| Project/Area Number |
23K14062
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 42010:Animal production science-related
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| Research Institution | Tohoku University |
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Principal Investigator |
イスラム ジャヒドゥル 東北大学, 農学研究科, 特任助教 (20805569)
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| Project Period (FY) |
2023-04-01 – 2025-03-31
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| Project Status |
Granted (Fiscal Year 2023)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2024: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2023: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Single Cell / Plasma cell / IgA |
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| Outline of Research at the Start |
During lactation period, plasma cells (PCs) are transferred from small intestine to mammary gland and actively joined to humoral immunity, however their phenotype, function, and localization are seemed to differ. This study aims to visualize the full spectrum of PCs phenotypes, functionality, and characteristics in mouse small intestine lamina propria and mammary gland during lactation period by performing single-cell RNA-seq (scRNA-seq). The results obtained from single cells analysis may help to adopt novel strategy for mucosal vaccine design as well as boosting the maternal immunity.
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