Effects of Phthalate Exposure on the Hand Digit (2D4D) Ratio, Puberty Onset and Its Underlying Mechanism in 14- to 17-Year-Old Children

Research Project

Project/Area Number	23K19884
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Multi-year Fund
Review Section	0909:Sports sciences, physical education, health sciences, and related fields
Research Institution	Hokkaido University
Principal Investigator	MEGASARI MARSELA 北海道大学, 保健科学研究院, 博士研究員 (60978914)
Project Period (FY)	2023-08-31 – 2025-03-31
Project Status	Granted (Fiscal Year 2023)
Budget Amount *help	¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000) Fiscal Year 2024: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	Phtalate exposure / Children / Hokkaido Study / Puberty Onset / Hand Digit (2D4D) Ratio
Outline of Research at the Start	Phthalate exposure might delay the puberty onset of children and alter the 2D4D ratio. The underlying mechanisms are mediated by the following disruptions, including lowering the reproductive hormones and lowering the level of IGF-1, and osteocalcin due to phthalates exposure.