| Project/Area Number |
23K17239
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 90130:Medical systems-related
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| Research Institution | National Institutes for Quantum Science and Technology |
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Principal Investigator |
KANG HANGYU 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所 先進核医学基盤研究部, 主任研究員 (90824467)
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| Project Period (FY) |
2023-04-01 – 2025-03-31
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| Project Status |
Granted (Fiscal Year 2023)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2024: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2023: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | Small animal PET / In vivo imaging / High-resolution / 小動物PET / 超高分解能 / 分子イメージング |
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| Outline of Research at the Start |
市販小動物PET装置の分解能は1.2～1.6 mmであるため、1 mm未満のサイズであるマウスの脳の皮質や視床を識別は困難である。マウスの脳の神経活動を正確に可視化するためには1 mm未満の分解能が要求されたいる。本研究では、オフセット式で積層された3層の放射線検出器を用いて0.4 mmの超高分解能小動物PETを開発する。本研究の超高分解能小動物PETは脳疾患モデルのマウスで新しいバイオマーカーの発見に役立つと期待している。
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| Outline of Annual Research Achievements |
<Optimization of the crystal and PET geometries>
A Monte Carlo simulation study was performed to find out the optimal crystal geometry in terms of spatial resolution. The optimal crystal geometry has 3-layer staggered depth-of-interaction (DOI) configuration, in which the 1st, 2nd, and 3rd layers have 3 mm, 3 mm, and 5 mm thereby resulting the total thickness of 11 mm. The crystal pitch of 0.8 mm and reflector thickness of 0.1 mm were selected. The optimized PET geometry has an inner diameter of 48 mm, and axial coverage of 23.4 mm.
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| Current Status of Research Progress |
Current Status of Research Progress
1: Research has progressed more than it was originally planned.
Reason
<PET geometry optimization>
The crystal and PET geometries were optimized by using the Monte Carlo simulation software in time.The Monte Carlo simulation results were submitted to an international conference, which will be held in the US in 2024.
<Front-end electronics design>
In addition, the signal processing electronics such as front-end boards and amplifier boards were designed, which were originally scheduled on the second fiscal year. The front-end readout boards and amplifier boards were designed by using Altium Designer software. The developed front-end and amplifier boards were working properly.
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| Strategy for Future Research Activity |
<Optimization of a detector>
We plan to optimize the front-end and amplifier boards to improve the detector performance in terms of energy resolution and timing resolution.
<Develop a prototype PET scanner>
We plan to develop a prototype full-ring PET system with the optimized front-end electronics.The performance of the full-ring PET system will be evaluated with the NEMA-NU4 protocol and resolution phantom imaging.
In addition, we plan to perform in vivo mouse brain imaging with the developed PET scanner.
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