Comprehensive understanding of the behavioral and pathophysiological mechanisms in autism spectrum disorder (ASD) using CRISPR/Cas9-induced fmr1 and ube3a mutant zebrafish.

• Project/Area Number: 23K14672
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 51010:Basic brain sciences-related
• Research Institution: Niigata University
• Principal Investigator: DOUGNON Godfried 新潟大学, 脳研究所, 助教 (20964985)
• Project Period (FY): 2023-04-01 – 2026-03-31
• Project Status: Granted (Fiscal Year 2023)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2025: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2024: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2023: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: Autism / Zebrafish / Neurodevelopmental / Behavior / Loss-of-function

Outline of Research at the Start

FMR1 and UBE3A are two different genes linked to autism. We will use the zebrafish, very similar to human in behavior and genetics, to study their distinct pathology and behaviors related to autism. The results could help scientists to better understand their common pathways and autism mechanisms.