The potential role and mechanism of mitophagy in maintaining the biological characteristics of cancer stem cells

• Project/Area Number: 23K14598
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 50010:Tumor biology-related
• Research Institution: Nagasaki University
• Principal Investigator: YAN Chen 長崎大学, 原爆後障害医療研究所, 講師 (70968396)
• Project Period (FY): 2023-04-01 – 2025-03-31
• Project Status: Granted (Fiscal Year 2023)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2024: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2023: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: Cancer stem cells / Mitophagy / Cancer

Outline of Research at the Start

Cancer stem cells (CSCs) are known to associate with therapeutic resistance and cancer relapse. We will investigate the role and mechanism of mitophagy in maintaining the biological characteristics of CSCs. Our study will provide new insight into mechanism on the biological characteristics of CSCs.