| Project/Area Number |
23K19416
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0704:Neuroscience, brain sciences, and related fields
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
BallesterRoig MariaNeus 国立研究開発法人理化学研究所, 生命機能科学研究センター, 特別研究員 (50981536)
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| Project Period (FY) |
2023-08-31 – 2025-03-31
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| Project Status |
Granted (Fiscal Year 2023)
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| Budget Amount *help |
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2024: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2023: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | Sleep / Slow wave / cerebral cortex / ion channels / molecule interactions |
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| Outline of Research at the Start |
Sleep quality and its health benefits are defined by slower frequency of neuronal synchronization. This project studies which cellular ion channels regulate sleep quality from the cerebral cortex. In year 1, ion channels will be mutated in cell cultures of cortical neurons, and the effect on neuronal synchronization is analyzed with microelectrodes. In year two, ion channels are mutated in adult mice and sleep time and quality is studied via the electroencephalogram. Also in year two, the impact of extended wakefulness on molecular aggregations formed by ion channels in the brain is analyzed.
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