineering

Outline of Research at the Start

I will construct 3D hierarchical vascular networks in centimeter-sized live tissues in vitro using magnetic fields. The target size is a liver having 13cm of diameter and hierarchical vessels from portal vein to hepatic sinusoids.