Project/Area Number |
23K22614
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 17050:Biogeosciences-related
|
Research Institution | Tokyo Institute of Technology |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
掛川 武 東北大学, 理学研究科, 教授 (60250669)
|
Project Period (FY) |
2024-04-01 – 2025-03-31
|
Project Status |
Granted (Fiscal Year 2024)
|
Budget Amount *help |
¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2024: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
|
Keywords | enzyme / evolution / thioester / group transfer potential / origin of life |
Outline of Research at the Start |
ATP (adenosine triphosphate) is used by all known life forms. However, its is problematic for ancient life because of its molecular complexity and phosphate solubility in ancient iron rich oceans. Sulfur containing thio-esters are simple alternatives to ATP, but their use in deep time has not been investigated with a direct biochemical approach. Is sulfur more ancient than phosphate in early life? We will address this question using purified enzymes that can catalyze S and P dependent chemistry to discover the earliest mechanisms of energy conservation.
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