Identification and characterization of a ligand for the inhibitory immunoreceptor Allergin-1 on mast cells

Research Project

Project/Area Number	23K14537
Research Category	Grant-in-Aid for Early-Career Scientists
Allocation Type	Multi-year Fund
Review Section	Basic Section 49070:Immunology-related
Research Institution	University of Tsukuba
Principal Investigator	SilvaAlmeida Mariana 筑波大学, 革新的創薬開発研究センター, 研究員 (70971589)
Project Period (FY)	2023-04-01 – 2025-03-31
Project Status	Granted (Fiscal Year 2023)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2024: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2023: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	Type I hypersensitivity / Mast cells / ITIM / Allergin-1 / IgE
Outline of Research at the Start	Allergin-1 is an inhibitory immunoreceptor and inhibits IgE-FcεRI-mediated signaling in mast cells to suppress type 1 allergic reactions. This study identified a candidate molecule for Allergin-1 ligand, and aims to clarify this molecule's role as a functional ligand.