| Project/Area Number |
23K13760
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 34010:Inorganic/coordination chemistry-related
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
CATTI LORENZO 東京工業大学, 科学技術創成研究院, 助教 (50873478)
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| Project Period (FY) |
2023-04-01 – 2026-03-31
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| Project Status |
Granted (Fiscal Year 2023)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2025: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2024: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2023: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | functionalized capsule / functionalized ligand / heterocapsule / テルペン環化反応 |
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| Outline of Research at the Start |
Preparation of novel ligands with covalently attached acid functionalities.
Formation of nanosized M2L4 coordination capsules via self-assembly of these ligands in the presence of metal ions (Pd2+ or Pt2+).
Cyclization of linear terpene substrates inside the obtained capsules via protonation in water.
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| Outline of Annual Research Achievements |
The synthesis of a new bent endo-functionalized bispyridine ligand was achieved. During the synthesis the convex-selective deprotection of the alkoxy groups was successfully performed. The ligand features an internal OAc or OH substituent. Combination of this ligand with metal ions resulted in the formation of an internally functionalized coordination capsule, as indicated by NMR analysis. The formed capsule is believed to contain both internal OH and OAc functionalities, since a mixture of the functionalized ligand was used. Formation of such heterocapsules is an important step toward mimicking the active centers of natural enzymes.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
The synthesis of the ligand was achieved without major problems. Importantly, the obtained OH functionalized ligand can likely be converted into other functionalized ligands, e.g. ones containing acidic groups. Additionally, current NMR data indicates formation of otherwise difficult-to-obtain heterocapsules, which might prove valuable for the selective recognition of biomolecules in water.
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| Strategy for Future Research Activity |
First the purification of the obtained ligand will be finalized, since the current ligand is obtained as a mixture of OH- and OAc-functionalized ligands. With the separated ligands in hand, we will first study the formation of homocapsules and their selective guest-uptake abilities. Next we will study the selective formation of e.g. 2+2 heterocapsules using a mixture of functionalized and unfunctionalized ligands. Selective formation will be attempted using template guest molecules or using functionalized ligands with sterically bulky substituents.
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