Elucidating Semaphorin-6D Signaling Axis in Huntington's Disease

• Project/Area Number: 23K14503
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 49030:Experimental pathology-related
• Research Institution: Osaka University
• Principal Investigator: ファトバ オルワシン 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) (90870296)
• Project Period (FY): 2023-04-01 – 2026-03-31
• Project Status: Granted (Fiscal Year 2023)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2025: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2024: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2023: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: Huntington’s disease / SEMA6D / PlexinA1 / Neurodegeneration / Neuroinflammation

Outline of Research at the Start

SEMA6D exhibit diverse functional relevance in the central nervous systems. However, the role of SEMA6D in the pathomechanism of neurodegenerative diseases is unknown. Herein, we aim to elucidate the pathophysiological roles, mechanism of action, and therapeutic benefits of SEMA6D in HD pathology.