Development of non-invasive measurement and induction of multivariate sharp-wave ripples in the human brain

Research Project

Project/Area Number	23K14679
Research Category	Grant-in-Aid for Early-Career Scientists
Allocation Type	Multi-year Fund
Review Section	Basic Section 51020:Cognitive and brain science-related
Research Institution	The University of Tokyo
Principal Investigator	大城武史東京大学, ニューロインテリジェンス国際研究機構, 特任研究員 (70807875)
Project Period (FY)	2023-04-01 – 2026-03-31
Project Status	Granted (Fiscal Year 2023)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2025: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000) Fiscal Year 2024: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2023: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords	sharp-wave ripples / リップル波誘導 / MEG / 加齢 / 学習
Outline of Research at the Start	①脳の興奮性及び抑制性シグナルバランスを直接的に反映するリップル波に着目した加齢プロセスの解明 ②適切な興奮性抑制性シグナルバランスを非侵襲的に誘導するデジタルディバイス（ripple　entrainment using sensory stimuli[RENUS]）の開発 ③RENUSを用いた認知症の病態改善及び学習効果の延伸の検証