Poly(2-oxazoline)-based pseudo-peptido-coating to improve the long-term biocompatibility of medical devices

• Project/Area Number: 23K19220
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0403:Biomedical engineering and related fields
• Research Institution: Kyushu University
• Principal Investigator: WEN PANYUE 九州大学, 先導物質化学研究所, 学術研究員 (00976623)
• Project Period (FY): 2023-08-31 – 2025-03-31
• Project Status: Granted (Fiscal Year 2023)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2024: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: Biocompatible coatings / Medical devices / Biocompatibility / Polymer / Polyoxazoline

Outline of Research at the Start

New poly(2-oxazoline)-based pseudo-peptido-coating (PP-coating) is proposed as biocompatible coating for high performance medical devices. The new poly(2-oxazoline) coating is expected to have strong hydration ability. The hydration can be further fine-tuned through changing the carbon number of alkyl group at side chain of poly(2-oxazoline), thus enabling PP-coating to maintain improved biocompatibility even working in the long-term.