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Targeting microglia to elucidate the molecular pathogenesis of neurodegenerative diseases and establish therapeutic strategies.

Research Project

Project/Area Number 23K21397
Project/Area Number (Other) 21H02812 (2021-2023)
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeMulti-year Fund (2024)
Single-year Grants (2021-2023)
Section一般
Review Section Basic Section 51030:Pathophysiologic neuroscience-related
Research InstitutionKeio University

Principal Investigator

伊東 大介  慶應義塾大学, 医学部(信濃町), 特任教授 (80286450)

Co-Investigator(Kenkyū-buntansha) 西本 祥仁  慶應義塾大学, 医学部(信濃町), 講師 (30398622)
Project Period (FY) 2021-04-01 – 2025-03-31
Project Status Granted (Fiscal Year 2024)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2024: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2023: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2022: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2021: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Keywords神経変性疾患 / 炎症 / 遺伝子改変マウス / ミクログリア / 認知症 / 筋萎縮性側索硬化症 / 前頭側頭型認知症
Outline of Research at the Start

近年、アルツハイマー病(AD)を始めとする神経変性疾患の病態において、炎症とミクログリアの重要性が明らかとなりつつある. 一方、脳の炎症の中核を担うミクログリアの活性過程の分子メカニズムは未だ不明のままである. 申請者らが同定したミクログリア特異的カルシウム結合蛋白Iba1は、ミクログリアの活性化時に鋭敏に誘導されるが、活性化の分子スイッチとしての役割は検討されていない. 本研究では、神経変性におけるミクログリア/炎症の分子病態解明を目指し、3つの遺伝子改変マウスを樹立して新規治療標的の同定を目標とする.

Outline of Annual Research Achievements

近年、アルツハイマー病(AD)を始めとする神経変性疾患の病態において、炎症とミクログリアの重要性が明らかとなりつつある. 申請者らが同定したミクログリア特異的カルシウム結合蛋白Iba1は、ミクログリアの活性化時に鋭敏に誘導されるが、活性化の分子スイッチとしての役割は検討されていない. 本研究では、神経変性におけるミクログリア/炎症の分子病態解明を目指し、3つの遺伝子改変マウスを樹立して新規治療標的の同定を目標とする.
AIM1: Iba1-KOマウスをゲノム編集で作成し、アルツハイマー病、タウオパチーモデルマウスとの交配を始めている。
AIM2: 抗IgLON5抗体脳症は、睡眠障害、進行性核上性麻痺と類似した嚥下障害や歩行障害、認知機能障害、不安などの精神症状と亜急性に脳幹被蓋部にタウ蛋白が蓄積することが特徴である. 我々はIgLON5-KOを作成、表現型の解析を行った. IgLON5-KOマウスは野生型に比べ、運動機能検査であるワイヤーハングテストやロータロッドテストの成績が劣っていた。さらに、IgLON5-KOマウスは、open-field testなどの行動試験において、不安様行動や多動性が低下した。また、IgLON5/-マウスは、文脈的恐怖条件付け試験において、遠隔記憶が不良であった。しかし、脳波による睡眠障害やタウ凝集(hTau.P301S (Tg2541)との交配)は検出されなかった。これらの結果は、IgLON5が活動性、不安、運動能力、文脈的恐怖記憶と関連していることを示唆している。
AIM3:新規筋萎縮性側策硬化症モデルマウスとしてゲノム編集マウス(FUS-H517D)の解析を進めている.歩行解析とRotarodで歩行異常を認め,組織学的評価では脊髄前角の運動ニューロンの減少やFUSタンパク質の核内から細胞質への局在変化など明白な表現型を認めている。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

AIM1:Iba1-KO マウスは既に樹立しており、現在計画繁殖の下、網羅的行動解析を行っている。また、アルツハイマー病モデルマウス(AppNL-G-F/NL-G-F )、タウオパチーモデルマウス(hTau.P301S (Tg2541))との交配を始めている。
AIM2: IgLON5ノックアウトマウスの表現型解析和終了し、IgLON5が活動性、不安、運動能力、文脈的恐怖記憶と関連していることを示した。一方、hTau.P301S (Tg2541)との交配から、IgLON5は、タウのホメオスタシスには直積関与していない可能性が示唆された。抗IgLON5病の様々な表現型を比較すると、抗IgLON5病は部分的にIgLON5の機能喪失と関連している可能性がある。しかし、睡眠障害やタウ凝集などの他の表現型は、IgLON5の機能獲得や/炎症による神経細胞損傷によって引き起こされる可能性がある。本内容は、Neurol Neuroimmunol Neuroinflammに掲載された(doi:10.1212/NXI.0000000000200234)
AIM3:新規筋萎縮性側策硬化症モデルマウスとして、ゲノム編集マウス(FUS-H517D)を作成した.歩行解析(DigiGait解析)とRotarodで歩行異常を認め,組織学的評価では脊髄(腰髄)前角の運動ニューロンの減少やFUSタンパク質の核内から細胞質への局在変化など明白な表現型を認めている.また,病初期から脊髄(腰髄)前角の運動ニューロンにおける核膜・核膜孔の顕著な歪みを観察した。

Strategy for Future Research Activity

AIM1:Iba1-KOマウスは,発達過程の評価のため行動学的,組織学的検討を推進している.行動解析としては,運動機能:Rota-rod,hanging wire test,認知機能:不安様行動 (open field),空間作業記憶 (Y maze),文脈記憶 (Trace fear conditioning test),社交性の障害(3 chambers test)を検討する. 神経系形態学的検討は詳細に進め,神経発生,正常脳組織におけるミクログリアIba1の役割を明らかにする. また,電子顕微鏡にて髄鞘の構造の変化,特にMcNamaraらの報告で見られたinner tongueの増大やミエリンの肥厚などを評価する. さらに,Single cell RNA-seq解析にて,ミクログリアを含めた各細胞の特徴的な遺伝子発現プロファイルの変化を明らかにする.
Iba1-KO マウスは、アルツハイマー病モデルマウス、タウオパチーモデルマウス、ALSモデルマウスマウスとの交配により海馬、大脳皮質でのアミロイドβ、タウ/FUS蓄積の出現、神経細胞死、不溶性タウ/FUSを定量的に評価する. 運動解析、認知機能の解析を行う。
AIM3:ALSモデルマウス(FUS-H517D)における空間オミックス解析(spatial transcriptomics)を計画しているこれにより,細胞間相互作用や組織内の細胞組織構造など立体的な遺伝子発現パターンの特徴を捉えることが可能となり,ALSモデルマウスにおいて,経時的に空間オミックス解析を行い,核膜・核膜孔の障害の詳細なメカニズムを明らかにすることができる.具体的には,核膜・核膜孔の形態異常が認められる運動ニューロンと認められない運動ニューロンにおける遺伝子発現の相違点を評価することで,核膜・核膜孔の保護目的とした新規治療ターゲットを同定する.

Report

(3 results)
  • 2023 Annual Research Report
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • Research Products

    (45 results)

All 2024 2023 2022 2021 Other

All Journal Article (20 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 20 results,  Open Access: 18 results) Presentation (23 results) (of which Int'l Joint Research: 11 results,  Invited: 6 results) Remarks (2 results)

  • [Journal Article] Decreased short-latency afferent inhibition in individuals with mild cognitive impairment: A TMS-EEG study2024

    • Author(s)
      Mimura Yu、Tobari Yui、Nakajima Shinichiro、Takano Mayuko、Wada Masataka、Honda Shiori、Bun Shogyoku、Tabuchi Hajime、Ito Daisuke、Matsui Mie、Uchida Hiroyuki、Mimura Masaru、Noda Yoshihiro
    • Journal Title

      Progress in Neuro-Psychopharmacology and Biological Psychiatry

      Volume: 132 Pages: 110967-110967

    • DOI

      10.1016/j.pnpbp.2024.110967

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Phenotypic Insights Into Anti-IgLON5 Disease in IgLON5-Deficient Mice2024

    • Author(s)
      Lee Sin Yi、Shoji Hirotaka、Shimozawa Aki、Aoyagi Hirofumi、Sato Yoshiaki、Tsumagari Kazuya、Terumitsu Mika、Motegi Haruhiko、Okada Kensuke、Sekiguchi Koji、Kuromitsu Junro、Nakahara Jin、Miyakawa Tsuyoshi、Ito Daisuke
    • Journal Title

      Neurology Neuroimmunology & Neuroinflammation

      Volume: 11 Issue: 3

    • DOI

      10.1212/nxi.0000000000200234

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery2023

    • Author(s)
      Morimoto Satoru、Takahashi Shinichi、Ito Daisuke et al.
    • Journal Title

      Cell Stem Cell

      Volume: 30 Issue: 6 Pages: 766-780.e9

    • DOI

      10.1016/j.stem.2023.04.017

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential toxicity and localization of arginine-rich C9ORF72 dipeptide repeat proteins depend on de-clustering of positive charges2023

    • Author(s)
      Miyagi Tamami、Ueda Koji、Sugimoto Masahiro、Yagi Takuya、Ito Daisuke、Yamazaki Rio、Narumi Satoshi、Hayamizu Yuhei、Uji-i Hiroshi、Kuroda Masahiko、Kanekura Kohsuke
    • Journal Title

      iScience

      Volume: 26 Issue: 6 Pages: 106957-106957

    • DOI

      10.1016/j.isci.2023.106957

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Performance of plasma Aβ42/40, measured using a fully automated immunoassay, across a broad patient population in identifying amyloid status2023

    • Author(s)
      Bun Shogyoku、Ito Daisuke、Tezuka Toshiki、Kubota Masahito、Ueda Ryo、Takahata Keisuke、Moriguchi Sho、Kurose Shin、Momota Yuki、Suzuki Natsumi、Morimoto Ayaka、Hoshino Yuka、Seki Morinobu、Mimura Yu、Shikimoto Ryo、Yamamoto Yasuharu、Hoshino Takayuki、Sato Yoshiaki、Tabuchi Hajime、Mimura Masaru
    • Journal Title

      Alzheimer's Research & Therapy

      Volume: 15 Issue: 1 Pages: 149-149

    • DOI

      10.1186/s13195-023-01296-5

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of Amyloid and Tau PET on Changes in Diagnosis and Patient Management2023

    • Author(s)
      Shimohama S, Tezuka T, Keisuke T, Bun S, Tabuchi H, Seki M, Momota Y, Suzuki N, Morimoto A, Iwabuchi Y, Kubota M, Yamamoto Y, Sano Y, Shikimoto R, Funaki K, Mimura Y, Nishimoto Y, Ueda R, Jinzaki M, Nakahara J, Mimura M, Ito D
    • Journal Title

      Neurology

      Volume: 100 Issue: 3

    • DOI

      10.1212/wnl.0000000000201389

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Case report: Non-Alzheimer's disease tauopathy with logopenic variant primary progressive aphasia diagnosed using amyloid and tau PET2022

    • Author(s)
      Momota Y, Konishi M, Takahata K, Kishimoto T, Tezuka T, Bun S, Tabuchi H, Ito D, Mimura M.
    • Journal Title

      Frontiers in neurology

      Volume: - Pages: 1049113-1049113

    • DOI

      10.3389/fneur.2022.1049113

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer2022

    • Author(s)
      Shimada Hiroko、Sato Yuta、Sasaki Takashi、Shimozawa Aki、Imaizumi Kent、Shindo Tomoko、Miyao Sachiyo、Kiyama Kosuke、Kondo Takahiro、Shibata Shinsuke、Ishii Seiji、Kuromitsu Junro、Aoyagi Hirofumi、Ito Daisuke、Okano Hideyuki
    • Journal Title

      Cell Reports Methods

      Volume: 2 Issue: 9 Pages: 100289-100289

    • DOI

      10.1016/j.crmeth.2022.100289

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Findings of (18) F-PI-2620 tau PET imaging in patients with Alzheimer's disease and healthy controls in relation to the plasma P-tau181 levels in a Japanese sample2022

    • Author(s)
      Bun S, Moriguchi S, Tezuka T, Sato Y, Takahata K, Seki M, Nakajima S, Yamamoto Y, Sano Y, Suzuki N, Morimoto A, Ueda R, Tabuchi H, Ito D, Mimura M.
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 42 Issue: 4 Pages: 437-448

    • DOI

      10.1002/npr2.12281

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Striatal Dopaminergic Depletion Pattern Reflects Pathological Brain Perfusion Changes in Lewy Body Diseases2022

    • Author(s)
      Iwabuchi Yu、Shiga Tohru、Kameyama Masashi、Miyazawa Raita、Seki Morinobu、Ito Daisuke、Uchida Hiroyuki、Tabuchi Hajime、Jinzaki Masahiro
    • Journal Title

      Molecular Imaging and Biology

      Volume: 24 Issue: 6 Pages: 950-958

    • DOI

      10.1007/s11307-022-01745-x

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Establishment of KEIOi005-A iPSC line from urine-derived cells (UDCs) of a mild Alzheimer's disease (AD) donor with multiple risk SNPs for sporadic Alzheimer's disease (sAD)2022

    • Author(s)
      Sopak Supakul, Nicolas Leventoux, Hajime Tabuchi, Masaru Mimura, Daisuke Ito, Sumihiro Maeda, Hideyuki Okano
    • Journal Title

      Stem Cell Res .

      Volume: 62 Pages: 102802-102802

    • DOI

      10.1016/j.scr.2022.102802

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Progressive Ataxia and Palatal Tremor Showing Characteristic Tau Depositions in [18 F]PM-PBB3 PET.2022

    • Author(s)
      Tezuka T, Takahata K, Tagai K, Ueda R, Ito D, Takeda H, Takahashi S, Nakahara J, Higuchi M, Seki M.
    • Journal Title

      Movement Disorder

      Volume: 37 Issue: 6 Pages: 1317-1319

    • DOI

      10.1002/mds.28983

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maiden voyage: induced pluripotent stem cell-based drug screening for amyotrophic lateral sclerosis2022

    • Author(s)
      Ito Daisuke、Morimoto Satoru、Takahashi Shinichi、Okada Kensuke、Nakahara Jin、Okano Hideyuki
    • Journal Title

      Brain

      Volume: 146 Issue: 1 Pages: 13-19

    • DOI

      10.1093/brain/awac306

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Alpha‐synuclein dynamics in induced pluripotent stem cell‐derived dopaminergic neurons from a Parkinson’s disease patient ( PARK4 ) with SNCA triplication2021

    • Author(s)
      Fukusumi Hayato、Togo Kazuyuki、Sumida Miho、Nakamori Masayuki、Obika Satoshi、Baba Kousuke、Shofuda Tomoko、Ito Daisuke、Okano Hideyuki、Mochizuki Hideki、Kanemura Yonehiro
    • Journal Title

      FEBS Open Bio

      Volume: 11 Issue: 2 Pages: 354-366

    • DOI

      10.1002/2211-5463.13060

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A diagnostic strategy for Parkinsonian syndromes using quantitative indices of DAT SPECT and MIBG scintigraphy: an investigation using the classification and regression tree analysis2021

    • Author(s)
      Iwabuchi Yu、Kameyama Masashi、Matsusaka Yohji、Narimatsu Hidetoshi、Hashimoto Masahiro、Seki Morinobu、Ito Daisuke、Tabuchi Hajime、Yamada Yoshitake、Jinzaki Masahiro
    • Journal Title

      European Journal of Nuclear Medicine and Molecular Imaging

      Volume: - Issue: 6 Pages: 1833-1841

    • DOI

      10.1007/s00259-020-05168-0

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of different parietal hypoperfusion on neuropsychological characteristics in mild cognitive impairment2021

    • Author(s)
      Yamaguchi T, Tabuchi H, Ito D, Saito N, Yamagata B, Konishi M, Takebayashi M, Ikeda M, Mimura M
    • Journal Title

      Psychogeriatrics

      Volume: 21(4) Issue: 4 Pages: 618-626

    • DOI

      10.1111/psyg.12723

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of [18F]PI-2620, a second-generation selective tau tracer, for assessing four-repeat tauopathies2021

    • Author(s)
      Tezuka Toshiki、et al 、Miura Eisuke、Yamamoto Yasuharu、Sano Yasunori、Funaki Kei、Yamagata Bun、Ueda Ryo、Yoshizaki Takahito、Mashima Kyoko、Shibata Mamoru、Oyama Munenori、Okada Kensuke、Kubota Masahito、Okita Hajime、Takao Masaki、Jinzaki Masahiro、Nakahara Jin、Mimura Masaru、Ito Daisuke
    • Journal Title

      Brain Communications

      Volume: 3 Issue: 4

    • DOI

      10.1093/braincomms/fcab190

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Influence of a clinical trial in the decision-making processes of patients with amyotrophic lateral sclerosis2021

    • Author(s)
      Kato Chris、Morimoto Satoru、Takahashi Shinichi、Dat? Yugaku、Okada Kensuke、Okano Hideyuki、Nakahara Jin、Ito Daisuke
    • Journal Title

      Journal of Neurology

      Volume: - Issue: 5 Pages: 2634-2640

    • DOI

      10.1007/s00415-021-10862-6

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Promise of Nucleic Acid Therapeutics for Amyotrophic Lateral Sclerosis2021

    • Author(s)
      Ito Daisuke
    • Journal Title

      Annals of Neurology

      Volume: 91 Issue: 1 Pages: 13-20

    • DOI

      10.1002/ana.26259

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)12021

    • Author(s)
      Daniel J Klionsky、Shu Aizawa、Amal Kamal Abdel-Aziz、Sara Abdelfatah、Mahmoud Abdellatif、Asghar Abdoli、Steffen Abel、Hagai Abeliovich、Marie H Abildgaard、Yakubu Princely Abudu、Abraham Acevedo-Arozena、Iannis E Adamopoulos、Khosrow Adeli、Timon E Adolph、Annagrazia Adornetto、Elma Aflaki、Galila Agam et al.
    • Journal Title

      Autophagy

      Volume: 17 Issue: 1 Pages: 1-382

    • DOI

      10.1080/15548627.2020.1797280

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] プロティノパチーイメージングと体液バイオマーカーに基づく早期認知症診療の確立.2023

    • Author(s)
      伊東大介
    • Organizer
      第38回日本老年精神医学会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 次世代認知症診療におけるプロティノパチーイメージングと体液バイオマーカーの現状と展望.2023

    • Author(s)
      伊東大介
    • Organizer
      第53回日本神経精神薬理学会年会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Prospects for Alzheimer's Disease (AD)-Modifying Drugs and Current Status of AD Biomarkers2023

    • Author(s)
      伊東大介
    • Organizer
      第97回日本薬理学会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] PET imaging of non-Alzheimer neurodegenerative diseases.2023

    • Author(s)
      Ito D.
    • Organizer
      World Federation of Neurology, Specialty Group on Aphasia, Dementia and Cognitive Disorder
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Ropinirole hydrochloride suppresses cholesterol synthetic pathway in ALS spinal motor neurons.2023

    • Author(s)
      Takahashi S, Morimoto S, Kato C, Nakamura S, Ozawa F, Ito D, Okano H.
    • Organizer
      Society for Neuroscience, Annual Meeting 2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Utility evaluation of a tau tracer, [18F]PI-2620, in Alzheimer’s disease (ad) and non-AD tauopathies.2022

    • Author(s)
      Tezuka T, Takahata K, Seki M, Tabuchi H, Ueda R, Momota Y, Suzuki N, Morimoto A, Iwabuchi Y, Miura E, Okita H, Takao M, Kubota M, Yamamoto Y, Sano Y, Jinzaki M, Mimura M, Nakahara J, Ito D
    • Organizer
      2022 International Conference on Alzheimer’s and Parkinson’s Diseases and related neurological disorders
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Bun S, Ito D, Sato Y, Tezuka T, Takahata K, Yamamot Y, Sano Y, Kubota M, Tabuchi H, Mimura M. Amyloid status prediction by combining plasma p-tau181 and NfL cut-offs2022

    • Author(s)
      Bun S, Ito D, Sato Y, Tezuka T, Takahata K, Yamamot Y, Sano Y, Kubota M, Tabuchi H, Mimura M.
    • Organizer
      Alzheimer's Association International Conference
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] プロティノパチーイメージングと体液バイオマーカーに基づく次世代認知症診療体制.2022

    • Author(s)
      伊東大介
    • Organizer
      第41回日本認知症学会学術集会 第37回日本老年精神医学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Impact of Amyloid and Tau PET Combination on Changes in Diagnosis and Management2022

    • Author(s)
      Shimohama S, Tezuka T, Keisuke T, Bun S, Tabuchi H, Seki M, Momota Y, Suzuki N, Morimoto A, Iwabuchi Y, Kubota M, Yamamoto Y, Sano Y, Shikimoto R, Funaki K, Mimura Y, Nishimoto Y, Ueda R, Jinzaki M, Nakahara J, Mimura M, Ito D.
    • Organizer
      第41回日本認知症学会学術集会 第37回日本老年精神医学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Phase 1/2a, Double-blind, Placebo-controlled Study of Ropinirole Hydrochloride Remedy for ALS (ROPALS trial) Based On The iPSC Drug Repositioning.2021

    • Author(s)
      Takahashi S, Morimoto S, Okada K, Date Y, Ito D, Nakahara J, Okano H.
    • Organizer
      American Academy of Neurology
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dementia screening using simple questions and symptoms-News, Consciousness, and Pleasure simple screening questionnaires for dementia (Neucop-Q)2021

    • Author(s)
      Date Y, Sugiyama D, Tabuchi H, Saito N, Konishi M, Eguchi Y, Momota Y, Yoshizaki T, Mashima K, Mimura M, Nakahara J, Ito D.
    • Organizer
      The 15th International Conference on Alzheimer's and Parkinson's Diseases and Related Neurological Disorders
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Phase 1/2a, Double-blind, Placebo-controlled Study of Ropinirole Hydrochloride Remedy for ALS (ROPALS trial) Based On The iPSC Drug Repositioning.2021

    • Author(s)
      Takahashi S, Morimoto S, Okada K, Date Y, Ito D, Nakahara J, Okano H.
    • Organizer
      The 73rd Annual Meeting of the American Academy of Neurology
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ropals trial: phase 1/2a, double-blind, placebo-controlled study of ropinirole hydrochloride for als patients based on the ipsc drug repositioning.2021

    • Author(s)
      Takahashi S, Morimoto S, Okada K, Date Y, Ito D, Nakahara J, Okano H.
    • Organizer
      International Society for Stem Cell Research(ISSCR) Annual Meeting Germany
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Examination of αlpha-synuclein dynamics in induced pluripotent stem cell-derived dopaminergic neurons from a parkinson’s disease patient (park4) with snca triplication.2021

    • Author(s)
      Fukusumi H, Togo K, Sumida M, Nakamori M, Obika S, Baba K, Shofuda T, Ito D, Okano H, Mochizuki H, Kanemura Y.
    • Organizer
      The International Society for Stem Cell Research 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ropinirole hydrochloride identified by ipsc drug discovery for amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled phase 1/2a trial.2021

    • Author(s)
      Morimoto S, Takahashi S. Ito D. Date Y, Okada K, Chai MC, Nishiyama A, Suzuki N, Hirai M, Kabe Y, Suematsu M, Jinzaki M, Aoki M, Sato Y, Nakahara J, Suzuki N, Okano H.
    • Organizer
      The International Society for Stem Cell Research 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Utility evaluation of a tau tracer, [18F]PI-2620, in Alzheimer’s disease (ad) and non-AD tauopathies.2021

    • Author(s)
      Tezuka T, Takahata K, Seki M, Tabuchi H, Ueda R, Momota Y, Suzuki N, Morimoto A, Iwabuchi Y, Miura E, Okita H, Takao M, Kubota M, Yamamoto Y, Sano Y, Jinzaki M, Mimura M, Nakahara J, Ito D.
    • Organizer
      AD/PD 2022 International Conference on Alzheimer’s and Parkinson’s Diseases and related neurological disorders.
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] [18F]PM-PBB3 and plasma p-tau181 and NfL for Alzheimer’s disease.2021

    • Author(s)
      Tezuka T, Takahata K, Seki M, Tabuchi H, Momota Y, Bun S, Sato Y, Ueda R, Kubota M, Moriguchi S, Nakajima S, Jinzaki M, Mimura M, Nakahara J, Ito D.
    • Organizer
      第40回日本認知症学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] タウオパティーに対する疾患修飾薬の現状と展望.2021

    • Author(s)
      伊東 大介
    • Organizer
      第39回日本神経治療学会学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 尿検体を用いた、直接誘導神経の作出.2021

    • Author(s)
      前田純宏、伊東大介、武内俊樹、西村直輝、小崎健次郎、池内健、岡野栄之.
    • Organizer
      第40回日本認知症学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Evaluation of glymphatic system using diffusion MRI in AD spectrum.2021

    • Author(s)
      Kubota M, Tezuka T, Sato Y, Ueda R, Nakahara J, Ito D, Seki M
    • Organizer
      第40回日本認知症学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 聴覚失認とプロソディ障害で発症し,[18F]PM-PBB3 PETで診断に至ったtauopathyの1例.2021

    • Author(s)
      馬島恭子,小西海香,手塚俊樹,高畑圭輔,岡本康秀,関守信,田渕肇,伊東大介,中原仁,三村將.
    • Organizer
      第40回日本認知症学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] iPS 細胞創薬に基づいた筋萎縮性側索硬化症(ALS)に対するロピニロール塩酸塩の医師主導治験(ROPALS 試験)2021

    • Author(s)
      森本 悟、髙橋 愼一、伊東 大介、伊達 悠岳、岡田 健佑、Chai Muh Chyi、西山 亜由美、鈴木 直輝、平井 美和、加部 泰明、末松 誠、陣崎 雅弘、青木 正志、佐藤 泰憲、中原 仁、鈴木 則宏、岡野 栄之.
    • Organizer
      第39回日本神経治療学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Results Of A Randomized Clinical Trial of Ropinirole Hydrochloride For ALS (ROPALS) Based On iPS Cell Drug Discovery.2021

    • Author(s)
      髙橋愼一、森本悟、伊東大介、伊達悠岳、岡田健佑、Chai Muh Chyi、西山亜由美、鈴木直輝、平井美和、加部泰明、末松誠、陣崎雅弘、青木正志、佐藤泰憲、中原仁、鈴木則宏、岡野栄之.
    • Organizer
      第62回日本神経学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Remarks] 慶應義塾大学医学部神経内科

    • URL

      https://www.neurology.med.keio.ac.jp/

    • Related Report
      2021 Annual Research Report
  • [Remarks] 認知症専門外来 メモリークリニック|慶應義塾大学病院

    • URL

      https://keio-memory-clinic.com/

    • Related Report
      2021 Annual Research Report

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Published: 2021-04-28   Modified: 2024-12-25  

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