The regulatory roles of ACE2 and its interaction with Nrf2 in arsenic-induced endothelial dysfunction in experimental and epidemiological studies

• Project/Area Number: 23K16310
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 58020:Hygiene and public health-related: including laboratory approach
• Research Institution: Jichi Medical University
• Principal Investigator: ラハマン エムディー・シブルール 自治医科大学, 医学部, 客員研究員 (90897901)
• Project Period (FY): 2023-04-01 – 2026-03-31
• Project Status: Granted (Fiscal Year 2023)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2025: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2024: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2023: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: Arsenic / Endothelial dysfunction / HUVECs / Hypertension

Outline of Research at the Start

Now, it is evident that low concentration and chronic arsenic exposure induced hypertension and cardiovascular diseases. In preliminary cell culture experiments, we observed that arsenic-induced endothelial dysfunction was associated with the renin-angiotensin system. Arsenic also induces endothelial dysfunction by generating excessive reactive oxygen species and by disrupting the antioxidant defense in the biological system. The proposed study aims to clarify the regulatory role of ACE2 and its interaction with Nrf2 in arsenic-induced endothelial dysfunction using experimental studies.