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Social seeking, preference and maintenance in autistic people: Molecular mechanism, social adaptation and development

Research Project

Project/Area Number 23K22373
Project/Area Number (Other) 22H01102 (2022-2023)
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeMulti-year Fund (2024)
Single-year Grants (2022-2023)
Section一般
Review Section Basic Section 10040:Experimental psychology-related
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

Senju Atsushi  浜松医科大学, 子どものこころの発達研究センター, 教授 (00557738)

Co-Investigator(Kenkyū-buntansha) 福田 冬季子  浜松医科大学, 医学部, 特任教授 (10458268)
尾内 康臣  浜松医科大学, 光医学総合研究所, 教授 (40436978)
山末 英典  浜松医科大学, 医学部, 教授 (80436493)
Project Period (FY) 2024-04-01 – 2025-03-31
Project Status Completed (Fiscal Year 2024)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2024: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2023: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2022: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords自閉スペクトラム症 / 社会的認知 / 社会行動 / 発達 / ASD / 社会性 / 自閉症 / 社会的動機付け / 認知発達 / 動機付け / 脳機能イメージング / 視線計測
Outline of Research at the Start

本研究では、社会的動機付けの基盤となる認知機構である(1)社会的探究・嗜好、及び(2)社会関係の維持、の2者について、まず定型発達及びASD成人を対象としたPET(ドパミン系)および1H-MRS(グルタミン酸、GABA)計測による分子機序、fMRIと行動計測による脳神経基盤・認知基盤、さらに実験参加者の質問紙への回答の定量的分析や発話記録による主観経験についての質的分析を行う(研究1)。並行して、児童・思春期(10-16歳)の定型発達児、ASD児を対象として、(1)社会的探究・嗜好、及び(2)社会関係の維持、のそれぞれについての横断的な発達研究を行う(研究2)。

Outline of Final Research Achievements

We developed a series of research methods to quantify social motivation and more general motivation, which helped us identify motivational characteristics of autistic people. We also conducted a series of questionnaire surveys and interview studies on the subjective experiences of social environment in autistic people, which helped us identify the strategies that autistic people use to adapt to the social environment, their subjective experiences regarding these strategies, and even examples of difficulties in adapting. In addition, we reported preliminary results on the molecular mechanisms behind these social and general motivations, enabling the development of future research.

Academic Significance and Societal Importance of the Research Achievements

自閉スペクトラム当事者の社会適応の困難さの背景には、社会的動機付けの困難さがあると議論されている。本研究では、この議論に理論的・実証的な貢献を行うため、一連の実験研究・調査研究・理論研究を行なった。これらの結果からは、自閉スペクトラム当事者が社会参画を希望するものの、現実社会の様々な側面において困難さを抱えることが確認された。

Report

(4 results)
  • 2024 Annual Research Report   Final Research Report ( PDF )
  • 2023 Annual Research Report
  • 2022 Annual Research Report
  • Research Products

    (23 results)

All 2025 2024 2023 2022 Other

All Int'l Joint Research (6 results) Journal Article (17 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 17 results,  Open Access: 16 results)

  • [Int'l Joint Research] ユトレヒト大学(オランダ)

    • Related Report
      2024 Annual Research Report
  • [Int'l Joint Research] ロンドン芸術大学(英国)

    • Related Report
      2024 Annual Research Report
  • [Int'l Joint Research] マギル大学(カナダ)

    • Related Report
      2024 Annual Research Report
  • [Int'l Joint Research] Birkbeck, University of London/University of East London(英国)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Utrecht University(オランダ)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] McGill University(カナダ)

    • Related Report
      2022 Annual Research Report
  • [Journal Article] The preference for surprise in reinforcement learning underlies the differences in developmental changes in risk preference between autistic and neurotypical youth2025

    • Author(s)
      Sumiya, M., Katahira, K., Akechi, H., & Senju, A.
    • Journal Title

      Molecular Autism

      Volume: 16 Issue: 1 Pages: 3-3

    • DOI

      10.1186/s13229-025-00637-5

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Camouflaging in Autistic Adults is Modulated by Autistic and Neurotypical Characteristics of Interaction Partners2024

    • Author(s)
      Funawatari Ren、Sumiya Motofumi、Iwabuchi Toshiki、Nishimura Tomoko、Komeda Hidetsugu、Senju Atsushi
    • Journal Title

      Journal of Autism and Developmental Disorders

      Volume: - Issue: 10 Pages: 1-11

    • DOI

      10.1007/s10803-024-06481-5

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Double-Edged Effects of Social Strategies on the Well-Being of Autistic People: Impact of Self-Perceived Effort and Efficacy2024

    • Author(s)
      Funawatari Ren、Sumiya Motofumi、Iwabuchi Toshiki、Senju Atsushi
    • Journal Title

      Brain Sciences

      Volume: 14 Issue: 10 Pages: 962-962

    • DOI

      10.3390/brainsci14100962

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gaze-action coupling, gaze-gesture coupling, and exogenous attraction of gaze in dyadic interactions2024

    • Author(s)
      Hessels Roy S.、Li Peitong、Balali Sofia、Teunisse Martin K.、Poppe Ronald、Niehorster Diederick C.、Nystr?m Marcus、Benjamins Jeroen S.、Senju Atsushi、Salah Albert A.、Hooge Ignace T. C.
    • Journal Title

      Attention, Perception, & Psychophysics

      Volume: 86 Issue: 8 Pages: 2761-2777

    • DOI

      10.3758/s13414-024-02978-4

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fine Motor Skills, a Surrogate of Motor Planning Ability, at Age 2 Predict Social Skills at Age 62024

    • Author(s)
      Goto Satoko、Nishimura Tomoko、Okumura Akemi、Harada Taeko、Rahman Mohammad Shafiur、Iwabuchi Toshiki、Sumiya Motofumi、Senju Atsushi、Tsuchiya Kenji J.
    • Journal Title

      Journal of Developmental & Behavioral Pediatrics

      Volume: 45 Issue: 2 Pages: e168-e175

    • DOI

      10.1097/dbp.0000000000001258

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Brief Reports: Influence of Friendship on Loneliness Among Adolescents with Autism Spectrum Disorders in Japan2023

    • Author(s)
      Sumiya Motofumi、Senju Atsushi
    • Journal Title

      Journal of Autism and Developmental Disorders

      Volume: Online Issue: 4 Pages: 1-7

    • DOI

      10.1007/s10803-023-05958-z

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Task-related gaze behaviour in face-to-face dyadic collaboration: Toward an interactive theory?2023

    • Author(s)
      Hessels Roy S.、Teunisse Martin K.、Niehorster Diederick C.、Nystrom Marcus、Benjamins Jeroen S.、Senju Atsushi、Hooge Ignace T. C.
    • Journal Title

      Visual Cognition

      Volume: 31 Issue: 4 Pages: 291-313

    • DOI

      10.1080/13506285.2023.2250507

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The audience who knew too much: investigating the role of spontaneous theory of mind on the processing of dramatic irony scenes in film2023

    • Author(s)
      Cabanas Cynthia、Senju Atsushi、Smith Tim J.
    • Journal Title

      Frontiers in Psychology

      Volume: 14

    • DOI

      10.3389/fpsyg.2023.1183660

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cognitive Impact of Social Virtual Reality: Audience and Mere Presence Effect of Virtual Companions2023

    • Author(s)
      Sutskova Olga、Senju Atsushi、Smith Tim J.
    • Journal Title

      Human Behavior and Emerging Technologies

      Volume: 2023 Pages: 1-19

    • DOI

      10.1155/2023/6677789

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lower Availability of Mitochondrial Complex I in Anterior Cingulate Cortex in Autism: A Positron Emission Tomography Study2023

    • Author(s)
      Kato Yasuhiko、Yokokura Masamichi、Iwabuchi Toshiki、Murayama Chihiro、Harada Taeko、Goto Takafumi、Tamayama Taishi、Kameno Yosuke、Wakuda Tomoyasu、Kuwabara Hitoshi、Benner Seico、Senju Atsushi、Tsukada Hideo、Nishizawa Sadahiko、Ouchi Yasuomi、Yamasue Hidenori
    • Journal Title

      American Journal of Psychiatry

      Volume: 180 Issue: 4 Pages: 277-284

    • DOI

      10.1176/appi.ajp.22010014

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sex differences in neurodevelopmental trajectories in children with different levels of autistic traits2023

    • Author(s)
      Nishimura Tomoko、Takahashi Nagahide、Okumura Akemi、Harada Taeko、Iwabuchi Toshiki、Nakayasu Chikako、Rahman Mohammad Shafiur、Uchiyama Satoshi、Wakuta Manabu、Nomura Yoko、Takei Nori、Senju Atsushi、Tsuchiya Kenji J.
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: - Issue: 5 Pages: 282-289

    • DOI

      10.1111/pcn.13529

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Action value calculations in social context from infancy2023

    • Author(s)
      Ishikawa Mitsuhiko、Senju Atsushi
    • Journal Title

      Trends in Cognitive Sciences

      Volume: 27 Issue: 3 Pages: 227-229

    • DOI

      10.1016/j.tics.2022.12.005

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Socioeconomic and education-based inequality in suspected developmental delays among Nepalese children: a subnational level assessment2023

    • Author(s)
      Acharya Kiran, Rahman Md. Shafiur, Islam Md. Rashedul, Gilmour Stuart, Dhungel Bibha, Parajuli Rajendra P, Nishimura Tomoko, Senju Atsushi, Tsuchiya Kenji J.
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 4750-4750

    • DOI

      10.1038/s41598-023-31629-1

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Physiological arousal explains infant gaze following in various social contexts2022

    • Author(s)
      Ishikawa Mitsuhiko、Senju Atsushi、Kato Masaharu、Itakura Shoji
    • Journal Title

      Royal Society Open Science

      Volume: 9 Issue: 8 Pages: 220592-220592

    • DOI

      10.1098/rsos.220592

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neural mechanisms underlying rule selection based on response evaluation: a near-infrared spectroscopy study2022

    • Author(s)
      Harada Taeko、Iwabuchi Toshiki、Senju Atsushi、Nakayasu Chikako、Nakahara Ryuji、Tsuchiya Kenji J、Hoshi Yoko
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 20696-20696

    • DOI

      10.1038/s41598-022-25185-3

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Homelessness in autistic women: Defining the research agenda2022

    • Author(s)
      Lockwood Estrin Georgia、Aseervatham Victoria、De Barros Clara M、Chapple Tara、Churchard Alasdair、Harper Monique、Jones Emily JH、Mandy William、Milner Victoria、O’Brien Sarah、Senju Atsushi、Smith Chloe、Smith Jonathan
    • Journal Title

      Women's Health

      Volume: 18

    • DOI

      10.1177/17455057221141291

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of perceived eye gaze on the N170 component ? A systematic review2022

    • Author(s)
      Tautvydaite Domile, Mares Ines, Rahman Md. Shafiur, Burra Nicolas, Senju Atsushi
    • Journal Title

      Neuroscience & Biobehavioral Reviews

      Volume: 143 Pages: 104913-104913

    • DOI

      10.1016/j.neubiorev.2022.104913

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research

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Published: 2022-04-19   Modified: 2026-01-16  

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