| Project/Area Number |
23K24304
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| Project/Area Number (Other) |
22H03043 (2022-2023)
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Multi-year Fund (2024)
Single-year Grants (2022-2023) |
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| Section | 一般 |
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| Review Section |
Basic Section 52050:Embryonic medicine and pediatrics-related
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| Research Institution | Kyushu University |
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Principal Investigator |
Ohga Shouichi 九州大学, 医学研究院, 教授 (60233053)
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| Co-Investigator(Kenkyū-buntansha) |
大野 真治 琉球大学, 医学(系)研究科(研究院), 教授 (50419529)
今留 謙一 国立研究開発法人国立成育医療研究センター, 高度感染症診断部, 部長 (70392488)
井原 健二 大分大学, 医学部, 教授 (80294932)
長谷川 俊史 山口大学, 大学院医学系研究科, 教授 (90314806)
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| Project Period (FY) |
2024-04-01 – 2025-03-31
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| Project Status |
Completed (Fiscal Year 2024)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2024: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2023: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2022: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 急性心筋炎 / パルボウイルス / パルボウイルスB19 / 小児心筋炎 / 心筋症 / ウイルス受容体 / 宿主因子 |
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| Outline of Research at the Start |
私たちは急性心筋炎患児の発症時血清にヒトパルボウイルスB19（B19V）DNAを検出し、これが伝染性紅斑の流行と相関し、より重症であることを見出してきた。本研究では、15歳未満の急性心筋炎患者の末梢血、心筋組織検体と臨床情報を前後方視的に集積し、心機能回復群と未回復群の臨床像、治療経過、B19Vとの関連（血液と心筋）を解析している。
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| Outline of Final Research Achievements |
Human parvovirus B19 (B19V) DNA was detected in the serum of pediatric patients at the onset of fulminant myocarditis (FM), and its presence was found to correlate with both outbreaks of erythema infectiosum and more severe clinical manifestations. In the present study, we conducted a combined retrospective and prospective analysis, collecting peripheral blood and myocardial tissue specimens, along with comprehensive clinical data, from patients under the age of 15 diagnosed with acute myocarditis. We compared the clinical characteristics, treatment modalities, and the presence of B19V (in both blood and myocardial tissue) between patients whose cardiac function recovered and those in whom recovery was not achieved. Our findings suggest that, in cases of B19V-associated myocarditis, host factors may exert a greater influence on disease pathogenesis than the viral infection itself.
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| Academic Significance and Societal Importance of the Research Achievements |
本課題の研究を論文としてまとめ現在投稿中である（Clin Infect Dis→Pediart Res）。
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