| Project/Area Number |
23K15292
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | Juntendo University |
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Principal Investigator |
趙 巧鳳 順天堂大学, 大学院医学研究科, 博士研究員 (60934601)
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| Project Period (FY) |
2023-04-01 – 2026-03-31
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| Project Status |
Granted (Fiscal Year 2023)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2025: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2024: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2023: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Stress / Atopic dermatitis |
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| Outline of Research at the Start |
Atopic dermatitis (AD), which is a chronic inflammatory skin disease, manifests as intractable itch. Psychological stress may have a role in the onset or exacerbation of skin disorders such as AD. However, pathophysiologic links between psychological stressors and cutaneous manifestations remain unclear. Therefore, this study focuses on the hypothalamic-pituitary-adrenal axis (HPA) and aims to elucidate the mechanism of exacerbation of the pathogenesis of atopic dermatitis, including itching and dermatitis, and delayed recovery by applying psychological stress to a mouse model of AD.
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| Outline of Annual Research Achievements |
Atopic dermatitis (AD), which is a chronic inflammatory skin disease, manifests as intractable itch. Psychological stress may have a role in the onset or exacerbation of skin disorders such as AD. Psychological stress may influence AD, but the links between psychological stressors and cutaneous manifestations remain unclear.
I have completed the essential techniques for studying Project 1, which include the following steps:
1. Inducing AD-like symptoms; 2. Selecting stressors: Three different types of stressors are selected for stress loading, including WS, RS, and R-SDS; 3. Evaluating the effects of stress on AD symptoms; 4. Studying the effects of stress on alloknesis.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
The following research project 1(Generation of AD-like model and evaluation of psychological stress load) was completed last year.
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| Strategy for Future Research Activity |
The following research Project 2:Effects of psychological stress on the structure and function of skin barrier and sensory nerve fibers:
1, [Effects of stress on AD symptoms] The selected stresses will be given from the AD-induced process to NC/Nga mice to evaluate the skin barrier itch behavior and the degree of dermatitis to study the effect of stress on AD pathogenesis.
2, [Effects of stress on sensory nerve fibers] To further confirm the skin barrier disruption and sensory nerve fibers, I will collect and analyze the skin tissues from each group for immunohistochemical and histology.
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