Deepening and new development of mathematical study on cell adhesion

• Project/Area Number: 23K20226
• Project/Area Number (Other): 20H01823 (2020-2023)
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Multi-year Fund (2024); Single-year Grants (2020-2023)
• Section: 一般
• Review Section: Basic Section 12040:Applied mathematics and statistics-related
• Research Institution: Ryukoku University
• Principal Investigator: 村川 秀樹 龍谷大学, 先端理工学部, 教授 (40432116)
• Co-Investigator(Kenkyū-buntansha): 野津 裕史 金沢大学, 数物科学系, 教授 (00588783) ; 佐藤 純 金沢大学, 新学術創成研究機構, 教授 (30345235) ; 富樫 英 神戸大学, 医学研究科, 助教 (90415240)
• Project Period (FY): 2020-04-01 – 2025-03-31
• Project Status: Declined (Fiscal Year 2024)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2024: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2023: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2022: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2021: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2020: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
• Keywords: 応用数学 / 数値解析学 / 数理生物学 / 細胞接着 / 細胞選別

Outline of Research at the Start

細胞同士の接着である細胞接着、細胞が自発的に適切な組織や器官などの構造を作る細胞選別の理解は、生命科学分野における極めて重要な研究課題である。本研究では、細胞接着及び細胞選別現象に関して、数十万から数百万の細胞数からなる組織レベルの巨視的現象、数十から数百程度の細胞数からなる細胞レベルの微視的現象の双方について、数理モデリング、数値解析、数理解析、生命科学の現場における問題の解明に向けた応用を行う。

Outline of Annual Research Achievements

細胞接着及び細胞選別現象について、数十万から数百万の細胞数からなる組織レベルの巨視的現象、数十から数百程度の細胞数からなる細胞レベルの微視的現象の双方について研究を行っている。微視的現象の数理モデリング研究については、前年度までに完遂しており、本年度は、その応用について検討を進めた。巨視的現象に対する研究については次のようにいくつかの進展があった。
1) 細胞選別現象に対する数理モデルを簡略化した2成分偏微分方程式系について時間離散化を行い、その時間離散スキームについての解析を進めた。
2) 細胞接着に基づく細胞選別現象は、細胞同士の直接の接触に起因する走性、いわば走触性によって引き起こされる。細胞接着に対する細胞集団モデルでは、非局所移流項によって走触性が表現されている。一方で、細胞が産生する化学物質を介して他の細胞とコンタクトを取り、適切な場所に移動する細胞の性質は走化性と呼ばれる。これは、局所的な偏微分方程式によって記述される。走触性現象と走化性現象には、相違点もあれば、共通点もある。これらの相違点や共通点を数理的に解析することにより、現象の数理的構造の解明に近づくことができる。本年度は、この共通点についての解析を進めるために、簡略化した問題を空間1次元において考察し、解析的結果を得た。簡略化しない問題及び空間多次元問題の解析についても検討を行った。
3) 生物の脳の神経細胞はカラム構造と呼ばれる円柱状の構造を作っており、多数のカラムが六角格子状に規則的に並ぶことによって、脳の複雑な処理を可能にしている。カラム構造は脳の機能単位であり、カラム構造形成のメカニズム、カラム配列のメカニズムを理解することは神経科学における重要な研究課題である。昨年度に引き続き、カラム配列のメカニズムの解明に数理モデリングと数値実験の立場から研究した。

Research Progress Status

令和5年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和5年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] University of Oxford(英国)
• [Int'l Joint Research] Technical University Dresden(ドイツ)
• [Int'l Joint Research] University of Lyon(フランス)
• [Int'l Joint Research] University of Oxford(英国)
• [Int'l Joint Research] Technical University Dresden(ドイツ)
• [Int'l Joint Research] University of Oxford(英国)
• [Int'l Joint Research] Technical University Dresden(ドイツ)
• [Int'l Joint Research] University of the Philippines Diliman(フィリピン)
• [Int'l Joint Research] University of Oxford(英国)
• [Int'l Joint Research] Universite de Lille(フランス)
• [Int'l Joint Research] Technische Universitat Dresden(ドイツ)
• [Journal Article] An energy estimate and a stabilized Lagrange-Galerkin scheme for a multiphase flow model (2024)
  • Author(s): Rudiawan Aufa, Zak Alexander, Benes Michal, Kimura Masato, Notsu Hirofumi
  • Journal Title: Applied Mathematics Letters Volume: 153 Pages: 109059-109059
  • DOI: 10.1016/j.aml.2024.109059
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] From soap bubbles to multicellular organisms: Unraveling the role of cell adhesion and physical constraints in tile pattern formation and tissue morphogenesis (2024)
  • Author(s): H. Togashi, S. R. Davis, M. Sato
  • Journal Title: Developmental Biology Volume: 506 Pages: 1-6
  • DOI: 10.1016/j.ydbio.2023.11.007
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Numerical Solution to a Free Boundary Problem for the Stokes Equation Using the Coupled Complex Boundary Method in Shape Optimization Setting (2023)
  • Author(s): Rabago Julius Fergy Tiongson、Notsu Hirofumi
  • Journal Title: Applied Mathematics & Optimization Volume: 89 Issue: 1 Pages: 2-2
  • DOI: 10.1007/s00245-023-10065-7
  • Peer Reviewed
• [Journal Article] ハエからヒトまで共通する神経回路形成機構 (2023)
  • Author(s): 佐藤 純
  • Journal Title: Clinical Neuroscience Volume: 12 Pages: 1556-1561
• [Journal Article] A Two-Step Lagrange?Galerkin Scheme for the Shallow Water Equations with a Transmission Boundary Condition and Its Application to the Bay of Bengal Region?Part I: Flat Bottom Topography (2023)
  • Author(s): Rasid Md Mamunur、Kimura Masato、Murshed Md Masum、Wijayanti Erny Rahayu、Notsu Hirofumi
  • Journal Title: Mathematics Volume: 11 Issue: 7 Pages: 1633-1633
  • DOI: 10.3390/math11071633
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Tiling mechanisms of the Drosophila compound eye through geometrical tessellation (2022)
  • Author(s): Takashi Hayashi, Takeshi Tomomizu, Takamichi Sushida, Masakazu Akiyama, Shin-Ichiro Ei, Makoto Sato
  • Journal Title: Current Biology Volume: 32 Issue: 9 Pages: 1-9
  • DOI: 10.1016/j.cub.2022.03.046
  • Peer Reviewed / Open Access
• [Journal Article] Cutting edge technologies expose the temporal regulation of neurogenesis in the Drosophila nervous system (2022)
  • Author(s): Sato M., and Suzuki, T.
  • Journal Title: Fly Volume: 16 Issue: 1 Pages: 222-232
  • DOI: 10.1080/19336934.2022.2073158
  • Peer Reviewed / Open Access
• [Journal Article] A Mass-Preserving Two-Step Lagrange?Galerkin Scheme for Convection-Diffusion Problems (2022)
  • Author(s): Futai Kouta、Kolbe Niklas、Notsu Hirofumi、Suzuki Tasuku
  • Journal Title: Journal of Scientific Computing Volume: 92 Issue: 2 Pages: 37-37
  • DOI: 10.1007/s10915-022-01885-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A shape design problem for the Navier?Stokes flow with a convective boundary condition (2022)
  • Author(s): Simon J. S. H、Notsu Hirofumi
  • Journal Title: Computational and Applied Mathematics Volume: 41 Issue: 4 Pages: 167-167
  • DOI: 10.1007/s40314-022-01876-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A shape optimization problem constrained with the Stokes equations to address maximization of vortices (2022)
  • Author(s): Simon John Sebastian、Notsu Hirofumi
  • Journal Title: Evolution Equations & Control Theory Volume: - Issue: 6 Pages: 1873-1902
  • DOI: 10.3934/eect.2022003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A convective boundary condition for the Navier-Stokes equations (2022)
  • Author(s): Simon John Sebastian H.、Notsu Hirofumi
  • Journal Title: Applied Mathematics Letters Volume: 128 Pages: 107876-107876
  • DOI: 10.1016/j.aml.2021.107876
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impacts of manipulating cell sorting on in vitro hair follicle regeneration (2022)
  • Author(s): Kageyama Tatsuto、Anakama Riki、Togashi Hideru、Fukuda Junji
  • Journal Title: Journal of Bioscience and Bioengineering Volume: 134 Issue: 6 Pages: 534-540
  • DOI: 10.1016/j.jbiosc.2022.09.004
  • Peer Reviewed / Open Access
• [Journal Article] Hearing loss in mice with disruption of auditory epithelial patterning in the cochlea (2022)
  • Author(s): Katsunuma Sayaka、Togashi Hideru、Kuno Shuhei、Fujita Takeshi、Nibu Ken-Ichi
  • Journal Title: Frontiers in Cell and Developmental Biology Volume: 10 Pages: 1073830-1073830
  • DOI: 10.3389/fcell.2022.1073830
  • Peer Reviewed / Open Access
• [Journal Article] 内耳の市松模様の細胞パターンは聴覚機能にはたらく (2022)
  • Author(s): 富樫英
  • Journal Title: 科学 Volume: 92(11) Pages: 982-986
• [Journal Article] Mathematical modeling of Notch dynamics in <i>Drosophila</i> neural development (2021)
  • Author(s): Yasugi Tetsuo、Sato Makoto
  • Journal Title: Fly Volume: 16 Issue: 1 Pages: 24-36
  • DOI: 10.1080/19336934.2021.1953363
  • Peer Reviewed / Open Access
• [Journal Article] 細胞選別の数理モデル : ミクロ的視点とマクロ的視点 (2021)
  • Author(s): 村川 秀樹
  • Journal Title: 数理科学 Volume: 59(9) Pages: 30-36
• [Journal Article] Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain (2021)
  • Author(s): Wang Miaoxing、Han Xujun、Liu Chuyan、Takayama Rie、Yasugi Tetsuo、Ei Shin-Ichiro、Nagayama Masaharu、Tanaka Yoshitaro、Sato Makoto
  • Journal Title: Nature Communications Volume: 12 Issue: 1 Pages: 1-15
  • DOI: 10.1038/s41467-021-22442-3
  • Peer Reviewed / Open Access
• [Journal Article] Glial insulin regulates cooperative or antagonistic Golden goal/Flamingo interactions during photoreceptor axon guidance (2021)
  • Author(s): Takechi Hiroki、Hakeda-Suzuki Satoko、Nitta Yohei、Ishiwata Yuichi、Iwanaga Riku、Sato Makoto、Sugie Atsushi、Suzuki Takashi
  • Journal Title: eLife Volume: 10
  • DOI: 10.7554/elife.66718
  • Peer Reviewed / Open Access
• [Journal Article] Second-Order Finite Difference Approximations of the Upper-Convected Time Derivative (2021)
  • Author(s): Medeiros Debora D.、Notsu Hirofumi、Oishi Cassio M.
  • Journal Title: SIAM Journal on Numerical Analysis Volume: 59 Issue: 6 Pages: 2955-2988
  • DOI: 10.1137/20m1364990
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Twin vortex computer in fluid flow (2021)
  • Author(s): Goto Ken、Nakajima Kohei、Notsu Hirofumi
  • Journal Title: New Journal of Physics Volume: 23 Issue: 6 Pages: 063051-063051
  • DOI: 10.1088/1367-2630/ac024d
  • Peer Reviewed / Open Access
• [Journal Article] Fast reaction limit of reaction-diffusion systems (2021)
  • Author(s): H. Murakawa
  • Journal Title: Discrete Contin. Dyn. Syst. Ser. S Volume: 14(3) Issue: 3 Pages: 1047-1062
  • DOI: 10.3934/dcdss.2020405
  • Peer Reviewed
• [Journal Article] Convergence of a Fully Discrete and Energy-Dissipating Finite-Volume Scheme for Aggregation-Diffusion Equations and nonlinear cross-diffusion systems (2020)
  • Author(s): Rafael Bailo, Jose A. Carrillo, Hideki Murakawa and Markus Schmidtchen
  • Journal Title: Math. Models Methods Appl. Sci. Volume: 30(13) Issue: 13 Pages: 2487-2522
  • DOI: 10.1142/s0218202520500487
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 細胞接着パターンの数理解析に向けて (2020)
  • Author(s): 村川秀樹
  • Journal Title: 数理解析研究所講究録 Volume: 2166 Pages: 17-21
• [Journal Article] 細胞間接着の数理モデルとその応用 (2020)
  • Author(s): 村川秀樹
  • Journal Title: 数理解析研究所講究録 Volume: 2165 Pages: 100-104
• [Journal Article] DWnt4 and DWnt10 Regulate Morphogenesis and Arrangement of Columnar Units via Fz2/PCP Signaling in the Drosophila Brain (2020)
  • Author(s): Han Xujun、Wang Miaoxing、Liu Chuyan、Trush Olena、Takayama Rie、Akiyama Takaaki、Naito Toshiki、Tomomizu Takeshi、Imamura Kousuke、Sato Makoto
  • Journal Title: Cell Reports Volume: 33 Issue: 4 Pages: 108305-108305
  • DOI: 10.1016/j.celrep.2020.108305
  • Peer Reviewed / Open Access
• [Journal Article] Dscam1 establishes the columnar units through lineage-dependent repulsion between sister neurons in the fly brain (2020)
  • Author(s): Liu Chuyan、Trush Olena、Han Xujun、Wang Miaoxing、Takayama Rie、Yasugi Tetsuo、Hayashi Takashi、Sato Makoto
  • Journal Title: Nature Communications Volume: 11 Issue: 1 Pages: 4067-4067
  • DOI: 10.1038/s41467-020-17931-w
  • Peer Reviewed / Open Access
• [Journal Article] A continuation method for spatially discretized models with nonlocal interactions conserving size and shape of cells and lattices (2020)
  • Author(s): Ei Shin-Ichiro、Ishii Hiroshi、Sato Makoto、Tanaka Yoshitaro、Wang Miaoxing、Yasugi Tetsuo
  • Journal Title: Journal of Mathematical Biology Volume: 81 Issue: 4-5 Pages: 981-1028
  • DOI: 10.1007/s00285-020-01534-6
  • Peer Reviewed / Open Access
• [Journal Article] Role for phagocytosis in the prevention of neoplastic transformation in Drosophila (2020)
  • Author(s): Zhang Min、Nagaosa Kaz、Nakai Yuji、Yasugi Tetsuo、Kushihiki Masako、Rahmatika Dini、Sato Makoto、Shiratsuchi Akiko、Nakanishi Yoshinobu
  • Journal Title: Genes to Cells Volume: 25 Issue: 10 Pages: 675-684
  • DOI: 10.1111/gtc.12804
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Relationship between haptotaxis and chemotaxis in cell sorting phenomena (2024)
  • Author(s): H. Murakawa
  • Organizer: MATRIX-RIMS Tandem Workshop: Evolutionary Partial Differential Equations and Applications
  • Int'l Joint Research / Invited
• [Presentation] 細胞選別の数理： 走触性と走化性の関係 (2024)
  • Author(s): 村川 秀樹
  • Organizer: 非線形現象の数値シミュレーションと解析2024
  • Invited
• [Presentation] A Keller-Segel type approximation to a population dynamics model of cell-cell adhesion (2024)
  • Author(s): H. Murakawa
  • Organizer: Reaction Diffusion Equations and Nonlinear Dispersive Equations
  • Int'l Joint Research / Invited
• [Presentation] Stabilized Lagrange-Galerkin schemes for viscous and viscoelastic flow problems (2024)
  • Author(s): H. Notsu
  • Organizer: Computational Mathematics and Applications Seminar (Mathematical Institute, University of Oxford, UK)
  • Int'l Joint Research / Invited
• [Presentation] 混相流モデルのための有限要素スキーム (2024)
  • Author(s): A. N. F. Rudiawan, A. Zak, M. Benes, 木村正人, 野津裕史
  • Organizer: 日本数学会（大阪公立大学）
• [Presentation] 物理系の微分方程式を用いたリザバー計算 (2024)
  • Author(s): 野津裕史
  • Organizer: AI・データ利活用研究会 第64回
  • Invited
• [Presentation] Intrinsically disordered regions (IDR) of Afadin regulate junctional compartment formation and positioning of adherens junctions. (2024)
  • Author(s): Hideru Togashi
  • Organizer: JST PRESTO International Symposium
  • Int'l Joint Research / Invited
• [Presentation] Unraveling the Dynamics of Cellular Patterning in Animal Tissues: Insights from Self-Organizing Principles (2024)
  • Author(s): Hideru Togashi
  • Organizer: Institute of Physics, Academia Sinica, Taipei
  • Int'l Joint Research / Invited
• [Presentation] 細胞選別現象における走触性と走化性の関係 (2023)
  • Author(s): 村川秀樹
  • Organizer: 第3回はこだて現象数理研究集会
  • Invited
• [Presentation] A Keller-Segel type approximation to a cell population dynamics model (2023)
  • Author(s): H. Murakawa
  • Organizer: 10th International Congress on Industrial and Applied Mathematics
  • Int'l Joint Research / Invited
• [Presentation] A Keller-Segel type approximation to a nonlocal cell population model (2023)
  • Author(s): H. Murakawa
  • Organizer: Topics on Neuroscience, Collective Migration and Parameter Estimation
  • Int'l Joint Research / Invited
• [Presentation] 多細胞集団の運動を記述する数理モデルに対する近似 (2023)
  • Author(s): 村川秀樹
  • Organizer: 反応拡散系パターンダイナミクスの新展開
  • Invited
• [Presentation] Discretization of a model governing the motion of two cell populations (2023)
  • Author(s): H. Murakawa
  • Organizer: The 13th AIMS Conference on Dynamical Systems
  • Int'l Joint Research / Invited
• [Presentation] A mass-preserving two-step Lagrange-Galerkin scheme for convection-diffusion problems (2023)
  • Author(s): H. Notsu
  • Organizer: Seminar on Partial Differential Equations (Institute of Mathematics, Czech Academy of Sciences, Prague)
  • Int'l Joint Research / Invited
• [Presentation] Reservoir computing with fluid flows (2023)
  • Author(s): H. Notsu, K. Goto, K. Nakajima
  • Organizer: Advances in Computational Mechanics (ACM 2023, The University of Texas at Austin, Austin, Texas, US)
  • Int'l Joint Research / Invited
• [Presentation] A Lagrangian moving mesh method (2023)
  • Author(s): H. Notsu
  • Organizer: Biwako Workshop on Mathematical Biology (Shiga, Japan)
  • Int'l Joint Research / Invited
• [Presentation] 粘弾性流体の数値シミュレーション (2023)
  • Author(s): 野津裕史
  • Organizer: 二軸押出研究会
  • Invited
• [Presentation] 粘弾性流体の数値シミュレーション (2023)
  • Author(s): 野津裕史
  • Organizer: 自己組織化セミナー in 金沢
  • Invited
• [Presentation] 流れを用いたバーチャル物理リザバー計算 (2023)
  • Author(s): 野津裕史
  • Organizer: 複雑系知能セミナー（公立はこだて未来大学）
  • Invited
• [Presentation] A total design of finite element schemes for flow problems (2023)
  • Author(s): H. Notsu
  • Organizer: 北大 MMC セミナー
  • Invited
• [Presentation] 反応拡散モデルと遺伝学実験を組み合わせた多細胞パターン形成機構の解明 (2023)
  • Author(s): 佐藤純
  • Organizer: 反応拡散系パターンダイナミクスの新展開
• [Presentation] Lineage Dependent Column Formation in the fly brain (2023)
  • Author(s): Makoto Sato
  • Organizer: Biwako Workshop on Mathematical Biology
  • Int'l Joint Research / Invited
• [Presentation] 神経系のタイリング機構 (2023)
  • Author(s): 佐藤純
  • Organizer: 脳神経回路の形成・動作と制御の現在と未来
• [Presentation] Tiling mechanisms of the compound eye through geometrical tessellation (2023)
  • Author(s): Makoto Sato
  • Organizer: Mathematical Biology from genes to cells to humans
  • Int'l Joint Research
• [Presentation] Tiling in the nervous system (2023)
  • Author(s): 佐藤純
  • Organizer: 第13回分子高次機能研究会
• [Presentation] 視覚システムの統合機構の解明 (2023)
  • Author(s): 佐藤純
  • Organizer: 数学と脳科学の連携に向けたワークショップ
• [Presentation] Cell-cell communications that control column formation in the fly brain (2023)
  • Author(s): Makoto Sato
  • Organizer: The 3rd Asia Pacific Drosophila Neurobiology Conference
  • Int'l Joint Research
• [Presentation] 数理科学を駆動力とした神経発生研究 (2023)
  • Author(s): 佐藤純
  • Organizer: 第17回神経発生討論会/第20回成体脳のニューロン新生懇談会 合同大会
• [Presentation] The Mosaic Pattern of Sensory Epithelium is Essential for Sensory Function (2023)
  • Author(s): Hideru Togashi
  • Organizer: Biwako workshop on mathematical biology
  • Int'l Joint Research / Invited
• [Presentation] 接着の偏在によるモザイク形成メカニズム (2023)
  • Author(s): 富樫英
  • Organizer: 第7回さきがけ「多細胞」領域会議
  • Invited
• [Presentation] 細胞間接着に関する理論とシミュレーション (2023)
  • Author(s): 村川秀樹
  • Organizer: 生物とソフトマターに関する理論とシミュレーションについての研究会
  • Invited
• [Presentation] Tiling mechanisms of the compound eye through geometrical tessellation (2023)
  • Author(s): Hayashi, T., Sushida, T., Akiyama, M., Ei, S., and Sato, M.
  • Organizer: 64th Annual Drosophila Research Conference
  • Int'l Joint Research
• [Presentation] An approximation to a model governing the motion of two cell population (2022)
  • Author(s): H. Murakawa
  • Organizer: RIMS Symposium Mathematical Analysis on pattern formation, propagation and interfacial phenomena
  • Int'l Joint Research / Invited
• [Presentation] Bi-directional Eph/Ephrin signaling organizes the columnar structure under the control of Neurexin in the fly brain (2022)
  • Author(s): Wang, M., Sato, M.
  • Organizer: Japanese Society of Developmental Biologists
  • Int'l Joint Research
• [Presentation] Tiling mechanisms of the compound eye through geometrical tessellation (2022)
  • Author(s): Hayashi, T., Sushida, T., Akiyama, M., Ei, S., and Sato, M.
  • Organizer: Neuro2022
  • Int'l Joint Research
• [Presentation] 幾何学分割による複眼のタイリング機構 (2022)
  • Author(s): 佐藤 純
  • Organizer: 日本視覚学会
  • Invited
• [Presentation] 移流拡散問題のための質量保存2段 Lagrange-Galerkin スキーム (2022)
  • Author(s): 野津裕史, 二井滉太, N. Kolbe, 鈴木佑
  • Organizer: RIMS Workshop
  • Invited
• [Presentation] A mass-preserving two-step Lagrange-Galerkin scheme for convection-diffusion problems (2022)
  • Author(s): H. Notsu, K. Futai, N. Kolbe, T. Suzuki
  • Organizer: RIMS Workshop
  • Invited
• [Presentation] Second-order finite difference approximations of the upper-convected time derivative (2022)
  • Author(s): H. Notsu, D.O. Medeiros, C.M. Oishi
  • Organizer: WCCM-APCOM 2022
  • Int'l Joint Research / Invited
• [Presentation] Twin vortex computer in fluid flow and a related topic (2022)
  • Author(s): H. Notsu
  • Organizer: RIMS Workshop
  • Int'l Joint Research / Invited
• [Presentation] 聴覚上皮の市松模様の細胞パターンと聴覚機能 (2022)
  • Author(s): Hideru Togashi
  • Organizer: 第3回 「医学と数理」京大-ハイデルベルク大-理研 ワークショップ
  • Int'l Joint Research / Invited
• [Presentation] Three different domains of afadin independently regulate cell intercalation in nectin-dependent mosaic cellular patterning (2022)
  • Author(s): Shuhei Kuno, Tetsuhisa Otani, Akira Suzuki, Hideru Togashi
  • Organizer: 55th Annual Meeting of the Japanese Society of Developmental Biologists
  • Int'l Joint Research
• [Presentation] Molecular interactions between p120 catenin and cadherin regulate junction shrinkage of heterotypic interfaces during cadherin-dependent cell sorting (2022)
  • Author(s): Hideru Togashi
  • Organizer: 55th Annual Meeting of the Japanese Society of Developmental Biologists
  • Int'l Joint Research
• [Presentation] 「市松模様を作る細胞」実験生物学と理論のDUOトーク (2022)
  • Author(s): 村川秀樹
  • Organizer: 生物多様性コロキウム (MACS共催)
  • Invited
• [Presentation] 細胞間接着の数理モデリング とその応用 (2021)
  • Author(s): 村川秀樹
  • Organizer: 複雑系知能セミナー
  • Invited
• [Presentation] Micro-and macroscopic models for cell sorting (2021)
  • Author(s): 村川秀樹
  • Organizer: CREST 「現代の数理科学と連携するモデリング手法の構築」 成果報告公開シンポジウム 2021
• [Presentation] 細胞選別の数理モデル：ミクロ的視点とマクロ的視点 (2021)
  • Author(s): 村川秀樹
  • Organizer: 2021年度 日本数理生物学会年会
• [Presentation] Mathematical models of cell sorting: micro- and macroscopic perspectives (2021)
  • Author(s): H. Murakawa
  • Organizer: 54th Annual Meeting of Japan Society of Developmental Biologists
  • Int'l Joint Research
• [Presentation] Tiling mechanisms of the compound eye through geometrical tessellation (2021)
  • Author(s): M. Sato
  • Organizer: The 51st NIPS International Symposium
  • Int'l Joint Research
• [Presentation] Dscam1 regulates column formation through lineage-dependent repulsion 13th GfE school (2021)
  • Author(s): M. Sato
  • Organizer: Stem cells, development, and regeneration: the emergence of new tissues
  • Int'l Joint Research
• [Presentation] Tiling mechanisms of the compound eye through geometrical tessellation (2021)
  • Author(s): M. Sato
  • Organizer: RIMS Workshop, Mathematical Mechanobiology
  • Int'l Joint Research
• [Presentation] Twin vortex computer in fluid flow (2021)
  • Author(s): H. Notsu, K. Goto, K. Nakajima
  • Organizer: International Conference: Differential Equations for Data Science 2021 (DEDS2021)
  • Int'l Joint Research / Invited
• [Presentation] 感覚器における『市松模様』の細胞パターンを制御する分子機構 (2021)
  • Author(s): 富樫英
  • Organizer: 京都大学理学研究科 生物多様性コロキウム
  • Invited
• [Presentation] 細胞パターン形成における細胞間相互作用と接着分子のダイナミクス (2021)
  • Author(s): 富樫英
  • Organizer: 第73回 日本細胞生物学会大会
  • Invited
• [Presentation] 上皮組織形成の数理モデルと数値解法 (2021)
  • Author(s): 村川秀樹
  • Organizer: 日本数学会2021年度年会
• [Presentation] 曲面上における反応拡散系シミュレーション (2021)
  • Author(s): 井上広也, 村川秀樹
  • Organizer: 2020年度龍谷大学武蔵野大学連携シンポジウム
  • Invited
• [Presentation] DWnt4 and DWnt10 globally regulate morphogenesis and arrangement of the columnar structures through Fz2/PCP signaling in the fly brain (2021)
  • Author(s): Sato, M.
  • Organizer: Wnt研究会
• [Presentation] 感覚器におけるモザイク様細胞パターン形成の数理モデルと数値解法 (2020)
  • Author(s): 村川秀樹
  • Organizer: 2020年度応用数学合同研究集会
• [Presentation] 細胞選別現象の解明に向けた数理モデリングとその解析 (2020)
  • Author(s): 村川秀樹
  • Organizer: 楕円型・放物型微分方程式研究集会
  • Invited
• [Presentation] Mathematical models of cell-cell adhesion: macro- and microscopic perspectives (2020)
  • Author(s): H. Murakawa
  • Organizer: Micro-to-Macro Modelling in Developmental Biology
  • Int'l Joint Research / Invited
• [Presentation] 非線形非局所Fokker-Planck型方程式に対するエネルギー散逸有限体積スキーム (2020)
  • Author(s): 村川秀樹
  • Organizer: 2020年度秋季総合分科会
• [Presentation] 細胞間接着の数理：モデリング, 数値解析, 応用 (2020)
  • Author(s): 村川秀樹
  • Organizer: 京都応用数学セミナー
  • Invited
• [Presentation] 不均質な多孔質媒体内の流れの安定性と数値計算 (2020)
  • Author(s): 野津裕史
  • Organizer: 京都駅前セミナー
  • Invited
• [Presentation] Fz2/PCP signaling regulates the morphogenesis and arrangement of the columnar structures in the fly brain (2020)
  • Author(s): Sato, M.
  • Organizer: JSDB Online Trial Meeting 2020
• [Presentation] Tiling mechanisms of the compound eye (2020)
  • Author(s): Sato, M.
  • Organizer: Micro-to-Macro Modelling in Developmental Biology
  • Int'l Joint Research / Invited
• [Presentation] Tiling mechanisms of the compound eye (2020)
  • Author(s): Sato, M.
  • Organizer: An International Webinar Series on Arthropod Sensory Organs
  • Int'l Joint Research / Invited
• [Presentation] ショウジョウバエ視覚系におけるタイリングメカニズム (2020)
  • Author(s): 佐藤 純, 林 貴史, 秋山 正和, 栄 伸一郎, 須志田 隆道
  • Organizer: 第43回日本分子生物学会年会 ワークショップ 「分子生物学を超えた形作りの基本原理」
  • Invited
• [Presentation] Asymmetric distribution of cadherin-catenin complex drives cell intercalations in nectin-dependent mosaic cellular pattern formation (2020)
  • Author(s): S. Kuno, S. Katsunuma, A. Suzuki and H. Togashi
  • Organizer: 53rd Annual meeting of the Japanese Society of Developmental Biologists
• [Presentation] 異なるネクチンの細胞間相互作用は、カドヘリン・カテニン複合体の偏在を作り出すことで2種類の細胞のモザイクパターンを形成する (2020)
  • Author(s): 富樫英
  • Organizer: 第72回 日本細胞生物学会大会
  • Invited
• [Presentation] 自己組織的な極性形成によるモザイクパターン形成 (2020)
  • Author(s): 富樫英
  • Organizer: 細胞極性研究会
• [Presentation] Cellular interactions and molecular dynamics in mosaic cellular pattern formation (2020)
  • Author(s): H.Togashi
  • Organizer: 第43回 日本分子生物学会年会
  • Invited
• [Book] いますぐ始める数理生命科学-MATLABプログラミングからシミュレーションまで- (2021)
  • Author(s): 佐藤 純
  • Total Pages: 256
  • Publisher: コロナ社
  • ISBN: 9784339067620
• [Funded Workshop] Biwako Workshop on Mathematical Biology (2023)
• [Funded Workshop] RIMS Conference「Multidisciplinary Research on Nonlinear Phenomena: Modeling, Analysis and Applications」 (2023)