| Project/Area Number |
23K19220
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0403:Biomedical engineering and related fields
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| Research Institution | Kyushu University |
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Principal Investigator |
WEN PANYUE 九州大学, 先導物質化学研究所, 学術研究員 (00976623)
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| Project Period (FY) |
2023-08-31 – 2025-03-31
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| Project Status |
Granted (Fiscal Year 2023)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2024: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | poly(2-oxazoline) / medical devices / Biocompatible coatings / Medical devices / Biocompatibility / Polymer / Polyoxazoline |
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| Outline of Research at the Start |
New poly(2-oxazoline)-based pseudo-peptido-coating (PP-coating) is proposed as biocompatible coating for high performance medical devices. The new poly(2-oxazoline) coating is expected to have strong hydration ability. The hydration can be further fine-tuned through changing the carbon number of alkyl group at side chain of poly(2-oxazoline), thus enabling PP-coating to maintain improved biocompatibility even working in the long-term.
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| Outline of Annual Research Achievements |
We successfully prepared a new poly(2-oxazoline), poly(2-ethoxycarbonylethyl-2-oxazoline) and applied coating to several common substrate materials of medical devices including PMMA, PP, PS, PC, and PET. The small contact angle clearly indicates that our new poly(2-oxazoline) coating is more hydrophilic than PMEA coating [~25° for poly(2-oxazoline) vs ~45° for PMEA].
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
The Institute for Materials Chemistry and Engineering (IMCE) is an international research institute at Kyushu University promoting research related to the basic science and application of the structure and functions of materials from an atomic, molecular, to supramolecular scale. Particularly, the PI is now working in Prof. Masaru Tanaka Lab. Prof. Tanaka is an expert in the field of biocompatible materials and will provide advisory suggestions for this research. The multidisciplinary and international research team is organized in IMCE.These advanced facilities and multidisciplinary and international team would lay a solid foundation to achieve the research goal.
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| Strategy for Future Research Activity |
The applicant already synthesized one poly(2-oxazoline) and confirmed it can be solubilized in ethanol, allowing methanol-free operation. These preliminary results show that the proposed pseudo-peptido-coating is promising to serve as biocompatible coating for medical devices. The applicant will further control the structure of poly(2-oxazoline) and study performance in details including long-term efficacy, to find the best candidate of pseudo-peptido-coating.
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