Elucidation of the effects of STB/HAP1 in modulating/protecting steroid hormone functions by acting on their receptors in the brain using genetically-modified mice
| Project/Area Number |
23K19456
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0802:Biomedical structure and function and related fields
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Project Period (FY) |
2023-08-31 – 2025-03-31
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| Project Status |
Granted (Fiscal Year 2023)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2024: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | HAP1 / steroid / Brain / rodent / Steroid hormone / Stigmoid body |
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| Outline of Research at the Start |
1. Elucidation of the relationships of STB/HAP1 with Steroid hormone receptors in vivo.
2. Assessments of effects of STB/HAP1 on serum hormone concentration.
3. Examination of effects of STB/HAP1 on the number of SHR-immunoreactive neurons.
4. Clarification of the effects of STB/HAP1 and steroid hormone-related functions.
5. Action in the event that the research does not progress as originally planned.
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| Outline of Annual Research Achievements |
Our previous in vitro findings suggest that STB/HAP1 could be related to the subcellular regulation of SHRs. In this research project to clarify the in vivo effects of STB/HAP1 in regulating or protecting the functions of sex steroids via their receptors; AR and ER, I examined the detailed in vivo immunohistochemical relationships of HAP1 with AR, and ER in the preoptic area and hypothalamic areas in adult mice. I found that HAP1 was highly coexpressed with both the sex steroid receptors in the different brain regions, which is suggestive of HAP1 modification of the steroidal functions in the brain.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
I have completed my first objective, clarifying the in vivo relationships of STB/HAP1 with different steroid receptors. I have presented my research findings at several academic conferences.
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| Strategy for Future Research Activity |
1. Assessments of effects of STB/HAP1 on serum hormone concentration.
2. Examination of effects of STB/HAP1 on the number of SHR-immunoreactive neurons.
3. Clarification of the effects of STB/HAP1 and steroid hormone-related functions.
4. Action if the research has yet to progress as planned initially.
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Report
(1 results)
Research Products
(12 results)
