The ubiquitin code in intracellular toxic aggregate formation under aging-related stresses

Research Project

Project/Area Number	23K19350
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Multi-year Fund
Review Section	0701:Biology at molecular to cellular levels, and related fields
Research Institution	Osaka University
Principal Investigator	Kaypee StephanieRoshni 大阪大学, 大学院生命機能研究科, 特任研究員(常勤) (40978863)
Project Period (FY)	2023-08-31 – 2025-03-31
Project Status	Granted (Fiscal Year 2023)
Budget Amount *help	¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000) Fiscal Year 2024: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	ubiquitin code / protein aggregates / aging / E3 ligase
Outline of Research at the Start	Protein misfolding and aggregation result in aging-related diseases. Ubiquitination regulates this process but the mechanism is unknown. We aim to decipher the ubiquitin codes on aggregates using mass spectrometry and nanobodies to identify therapeutic targets for aging and stress-related diseases.