Interplay between mitophagy and pathogens in neuroinflammation

• Project/Area Number: 23K14675
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 51010:Basic brain sciences-related
• Research Institution: Juntendo University
• Principal Investigator: COSSU DAVIDE 順天堂大学, 健康総合科学先端研究機構, 准教授 (90867326)
• Project Period (FY): 2023-04-01 – 2026-03-31
• Project Status: Granted (Fiscal Year 2023)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2025: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2024: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2023: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: mitophagy / infection / neuroinflammation / EAE

Outline of Research at the Start

To investigate the relationships between mitophagy, infections and neuroinflammation, the project is divided into different phases: 1) microbial identification in patients, 2) gene expression analysis in patients, 3) development of animal models to study the effect of mitophagy and infections.