The development of MRI-based non-invasive biomarkers to investigate the effect of vascular risk factors on the glymphatic system
| Project/Area Number |
23K14927
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Juntendo University |
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Principal Investigator |
アンディカ クリスティーナ 順天堂大学, 健康データサイエンス学部, 講師 (00965460)
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| Project Period (FY) |
2023-04-01 – 2026-03-31
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| Project Status |
Granted (Fiscal Year 2023)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2025: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2024: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2023: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | Glymphatic system / Metabolic sydrome / Marijuana / DTI-ALPS / Free water imaging / Metabolic syndrome / Cognitive decline / Motor impairment / MRI |
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| Outline of Research at the Start |
Metabolic syndrome (MetS) has recently been linked to reduced removal of brain waste products, leading to cognitive decline and motor impairment. Our study aims to: (A) develop and validate noninvasive MRI-based biomarkers for elucidating the effect of MetS or its components on glymphatic system compartments; (B) predict subjects with MetS or its components at risk of developing glymphatic dysfunction-related cognitive decline and motor impairment; and (C) clarify vascular and modifiable lifestyle risk factors of glymphatic dysfunction for integrating preventive and therapeutic strategies.
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| Outline of Annual Research Achievements |
In the present research project, diffusion magnetic resonance imaging-based measures were applied to evaluate the glymphatic system function. The glymphatic system is a glial-based perivascular network that promotes brain metabolic waste clearance.
Our findings were as follows:
1. Glymphatic system alterations in older adults with metabolic sydrome: we showed reduced glymphatic clearance function in older adults with metabolic syndrome, possibly due to the adverse effects of vascular risk factors on the glymphatic system. Our findings also indicate associations between reduced glymphatic clearance function and elevated diastolic blood pressure, hyperglycemia, smoking habit, and poorer cognitive performance.
2. Glymphatic system alterations in marijuana users: we observed the adverse effects of younger age at first use of marijuana on glymphatic system function, which is associated with impaired working memory and fluid intelligence.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
As planned, data can be collected in a timely manner, and data analysis and paper writing can also proceed according to schedule.
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| Strategy for Future Research Activity |
Data analysis is currently underway to evaluate the relationship between impaired glymphatic system function and changes in brain microstructure.
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Report
(1 results)
Research Products
(2 results)
