| Project/Area Number |
23K14668
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 50020:Tumor diagnostics and therapeutics-related
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| Research Institution | National Center for Child Health and Development |
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Principal Investigator |
Hu Xin 国立研究開発法人国立成育医療研究センター, 移植免疫研究室, (非)研究員 (40868965)
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| Project Period (FY) |
2023-04-01 – 2025-03-31
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| Project Status |
Granted (Fiscal Year 2023)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2024: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2023: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Combined phospholipids / TADC / TIL / TME / cancer immunotherapy / combined phospholipids / TADCs / TILs / tumor microenvironment |
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| Outline of Research at the Start |
Targeting TADCs may provide effective immunotherapy for cancer.PS can enhance the recognition, processing and antigen presentation of DC. We will focus on how to improve the efficacy of the TADCs anti-tumor therapy with the phospholipids treatment and their synergistic effects mechanism.
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| Outline of Annual Research Achievements |
1,Administering phospholipids significantly inhibited tumor growth in B6 mice with established subcutaneous B16F10 tumors and in BalB/c mice with established subcutaneous C26 tumors. 2,Our research revealed that phospholipids markedly boost the expression of CD86 and MHCII,and the cytokine secretion . 3,TADCs expression Tim-4
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
1, We cirform the anti-tumor effect of Phospholipids in different tumor model.
2, We cirform the phospholipids enhance TADCs anti-tumor effect in vivo and in vitro
3, We cirform the mechanism for phospholipids promoting TADCs anti-tumor effect
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| Strategy for Future Research Activity |
Next, we will use the exploration of mechanisms as our research.
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