Project/Area Number |
23K23887
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 44010:Cell biology-related
|
Research Institution | Institute of Physical and Chemical Research |
Principal Investigator |
Phng LiKun 国立研究開発法人理化学研究所, 生命機能科学研究センター, チームリーダー (70794098)
|
Project Period (FY) |
2024-04-01 – 2025-03-31
|
Project Status |
Granted (Fiscal Year 2024)
|
Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2024: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | Endothelial cell / Actin cytoskeleton / Blood vessel remodeling / Haemodynamic forces / Mechanobiology |
Outline of Research at the Start |
The generation of a hierarchical network of larger arteries and veins and smaller capillaries of optimal vessel density is achieved through vessel remodeling, which is regulated by haemodynamic forces. Here, we seek to unravel how haemodynamic forces remodel EC actomyosin organization and junctions to regulate EC behaviors and control blood vessel diameter in the zebrafish.
|