Identification of potential therapeutic lead compounds targeting serine-palmitoyltransferase

• Project/Area Number: 23K13858
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 37030:Chemical biology-related
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Pham LienThiKim 国立研究開発法人理化学研究所, 環境資源科学研究センター, 特別研究員 (50865300)
• Project Period (FY): 2023-04-01 – 2026-03-31
• Project Status: Granted (Fiscal Year 2023)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2025: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2024: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2023: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: SPT inhibitors / potent compounds / chemical-genomics

Outline of Research at the Start

A direct inhibitor of Serine-palmitoyltransferase (SPT) will hold promise for future therapeutic studies. In this study, based on the yeast chemical-genomics screening data from thousands of bioactive compounds from the RIKEN Natural Product Depository and the University of Tokyo Drug Discovery Initiative Core Libraries, we focus on identifying new potent compounds that target SPT selectively.