pH‐responsive micelles with lower immunogenicity for smart drug delivery

• Project/Area Number: 23K19230
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0403:Biomedical engineering and related fields
• Research Institution: Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine
• Principal Investigator: Mohamed Aziz・Awaad・Aziz 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 研究員 (50978286)
• Project Period (FY): 2023-08-31 – 2025-03-31
• Project Status: Granted (Fiscal Year 2023)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2024: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: polycarboxybetaine / pH-responsive / anti-tumor / immunogenicity

Outline of Research at the Start

For effective tumor targeting and smart drug delivery, the pH-responsive PGLu(DET-Car)-based polymeric micelles will be used for tumor therapy. The obtained data from this protocol will introduce detailed information about smart nanocarriers used for anti-tumor drug delivery systems development.