Effects of psychological stressors on the pathogenesis of atopic dermatitis

• Project/Area Number: 23K15292
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: Juntendo University
• Principal Investigator: 趙 巧鳳 順天堂大学, 大学院医学研究科, 博士研究員 (60934601)
• Project Period (FY): 2023-04-01 – 2026-03-31
• Project Status: Granted (Fiscal Year 2023)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2025: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2024: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2023: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: Stress / Atopic dermatitis

Outline of Research at the Start

Atopic dermatitis (AD), which is a chronic inflammatory skin disease, manifests as intractable itch. Psychological stress may have a role in the onset or exacerbation of skin disorders such as AD. However, pathophysiologic links between psychological stressors and cutaneous manifestations remain unclear. Therefore, this study focuses on the hypothalamic-pituitary-adrenal axis (HPA) and aims to elucidate the mechanism of exacerbation of the pathogenesis of atopic dermatitis, including itching and dermatitis, and delayed recovery by applying psychological stress to a mouse model of AD.