慢性心不全患者の身体活動量と身体機能の長期的管理に関する包括的研究

• Project/Area Number: 23K21594
• Project/Area Number (Other): 21H03309 (2021-2023)
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Multi-year Fund (2024); Single-year Grants (2021-2023)
• Section: 一般
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Kitasato University
• Principal Investigator: 神谷 健太郎 北里大学, 医療衛生学部, 教授 (10448970)
• Co-Investigator(Kenkyū-buntansha): 鍵山 暢之 順天堂大学, 医学部, 准教授 (20722010) ; 末永 祐哉 順天堂大学, 医学部, 准教授 (50811642) ; 宮田 裕章 慶應義塾大学, 医学部(信濃町), 教授 (70409704)
• Project Period (FY): 2021-04-01 – 2025-03-31
• Project Status: Granted (Fiscal Year 2024)
• Budget Amount: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000); Fiscal Year 2024: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2023: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2022: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2021: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
• Keywords: 身体活動量 / 身体機能 / 慢性心不全 / フレイル / 心不全 / 心血管疾患 / スマートフォン / 身体活動 / 歩行速度 / ICT / 身体渇度量 / 運動機能 / 心臓リハビリテーション

Outline of Research at the Start

継続課題のため、記入しない。

Outline of Annual Research Achievements

本研究は、以下の2つを主な目的として実施している。
①申請者らが開発した多人数身体活動量管理システムの導入が心疾患患者の身体活動量および身体機能の向上に有効であるかを多施設前向き研究により検証すること、
②スマートフォンのアプリを用いた身体活動量と歩行速度の縦断的な評価のアルゴリズムを構築し、その有用性を検証すること
①については、研究責任者の施設において実施したパイロット研究の結果についての論文が現在国際誌でリビジョン判定をうけ、修正して提出済みである。本結果に基づいて、現在多施設でRCTを展開している。急性期病院のみでなく、地域の医療機関や介護予防施設においても検証を実施している段階である。
②については、iphoneを患者に貸与してヘルスケアデータを広く収集すると共に、歩行速度や安定性などの指標をスマートフォンから収集する研究を実施しており、現在までに、200例を超える心疾患患者が書面同意のもと、研究に参加している。現在はフォローアップ期間中であるが、今後、スマートフォンから得られた指標と臨床データや予後とあわせて解析していくことにより、様々な臨床場面においてリスクの層別化や治療効果の判定に有用であるかが明らかになっていくものと考えている。
また、地域在住者に対してもアプリケーションを通じた身体活動量やフレイルデータを収集しており、上記の心不全患者のデータと突合の上、歩行速度や身体活動量、フレイルの軌跡を観察出来る様にする事を目標に進めている。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

研究目的の二つについて、計画に基づいて進捗しているため。

Strategy for Future Research Activity

今後は、①の研究については、地域在住心不全患者を含む対象者での介入研究に就いて、すでに倫理委員会承認を得ており、症例数の蓄積をすすめる。②の研究については、地域のクリニックや介護予防施設、地域在住高齢者でのリクルート継続と、経過観察をすすめ、スマートフォンデータによるフレイルや身体活動量データの妥当性、信頼性を検証していく。

Research Products

• [Journal Article] SARC-F predicts poor motor function, quality of life, and prognosis in older patients with cardiovascular disease and cognitive impairment (2023)
  • Author(s): Noda Takumi、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Yamashita Masashi、Uchida Shota、Ueno Kensuke、Maekawa Emi、Terada Tasuku、Reed Jennifer L.、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Experimental Gerontology Volume: 171 Pages: 112021-112021
  • DOI: 10.1016/j.exger.2022.112021
  • Peer Reviewed / Open Access
• [Journal Article] Association of weight change and in-hospital mortality in patients with repeated hospitalization for heart failure. (2023)
  • Author(s): Konishi M, Tamura K, Komuro I, et al.
  • Journal Title: J Cachexia Sarcopenia Muscle. Volume: 14 Issue: 1 Pages: 642-652
  • DOI: 10.1002/jcsm.13170
  • Peer Reviewed / Open Access
• [Journal Article] Protocols and Features of Goal-Setting-Based Intervention for Frail Older Adults in Community Exercise Facilities (2023)
  • Author(s): Yamashita Masashi、Mashizume Yuki、Yama Kento、Sasaki Shun、Uehara Daiki、Kamiya Kentaro
  • Journal Title: International Journal of Environmental Research and Public Health Volume: 20 Issue: 2 Pages: 1615-1615
  • DOI: 10.3390/ijerph20021615
  • Peer Reviewed / Open Access
• [Journal Article] Gait Speed and Cardiovascular Disease by Glycemic Status (2023)
  • Author(s): Ueno Kensuke、Kaneko Hidehiro、Kamiya Kentaro、Okada Akira、Suzuki Yuta、Fujiu Katsuhito、Matsuoka Satoshi、Michihata Nobuaki、Takeda Norifumi、Jo Taisuke、Morita Hiroyuki、Ako Junya、Node Koichi、Yasunaga Hideo、Komuro Issei
  • Journal Title: American Journal of Preventive Medicine Volume: - Issue: 1 Pages: 45-51
  • DOI: 10.1016/j.amepre.2022.12.012
• [Journal Article] The interaction between physical frailty and prognostic impact of heart failure medication in elderly patients (2023)
  • Author(s): Abe Takuro、Jujo Kentaro、Maeda Daichi、Saito Katsumi、Ogasahara Yuki、Saito Kazuya、Saito Hiroshi、Iwata Kentaro、Konishi Masaaki、Kitai Takeshi、Kasai Takatoshi、Wada Hiroshi、Momomura Shin‐ichi、Kagiyama Nobuyuki、Kamiya Kentaro、Yamashita Masashi、Hamazaki Nobuaki、Nozaki Kohei、Maekawa Emi、Ako Junya、Matsue Yuya
  • Journal Title: ESC Heart Failure Volume: 10 Issue: 3 Pages: 1698-1705
  • DOI: 10.1002/ehf2.14114
  • Peer Reviewed / Open Access
• [Journal Article] Association of early acute‐phase rehabilitation initiation on outcomes among patients aged ?90?years with acute heart failure (2023)
  • Author(s): Ueno Kensuke、Kaneko Hidehiro、Kamiya Kentaro、Okada Akira、Itoh Hidetaka、Konishi Masaaki、Sugimoto Tadafumi、Suzuki Yuta、Matsuoka Satoshi、Fujiu Katsuhito、Michihata Nobuaki、Jo Taisuke、Takeda Norifumi、Morita Hiroyuki、Ako Junya、Node Koichi、Yasunaga Hideo、Komuro Issei
  • Journal Title: Journal of the American Geriatrics Society Volume: - Issue: 6 Pages: 1840-1850
  • DOI: 10.1111/jgs.18283
• [Journal Article] Prognostic implications of six-minute walking distance in patients with heart failure with preserved ejection fraction (2023)
  • Author(s): Fujimoto Y、Maeda D、Kagiyama N、Sunayama T、Dotare T、Jujo K、Saito K、Kamiya K、Saito H、Ogasahara Y、Maekawa E、Konishi M、Kitai T、Iwata K、Wada H、Hiki M、Kasai T、Nagamatsu H、Ozawa T、Izawa K、Yamamoto S、Aizawa N、Wakaume K、Oka K、Momomura S、Matsue Y
  • Journal Title: International Journal of Cardiology Volume: 379 Pages: 76-81
  • DOI: 10.1016/j.ijcard.2023.03.025
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic value of liver damage assessed through direct bilirubin levels and skeletal muscle weakness in patients with heart failure (2023)
  • Author(s): Noda Takumi、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Yamashita Masashi、Uchida Shota、Maekawa Emi、Terada Tasuku、Reed Jennifer L.、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Heart & Lung Volume: 60 Pages: 87-94
  • DOI: 10.1016/j.hrtlng.2023.03.001
  • Peer Reviewed / Open Access
• [Journal Article] Prevalence and prognostic impact of the coexistence of cachexia and sarcopenia in older patients with heart failure (2023)
  • Author(s): Fujimoto Y、Maeda D、Kagiyama N、Sunayama T、Dotare T、Jujo K、Saito K、Kamiya K、Saito H、Ogasahara Y、Maekawa E、Konishi M、Kitai T、Iwata K、Wada H、Hiki M、Kasai T、Nagamatsu H、Ozawa T、Izawa K、Yamamoto S、Aizawa N、Wakaume K、Oka K、Momomura S、Matsue Y
  • Journal Title: International Journal of Cardiology Volume: 381 Pages: 45-51
  • DOI: 10.1016/j.ijcard.2023.03.035
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Quality Indicators in Patient Referral Documents for Heart Failure in Japan (2022)
  • Author(s): Yoshiharu Kinugasa, Masakazu Saitoh, Toshimi Ikegame, Aoi Ikarashi, Kazushige Kadota, Kentaro Kamiya, Shun Kohsaka, Atsushi Mizuno, Isao Miyajima, Eisaku Nakane, Azusa Nei , Tatsuhiro Shibata 11, Hiroyuki Yokoyama, Sei Yumikura, Dai Yumino, Noboru Watanabe, Mitsuaki Isobe
  • Journal Title: International Heart Journal Volume: 63 Issue: 2 Pages: 278-285
  • DOI: 10.1536/ihj.21-617
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2022-03-30
  • Peer Reviewed / Open Access
• [Journal Article] Arm lean mass measured using dual-energy X-ray absorptiometry to predict mortality in older patients with heart failure (2022)
  • Author(s): Saito Hiroshi、Matsue Yuya、Maeda Daichi、Kamiya Kentaro、Kagiyama Nobuyuki、Endo Yoshiko、Yoshioka Kenji、Mizukami Akira、Minamino Tohru
  • Journal Title: Archives of Gerontology and Geriatrics Volume: 101 Pages: 104689-104689
  • DOI: 10.1016/j.archger.2022.104689
• [Journal Article] Usefulness of measuring maximal gait speed in conjunction with usual gait speed for risk stratification in patients with cardiovascular disease (2022)
  • Author(s): Ueno Kensuke、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Yamashita Masashi、Uchida Shota、Noda Takumi、Maekawa Emi、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Experimental Gerontology Volume: 164 Pages: 111810-111810
  • DOI: 10.1016/j.exger.2022.111810
  • Peer Reviewed / Open Access
• [Journal Article] Clinical utility of simple subjective gait speed for the risk stratification of heart failure in a primary prevention setting (2022)
  • Author(s): Ueno Kensuke、Kaneko Hidehiro、Kamiya Kentaro、Itoh Hidetaka、Okada Akira、Suzuki Yuta、Matsuoka Satoshi、Fujiu Katsuhito、Michihata Nobuaki、Jo Taisuke、Takeda Norifumi、Morita Hiroyuki、Ako Junya、Yasunaga Hideo、Komuro Issei
  • Journal Title: Scientific Reports Volume: 12 Issue: 1
  • DOI: 10.1038/s41598-022-13752-7
• [Journal Article] Associations between dynapenia, cardiovascular hospitalizations, and all‐cause mortality among patients on haemodialysis (2022)
  • Author(s): Yoshikoshi Shun、Yamamoto Shohei、Suzuki Yuta、Imamura Keigo、Harada Manae、Osada Shiwori、Kamiya Kentaro、Matsunaga Atsuhiko
  • Journal Title: Journal of Cachexia, Sarcopenia and Muscle Volume: 13 Issue: 5 Pages: 2417-2425
  • DOI: 10.1002/jcsm.13039
  • Peer Reviewed / Open Access
• [Journal Article] Sex Differences in Frequency of Instrumental Activities of Daily Living after Cardiac Rehabilitation and Its Impact on Outcomes in Patients with Heart Failure (2022)
  • Author(s): Nozaki Kohei、Hamazaki Nobuaki、Kamiya Kentaro、Kariya Hidenori、Uchida Shota、Noda Takumi、Ueno Kensuke、Maekawa Emi、Matsunaga Atsuhiko、Yamaoka-Tojo Minako、Ako Junya
  • Journal Title: Journal of Cardiovascular Development and Disease Volume: 9 Issue: 9 Pages: 289-289
  • DOI: 10.3390/jcdd9090289
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Utility of the Fatigue, Resistance, Ambulation, Illness, and Loss of weight Scale in Older Patients with Cardiovascular Disease (2022)
  • Author(s): Yamato Yohei、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Yamashita Masashi、Uchida Shota、Noda Takumi、Maekawa Emi、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Journal of the American Medical Directors Association Volume: 23 Issue: 12 Pages: 1971-1976.e2
  • DOI: 10.1016/j.jamda.2022.08.006
  • Peer Reviewed
• [Journal Article] Association between SGLT2 Inhibitors and Cardiac Rehabilitation Outcomes in Patients with Cardiovascular Disease and Type 2 Diabetes Mellitus (2022)
  • Author(s): Kashima Ayuko、Kamiya Kentaro、Hamazaki Nobuaki、Ueno Kensuke、Nozaki Kohei、Ichikawa Takafumi、Yamashita Masashi、Uchida Shota、Noda Takumi、Hotta Kazuki、Maekawa Emi、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Journal of Clinical Medicine Volume: 11 Issue: 19 Pages: 5956-5956
  • DOI: 10.3390/jcm11195956
• [Journal Article] Effects of a multidisciplinary intervention to promote physical activity in patients with stroke undergoing rehabilitation: study protocol for the ActivePAS pilot randomised controlled trial (2022)
  • Author(s): Kanai Masashi、Nozoe Masafumi、Ohtsubo Takuro、Ueno Katsuhiro、Nakayama Mai、Yamashita Masashi、Kamiya Kentaro
  • Journal Title: BMJ Open Sport and Exercise Medicine Volume: 8 Issue: 4 Pages: e001401-e001401
  • DOI: 10.1136/bmjsem-2022-001401
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between the spread of COVID-19, social frailty, and depressive symptoms in patients with heart failure (2022)
  • Author(s): Shakuta Saki、Yamashita Masashi、Kamiya Kentaro、Hamazaki Nobuaki、Ueno Kensuke、Nozaki Kohei、Uchida Shota、Noda Takumi、Maekawa Emi、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Heart and Vessels Volume: - Issue: 7 Pages: 992-996
  • DOI: 10.1007/s00380-022-02203-y
  • Peer Reviewed
• [Journal Article] Overlapping states of AWGS muscle dysfunction and inverse feasibility of ADL recovery by rehabilitation in older inpatients (2022)
  • Author(s): Yamashita Masashi、Obata Hiroaki、Kamiya Kentaro、Matsunaga Atsuhiko、Hotta Kazuki、Izumi Tohru
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 22283-22283
  • DOI: 10.1038/s41598-022-26622-z
• [Journal Article] 【避けて通れない心不全診療-総合内科力・循環器力を鍛えよう!】慢性心不全 心不全のリハビリテーションについて教えてください(解説) (2022)
  • Author(s): 神谷健太郎
  • Journal Title: Medicina Volume: 59 Pages: 2230-2235
• [Journal Article] Inaccurate recognition of own comorbidities is associated with poor prognosis in elderly patients with heart failure (2022)
  • Author(s): Maeda Daichi、Matsue Yuya、et al.
  • Journal Title: ESC Heart Failure Volume: 9 Issue: 2 Pages: 1351-1359
  • DOI: 10.1002/ehf2.13824
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Risk for Proteinuria in Newly Defined Hypertensive People Based on the 2017 American College of Cardiology/American Heart Association Blood Pressure Guideline (2022)
  • Author(s): Suzuki Yuta、Kaneko Hidehiro、Okada Akira、Itoh Hidetaka、Fujiu Katsuhito、Michihata Nobuaki、Jo Taisuke、Takeda Norifumi、Morita Hiroyuki、Yamaguchi Satoko、Yano Yuichiro、Kamiya Kentaro、et al.
  • Journal Title: The American Journal of Cardiology Volume: 168 Pages: 83-89
  • DOI: 10.1016/j.amjcard.2021.12.023
  • Peer Reviewed
• [Journal Article] Impact of Preoperative Muscle Strength on Walking Independence After Total Hip Arthroplasty (2022)
  • Author(s): Nozaki Kohei、Nanri Yuta、Yamamoto Shohei、Hamazaki Nobuaki、Noda Takumi、Yamashita Masashi、Shirota Takehiro、Uchiyama Katsufumi、Fukushima Kensuke、Kamiya Kentaro、Takahira Naonobu、Takaso Masashi
  • Journal Title: Journal of the American Medical Directors Association Volume: 23 Issue: 4 Pages: 695-697
  • DOI: 10.1016/j.jamda.2021.11.006
  • Peer Reviewed
• [Journal Article] Efficacy and Safety of Acute Phase Intensive Electrical Muscle Stimulation in Frail Older Patients with Acute Heart Failure: Results from the ACTIVE-EMS Trial (2022)
  • Author(s): Tanaka Shinya、Kamiya Kentaro、Matsue Yuya、Yonezawa Ryusuke、Saito Hiroshi、Hamazaki Nobuaki、Matsuzawa Ryota、Nozaki Kohei、Yamashita Masashi、Wakaume Kazuki、Endo Yoshiko、Maekawa Emi、Yamaoka-Tojo Minako、Shiono Takaaki、Inomata Takayuki、Ako Junya
  • Journal Title: Journal of Cardiovascular Development and Disease Volume: 9 Issue: 4 Pages: 99-99
  • DOI: 10.3390/jcdd9040099
  • Peer Reviewed / Open Access
• [Journal Article] The Prevalence of Metabolic Dysfunction-Associated Fatty Liver Disease and Its Association with Physical Function and Prognosis in Patients with Acute Coronary Syndrome (2022)
  • Author(s): Noda Takumi、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Yamashita Masashi、Uchida Shota、Maekawa Emi、Terada Tasuku、Reed Jennifer L.、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Journal of Clinical Medicine Volume: 11 Issue: 7 Pages: 1847-1847
  • DOI: 10.3390/jcm11071847
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Acute-Phase Initiation of Cardiac Rehabilitation for Short-Term Improvement in Activities of Daily Living in Patients Hospitalized for Acute Heart Failure (2022)
  • Author(s): Ueno Kensuke、Kamiya Kentaro、Kaneko Hidehiro、Okada Akira、Itoh Hidetaka、Fujiu Katsuhito、Takeda Norifumi、Morita Hiroyuki、Michihata Nobuaki、Jo Taisuke、Yasunaga Hideo、Komuro Issei
  • Journal Title: Journal of Cardiovascular Development and Disease Volume: 9 Issue: 4 Pages: 97-97
  • DOI: 10.3390/jcdd9040097
  • Peer Reviewed / Open Access
• [Journal Article] Sex-specific associations of fat mass and muscle mass with cardiovascular disease risk factors in adults with type 2 diabetes living with overweight and obesity: secondary analysis of the Look AHEAD trial (2022)
  • Author(s): Terada Tasuku、Reed Jennifer L.、Vidal-Almela Sol、Mistura Matheus、Kamiya Kentaro、Way Kimberley L.
  • Journal Title: Cardiovascular Diabetology Volume: 21 Issue: 1
  • DOI: 10.1186/s12933-022-01468-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of Glucose Tolerance and Its Change on Incident Proteinuria: Analysis of a Nationwide Population-Based Dataset (2022)
  • Author(s): Suzuki Yuta、Kaneko Hidehiro、Okada Akira、Itoh Hidetaka、Fujiu Katsuhito、Michihata Nobuaki、Jo Taisuke、Takeda Norifumi、Morita Hiroyuki、Yamaguchi Satoko、Kamiya Kentaro、Matsunaga Atsuhiko、Ako Junya、Node Koichi、Yamauchi Toshimasa、Nangaku Masaomi、Yasunaga Hideo、Komuro Issei
  • Journal Title: American Journal of Nephrology Volume: - Issue: 4 Pages: 1-9
  • DOI: 10.1159/000522280
  • Peer Reviewed
• [Journal Article] Correlation between respiratory muscle weakness and frailty status as risk markers for poor outcomes in patients with cardiovascular disease (2022)
  • Author(s): Hamazaki Nobuaki、Kamiya Kentaro、Nozaki Kohei、Yamashita Masashi、Uchida Shota、Noda Takumi、Maekawa Emi、Meguro Kentaro、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: European Journal of Cardiovascular Nursing Volume: in press Issue: 8 Pages: 782-790
  • DOI: 10.1093/eurjcn/zvac014
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Work status before admission relates to prognosis in older patients with heart failure partly through social frailty (2022)
  • Author(s): Yamashita Masashi、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、et al.
  • Journal Title: Journal of Cardiology Volume: 79 Issue: 3 Pages: 439-445
  • DOI: 10.1016/j.jjcc.2021.10.029
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comparison of the association between six different frailty scales and clinical events in patients on hemodialysis (2022)
  • Author(s): Imamura Keigo、Yamamoto Shohei、Suzuki Yuta、Yoshikoshi Shun、Harada Manae、Osada Shiwori、Kamiya Kentaro、Matsuzawa Ryota、Matsunaga Atsuhiko
  • Journal Title: Nephrology Dialysis Transplantation Volume: - Issue: 2 Pages: 455-462
  • DOI: 10.1093/ndt/gfac047
  • Peer Reviewed
• [Journal Article] Prognostic value of postural hypotension in hospitalized patients with heart failure (2022)
  • Author(s): Sunayama Tsutomu、Maeda Daichi、Matsue Yuya、Kagiyama Nobuyuki、Jujo Kentaro、Saito Kazuya、Kamiya Kentaro、et al.
  • Journal Title: Scientific Reports Volume: 12 Issue: 1
  • DOI: 10.1038/s41598-022-06760-0
  • Peer Reviewed / Open Access
• [Journal Article] Effects of electrical muscle stimulation on physical function in frail older patients with acute heart failure: a randomized controlled trial (2022)
  • Author(s): Tanaka Shinya、Kamiya Kentaro、Matsue Yuya、Yonezawa Ryusuke、Saito Hiroshi、Hamazaki Nobuaki、Matsuzawa Ryota、Nozaki Kohei、Yamashita Masashi、Wakaume Kazuki、Endo Yoshiko、Maekawa Emi、Yamaoka-Tojo Minako、Shiono Takaaki、Inomata Takayuki、Ako Junya
  • Journal Title: European Journal of Preventive Cardiology Volume: in press Issue: 8 Pages: e286-e288
  • DOI: 10.1093/eurjpc/zwac022
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Sex differences in the prevalence and prognostic impact of physical frailty and sarcopenia among older patients with heart failure (2022)
  • Author(s): Maeda Daichi、Matsue Yuya、Kagiyama Nobuyuki、Jujo Kentaro、Saito Kazuya、Kamiya Kentaro、Saito Hiroshi、Ogasahara Yuki、Maekawa Emi、Konishi Masaaki、Kitai Takeshi、Iwata Kentaro、Wada Hiroshi、Hiki Masaru、Dotare Taishi、Sunayama Tsutomu、Kasai Takatoshi、Nagamatsu Hirofumi、Ozawa Tetsuya、Izawa Katsuya、et al.
  • Journal Title: Nutrition, Metabolism and Cardiovascular Diseases Volume: 32 Issue: 2 Pages: 365-372
  • DOI: 10.1016/j.numecd.2021.10.012
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Physical activity and its trajectory over time and clinical outcomes in hemodialysis patients (2022)
  • Author(s): Suzuki Yuta、Matsuzawa Ryota、Hoshi Keika、Koh Yong Mo、Harada Manae、Yamamoto Shohei、Imamura Keigo、Kamiya Kentaro、Matsunaga Atsuhiko
  • Journal Title: International Urology and Nephrology Volume: 54 Issue: 8 Pages: 2065-2074
  • DOI: 10.1007/s11255-021-03098-w
  • Peer Reviewed
• [Journal Article] Change in Cardiovascular Health Metrics and Risk for Proteinuria Development: Analysis of a Nationwide Population-Based Database (2022)
  • Author(s): Suzuki Yuta、Kaneko Hidehiro、Okada Akira、Itoh Hidetaka、Morita Kojiro、Fujiu Katsuhito、Michihata Nobuaki、Jo Taisuke、Takeda Norifumi、Morita Hiroyuki、Yamaguchi Satoko、Kamiya Kentaro、et al.
  • Journal Title: American Journal of Nephrology Volume: 53 Issue: 2-3 Pages: 240-248
  • DOI: 10.1159/000522147
  • Peer Reviewed
• [Journal Article] Gait speed and 6-minute walking distance are useful for identifying difficulties in activities of daily living in patients with cardiovascular disease (2022)
  • Author(s): Sato Ayaka、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Yamashita Masashi、Uchida Shota、Maekawa Emi、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Heart & Lung Volume: 51 Pages: 46-51
  • DOI: 10.1016/j.hrtlng.2021.09.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Differences in Priorities for Heart Failure Management Between Cardiologists and General Practitioners in Japan (2021)
  • Author(s): Kinugasa Y, Saitoh M, Ikegame T, Ikarashi A, Kadota K, Kamiya K, Kohsaka S, Mizuno A, Miyajima I, Nakane E, Nei A, Shibata T, Yokoyama H, Yumikura S, Yumino D, Watanabe N, Isobe M; Research Team for the Provision of Heart Failure Care Centered on General Practitioners in the Community.
  • Journal Title: Circulation Journal Volume: 85 Issue: 9 Pages: 1565-1574
  • DOI: 10.1253/circj.CJ-21-0335
  • NAID: 130008077944
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2021-08-25
  • Peer Reviewed / Open Access
• [Journal Article] Usefulness of physical function sub-item of SF-36 survey to predict exercise intolerance in patients with heart failure (2021)
  • Author(s): Ueno Kensuke、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Yamashita Masashi、Uchida Shota、Kawabata Masashi、Maekawa Emi、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: European Journal of Cardiovascular Nursing Volume: 21 Issue: 2 Pages: 174-177
  • DOI: 10.1093/eurjcn/zvab052
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Associations between kidney function and outcomes of comprehensive cardiac rehabilitation in patients with heart failure (2021)
  • Author(s): Hamazaki Nobuaki、Kamiya Kentaro、Yamamoto Shohei、Nozaki Kohei、Ichikawa Takafumi、Matsuzawa Ryota、Yamashita Masashi、Uchida Shota、Maekawa Emi、Meguro Kentaro、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Clinical Research in Cardiology Volume: 111 Issue: 3 Pages: 253-263
  • DOI: 10.1007/s00392-021-01875-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sex and Age Differences in Anxiety and Depression Levels Before and After Aerobic Interval Training in Cardiac Rehabilitation (2021)
  • Author(s): O'Neill Carley D.、Vidal-Almela Sol、Terada Tasuku、Kamiya Kentaro、Tulloch Heather E.、Pipe Andrew L.、Reed Jennifer L.
  • Journal Title: Journal of Cardiopulmonary Rehabilitation and Prevention Volume: 42 Issue: 1 Pages: 15-21
  • DOI: 10.1097/hcr.0000000000000617
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] New Formula to Predict Heart Rate at Anaerobic Threshold That Considers the Effects of β-Blockers in Patients With Myocardial Infarction (2021)
  • Author(s): Nemoto Shinji、Kasahara Yusuke、Izawa Kazuhiro P.、Watanabe Satoshi、Yoshizawa Kazuya、Takeichi Naoya、Kamiya Kentaro、Suzuki Norio、Omiya Kazuto、Kida Keisuke、Matsunaga Atsuhiko、Akashi Yoshihiro J.
  • Journal Title: Journal of Cardiopulmonary Rehabilitation and Prevention Volume: 42 Issue: 1 Pages: E1-E6
  • DOI: 10.1097/hcr.0000000000000602
  • Peer Reviewed
• [Journal Article] Impact of physical performance on exercise capacity in older patients with heart failure with reduced and preserved ejection fraction (2021)
  • Author(s): Saka Kenichiro、Konishi Masaaki、Kagiyama Nobuyuki、Kamiya Kentaro、Saito Hiroshi、Saito Kazuya、Ogasahara Yuki、Maekawa Emi、Misumi Toshihiro、Kitai Takeshi、Iwata Kentaro、Jujo Kentaro、Wada Hiroshi、Kasai Takatoshi、Nagamatsu Hirofumi、Ozawa Tetsuya、Izawa Katsuya、Yamamoto Shuhei、Aizawa Naoki、et al.
  • Journal Title: Experimental Gerontology Volume: 156 Pages: 111626-111626
  • DOI: 10.1016/j.exger.2021.111626
  • Peer Reviewed
• [Journal Article] Moving Together While Staying Apart: Practical Recommendations for 24-Hour Home-Based Movement Behaviours for Those With Cardiovascular Disease (2021)
  • Author(s): O’Neill Carley D.、Vidal-Almela Sol、Terada Tasuku、Way Kimberley L.、Kamiya Kentaro、Sperlich Billy、Duking Peter、Chaput Jean-Phillipe、Prince Stephanie A.、Pipe Andrew L.、Reed Jennifer L.
  • Journal Title: CJC Open Volume: 3 Issue: 12 Pages: 1495-1504
  • DOI: 10.1016/j.cjco.2021.08.010
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of atrial fibrillation on response to exercise-based cardiac rehabilitation in older individuals with heart failure (2021)
  • Author(s): Nobuaki Hamazaki, Kentaro Kamiya, Hidehira Fukaya, Kohei Nozaki, Takafumi Ichikawa, Ryota Matsuzawa, Masashi Yamashita, Shota Uchida, Emi Maekawa, Kentaro Meguro, Minako Yamaoka-Tojo, Atsuhiko Matsunaga, Junya Ako
  • Journal Title: Annals of Physical and Rehabilitation Medicine Volume: - Issue: 6 Pages: 101466-101466
  • DOI: 10.1016/j.rehab.2020.101466
  • Peer Reviewed
• [Journal Article] Acute-phase initiation of cardiac rehabilitation and clinical outcomes in hospitalized patients for acute heart failure (2021)
  • Author(s): Kaneko Hidehiro、Itoh Hidetaka、Kamiya Kentaro、Morita Kojiro、Sugimoto Tadafumi、Konishi Masaaki、Kiriyama Hiroyuki、Kamon Tatsuya、Fujiu Katsuhito、Michihata Nobuaki、Jo Taisuke、Takeda Norifumi、Morita Hiroyuki、Yasunaga Hideo、Komuro Issei
  • Journal Title: International Journal of Cardiology Volume: 340 Pages: 36-41
  • DOI: 10.1016/j.ijcard.2021.08.041
  • Peer Reviewed
• [Journal Article] Standardized gait speed ratio in elderly patients with heart failure (2021)
  • Author(s): Ozawa Tetsuya、Matsue Yuya et al.
  • Journal Title: ESC Heart Failure Volume: 8 Issue: 5 Pages: 3557-3565
  • DOI: 10.1002/ehf2.13392
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of Social Frailty in Hospitalized Elderly Patients With Heart Failure: A FRAGILE‐HF Registry Subanalysis (2021)
  • Author(s): Jujo Kentaro、Matsue Yuya、et al.
  • Journal Title: Journal of the American Heart Association Volume: 10 Issue: 17
  • DOI: 10.1161/jaha.120.019954
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of Sarcopenia in the Intensive Care Unit and 1-Year Mortality in Survivors of Critical Illness (2021)
  • Author(s): Yanagi Naoya、Koike Tomotaka、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Matsunaga Atsuhiko、Kuroiwa Masayuki、Arai Masayasu
  • Journal Title: Nutrients Volume: 13 Issue: 8 Pages: 2726-2726
  • DOI: 10.3390/nu13082726
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Validity and Utility of the Questionnaire-based FRAIL Scale in Older Patients with Heart Failure: Findings from the FRAGILE-HF (2021)
  • Author(s): Nozaki K, Kamiya K, Hamazaki N, Saito H, Saito K, Ogasahara Y, Maekawa E, Konishi M, Kitai T, Iwata K, Jujo K, Wada H, Kasai T, Nagamatsu H, Ozawa T, Izawa K, Yamamoto S, Aizawa N, Makino A, Oka K, Momomura SI, Kagiyama N, Matsue Y.
  • Journal Title: J Am Med Dir Assoc Volume: － Issue: 8 Pages: 1621-1626.e2
  • DOI: 10.1016/j.jamda.2021.02.025
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Clinical usefulness of oxygen uptake during usual gait in patients with cardiovascular disease (2021)
  • Author(s): Hamazaki Nobuaki、Kamiya Kentaro、Nozaki Kohei、Yanagi Naoya、Ichikawa Takafumi、Matsuzawa Ryota、Nakamura Takeshi、Yamashita Masashi、Uchida Shota、Saito Teppei、Maekawa Emi、Meguro Kentaro、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: International Journal of Cardiology Volume: 335 Pages: 118-122
  • DOI: 10.1016/j.ijcard.2021.04.049
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Aspartate aminotransferase to alanine aminotransferase ratio is associated with frailty and mortality in older patients with heart failure (2021)
  • Author(s): Maeda Daichi、Matsue Yuya、et al.
  • Journal Title: Scientific Reports Volume: 11 Issue: 1
  • DOI: 10.1038/s41598-021-91368-z
  • Peer Reviewed / Open Access
• [Journal Article] Low skeletal muscle density combined with muscle dysfunction predicts adverse events after adult cardiovascular surgery (2021)
  • Author(s): Yamashita M, Kamiya K, Matsunaga A, Kitamura T, Hamazaki N, Nozaki K, Ichikawa T, Maekawa E, Meguro K, Yamaoka-Tojo M, Ako J, Miyaji K.
  • Journal Title: Nutr Metab Cardiovasc Dis Volume: － Issue: 6 Pages: 1782-1790
  • DOI: 10.1016/j.numecd.2021.02.012
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Correction to: Multidomain Frailty in Heart Failure: Current Status and Future Perspectives (2021)
  • Author(s): Tanaka Shinya、Yamashita Masashi、Saito Hiroshi、Kamiya Kentaro、Maeda Daichi、Konishi Masaaki、Matsue Yuya
  • Journal Title: Current Heart Failure Reports Volume: - Issue: 3 Pages: 121-121
  • DOI: 10.1007/s11897-021-00516-z
  • Peer Reviewed
• [Journal Article] Impact of Physical Activity on Dialysis and Nondialysis Days and Clinical Outcomes Among Patients on Hemodialysis. (2020)
  • Author(s): Yamamoto S, Matsuzawa R, Hoshi K, Harada M, Watanabe T, Suzuki Y, Isobe Y, Imamura K, Osada S, Yoshida A, Kamiya K, Matsunaga A
  • Journal Title: J Ren Nutr Volume: - Issue: 4 Pages: 380-388
  • DOI: 10.1053/j.jrn.2020.07.007
  • Peer Reviewed / Open Access
• [Journal Article] Modified Creatinine Index and Clinical Outcomes of Hemodialysis Patients: An Indicator of Sarcopenia? (2020)
  • Author(s): Yamamoto S, Matsuzawa R, Hoshi K, Suzuki Y, Harada M, Watanabe T, Isobe Y, Imamura K, Osada S, Yoshida A, Kamiya K, Matsunaga A
  • Journal Title: J Ren Nutr Volume: - Issue: 4 Pages: 370-379
  • DOI: 10.1053/j.jrn.2020.08.006
  • Peer Reviewed / Open Access
• [Presentation] 地域在住高齢者におけるスマートフォンを用いた歩行速度の測定に関する傾向 (2022)
  • Author(s): 山下真司，神谷健太郎，堀田一樹，窪田杏奈，橋田浩一，宮田裕章
  • Organizer: 第9回日本サルコペニア・フレイル学会
• [Presentation] 心不全に対する心臓リハビリテーション (2022)
  • Author(s): 神谷健太郎
  • Organizer: 第59回日本リハビリテーション医学会
  • Invited
• [Presentation] Prognostic value of liver damage assessed by direct bilirubin and skeletal muscle weakness in patients with heart failure (2022)
  • Author(s): Takumi Noda, Kentaro Kamiya, Nobuaki Hamazaki, Kohei Nozaki, Takafumi Ichikawa, Masashi Yamashita, Shota Uchida, Emi Maekawa, Minako Yamaoka-Tojo, Atsuhiko Matsunaga, Junya Ako
  • Organizer: ESC Congress 2022
  • Int'l Joint Research
• [Presentation] Clinical impact of improving sarcopenia through cardiac rehabilitation in patients with heart failure (2022)
  • Author(s): Shakuta Saki, Takumi Noda, Kentaro Kamiya, Nobuaki Hamazaki, Kohei Nozaki, Takafumi Ichikawa, Masashi Yamashita, Shota Uchida, Emi Maekawa, Minako Yamaoka-Tojo, Atsuhiko Matsunaga, Junya Ako
  • Organizer: ESC Congress 2022
  • Int'l Joint Research
• [Presentation] Impact of small-airway disease on exercise intolerance and long-term outcomes in patients with heart failure and reduced or preserved ejection fraction (2022)
  • Author(s): Daina Nagumo, Nobuaki Hamazaki, Kentaro Kamiya, Kohei Nozaki, Takafumi Ichikawa, Masashi Yamashita, Shota Uchida, Emi Maekawa, Minako Yamaoka-Tojo, Atsuhiko Matsunaga, Junya Ako
  • Organizer: ESC Congress 2022
  • Int'l Joint Research
• [Presentation] Cancer as a risk factor for physical dysfunction and poor prognosis in patients with cardiovascular disease. (2022)
  • Author(s): Takashi Miki, Kentaro Kamiya, Nobuaki Hamazaki, Kohei Nozaki, Takafumi Ichikawa, Masashi Yamashita, Shota Uchida, Emi Maekawa, Minako Yamaoka-Tojo, Atsuhiko Matsunaga, Junya Ako
  • Organizer: ESC Congress 2022
  • Int'l Joint Research
• [Presentation] DPC,レセプトデータを用いたビッグデータの活用 (2022)
  • Author(s): 神谷健太郎
  • Organizer: 第6回日本循環器理学療法学会
  • Invited
• [Presentation] フレイルの早期検知に向けたデジタル領域からの取り組み (2022)
  • Author(s): 神谷健太郎
  • Organizer: 第1回日本老年療法学会
  • Invited