| Project/Area Number |
23K16301
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 58020:Hygiene and public health-related: including laboratory approach
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Wai KyiMar 東京大学, 大学院医学系研究科(医学部), 助教 (10867154)
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| Project Period (FY) |
2023-04-01 – 2025-03-31
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| Project Status |
Granted (Fiscal Year 2023)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2024: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2023: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | Telomere / Positive Deviance / Ageing |
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| Outline of Research at the Start |
Telomere length (TL) has been proposed as a biomarker of biological aging. Positive deviance (PD) concept is idealized for improving public health locally, as the whole community can adopt a healthy lifestyle from healthy peers. It is not possible to clone people; however, it could be possible to understand the unique PD characteristics and have close care on those for socio-behavioral modifications. This study will firstly identify PD characteristics that cope well with premature biological aging, and it would be beneficial to design tailor-made interventions that are applicable in community.
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| Outline of Annual Research Achievements |
Telomere length (TL) has been proposed as a biomarker of biological aging. Assuming positive deviants as individuals with a longer TL compared to their peers, I am conducting a community-based cross-sectional study to identify PD characteristics that have the potential to prevent biological aging using the data/biological samples of approximately 1000 participants from the Iwaki health promotion project. The data usage application and the ethical procedure were performed in 2023FY. The questionnaire data and biological sample data were acquired. We will additionally measure the biochemical variables in the urine samples. The protocols and experiment conditions were tested, and trial measurements were performed. The preliminary data analysis of descriptive data was performed.
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| Current Status of Research Progress |
Current Status of Research Progress
3: Progress in research has been slightly delayed.
Reason
There was an unexpected delay in the measurements of variables in urine samples. Due to the change of the affiliation and work location of the principal researcher in the middle of the project, the ethical procedure and material transfer of the samples were performed accordingly to process the data analysis and sample measurements. Thus, the research is slightly behind schedule.
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| Strategy for Future Research Activity |
I plan to perform urine samples analytical measurements, data analysis, and interpretation of results.
I will present the research findings at domestic and international conferences. Moreover, I will prepare the manuscript and publish it in an international peer-reviewed journal.
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