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肝細胞のがん化における細胞間相互作用を介した星細胞の役割

Research Project

Project/Area Number 23K24322
Project/Area Number (Other) 22H03061 (2022-2023)
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeMulti-year Fund (2024)
Single-year Grants (2022-2023)
Section一般
Review Section Basic Section 53010:Gastroenterology-related
Research InstitutionOsaka Metropolitan University

Principal Investigator

河田 則文  大阪公立大学, 大学院医学研究科, 教授 (30271191)

Co-Investigator(Kenkyū-buntansha) 松原 三佐子 (佐藤三佐子)  大阪公立大学, 大学院獣医学研究科, 准教授 (00635120)
LE THITHANHTHUY  大阪公立大学, 大学院医学研究科, 准教授 (10572175)
HOANG HAI  大阪公立大学, 大学院医学研究科, 研究員 (60623246)
Project Period (FY) 2022-04-01 – 2025-03-31
Project Status Granted (Fiscal Year 2024)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2024: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2023: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2022: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Keywords星細胞 / 肝線維化 / Cytoglobin / コラーゲン / TGFβ / TGF-β / ROS
Outline of Research at the Start

継続課題のため、記入しない

Outline of Annual Research Achievements

2022年度には、ジエチルニトロサミン(DEN)を用いたin vivo肝発がんモデルを完成させ、DEN処理肝から単離した非実質細胞をシングルセルRNAシーケンス解析した。CellMarkers2.0データベースの特徴的マーカーを用いて、DEN処理したWTまたはKO腫瘍および非腫瘍サンプルの統合データを細胞アノテーションすることにより、10種類の細胞種が同定された。2023年度は、Nichnet解析による細胞間相互作用の解析を行った。静止期造血幹細胞、活性化造血幹細胞、胆管細胞、Kupffer細胞、好中球、T-NK細胞、腫瘍関連マクロファージ(TAM)から、LSECの受容体と相互作用するリガンドを同定した。我々はまず、WTとCygb-KOの造血幹細胞とLSECの相互作用に注目した。WTでは、造血幹細胞のC3リガンドとLSECのその受容体C5ar2との相互作用が有力的であり、さらにマウス肝臓から単離した初代細胞でも検証した。C3リガンドは肝細胞、造血幹細胞、免疫細胞で高発現しており、一方、C5ar2受容体はLSECで高発現していた。C3リガンドおよびその受容体C5ar2のmRNA発現レベルは、344人の肝細胞癌患者の肝細胞癌生存率と正の相関を示した。
Cygb-KO肝臓の場合、これらの細胞間の相互作用は、WT肝臓とは異なっていた。造血幹細胞とLSECの相互作用を調べたところ、造血幹細胞のSerping1リガンドとLSECのその受容体Selpの相互作用が最も効果的であった。Cygb-KOマウスの組織では、Serping1リガンドがWTマウスに比べて増加していた。さらに、初代分離細胞を用いて調べたところ、造血幹細胞-KOではSerping1が有意に高発現していた。さらに、Cygb-KOマウスの組織では、受容体Selpの発現がWTマウスに比べて上昇していた。これらの因子のmRNA発現を344例の肝細胞癌患者の生存率と比較したところ、強い正の相関が認められた。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

我々が同定した10種類の細胞種のうち、LSECが最も大きな細胞集団であったため、まず研究の対象をLSECとした。DEG解析の結果、LSECにおける遺伝子発現は、WTと比較するとKOでは合計381種類異なっていた。興味深いことに、細胞間相互作用解析にNicheNetを用いたところ、Cygb-KOニッチにおける上位20の相互作用が、WTとは異なることが判明した。各受容体-リガンドをスクリーニングし、組織および細胞レベルでの発現を検証した結果、LSECでは増殖因子、ケモカイン、接着分子、II型インターフェロンシグナル伝達経路に関連する遺伝子の発現が上昇していることがわかった。造血幹細胞とLSEC間の多数のリガンド-受容体相互作用は興味深く、さらなる解析が必要である。

Strategy for Future Research Activity

この研究結果から、造血幹細胞由来のC3、Serpring1を含む2つのリガンドとそれぞれC5ar2とSelpを含む2つのレセプターが、肝腫瘍微小環境のLSECにおいて潜在的な役割を担うことが明らかとなった。次に、肝細胞癌患者と非肝細胞癌患者の血清中のこれらの因子の測定を行う予定である。これらの因子をin vitroおよびin vivoで中和または阻害などの制御を行い、肝腫瘍形成をどのように促進または抑制するのかについて検討する。さらに
クッパー細胞、好中球、T/NK細胞、TAM細胞とLSECとの相互作用をさらに検討する。特に、肝腫瘍の発生における免疫細胞の役割は興味深い。WTニッチ由来のT/NK細胞は、Hmgb2-Dab2とXcl1-Gpr4軸を介してのみLSECと相互作用するが、Cygb-KO由来のT/NK細胞は、Apoa1-Cd36、Apob-Cd36、Calm1-Rpsa、Ccl5-Insr、Kng1-F2r、Trf-Fzd4軸を含む多くの細胞間相互作用を示した。これらの相互作用を検証し、肝発癌に関与する重要な因子を明らかにする予定である。

Report

(2 results)
  • 2023 Annual Research Report
  • 2022 Annual Research Report
  • Research Products

    (42 results)

All 2024 2023 2022

All Journal Article (28 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 21 results,  Open Access: 10 results) Presentation (13 results) (of which Int'l Joint Research: 11 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] Recent Advances in the Pathogenesis and Clinical Evaluation of Portal Hypertension in Chronic Liver Disease.2024

    • Author(s)
      Kotani K, Kawada N
    • Journal Title

      Gut Liver

      Volume: 18 Issue: 1 Pages: 27-39

    • DOI

      10.5009/gnl230072

    • Related Report
      2023 Annual Research Report
  • [Journal Article] C-CAT's triumph in gastroenterology: the wisdom of cats is infinitely superior.2024

    • Author(s)
      Enomoto M, Odagiri N, Rinka K, Maruyama H, Shimamoto Y, Ishikawa-Kakiya Y, Fujiwara Y, Kawada N, Yashiro M
    • Journal Title

      J Gastroenterol

      Volume: 59 Issue: 2 Pages: 157-158

    • DOI

      10.1007/s00535-023-02061-z

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Transcriptomics of a cytoglobin knockout mouse: Insights from hepatic stellate cells and brain2024

    • Author(s)
      Porto Elena、De Backer Joey、Thuy Le Thi Thanh、Kawada Norifumi、Hankeln Thomas
    • Journal Title

      Journal of Inorganic Biochemistry

      Volume: 250 Pages: 112405-112405

    • DOI

      10.1016/j.jinorgbio.2023.112405

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytoglobin functions as a redox regulator of melanogenesis in normal epidermal melanocytes.2024

    • Author(s)
      Tanaka Y, Sato-Matsubara M, Tsuruta D, Tanaka H, Kadono C, Sugawara K, Kawada N, Wakamatsu K, Ito S, Yoshizato K.
    • Journal Title

      Pigment Cell Melanoma Res

      Volume: 37 Issue: 2 Pages: 276-285

    • DOI

      10.1111/pcmr.13146

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Poorly Differentiated Hepatocellular Carcinoma Cells Avoid Apoptosis by Interacting with T Cells via CD40?CD40L Linkage2024

    • Author(s)
      Ngo Hanh Vinh、Thanh Le Thuy Thi、Vu Hieu Ngoc、Hoang Hai、Ikenaga Hiroko、Sato-Matsubara Misako、Uchida-Kobayashi Sawako、Urushima Hayato、Van Nguyen Khanh、Nguyen Ha Thi、Shinkawa Hiroji、Kubo Shoji、Ohtani Naoko、Enomoto Masaru、Tamori Akihiro、Kawada Norifumi
    • Journal Title

      The American Journal of Pathology

      Volume: in press Issue: 7 Pages: 1230-1247

    • DOI

      10.1016/j.ajpath.2024.03.004

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis B surface antigen glycan isomer is a predictor of the development of hepatocellular carcinoma during nucleoside/nucleotide analog therapy2024

    • Author(s)
      Kozuka R, Enomoto M, Yukawa-Muto Y, Odagiri N, Kotani K, Motoyama H, Kawamura E, Hagihara A, Fujii H, Uchida-Kobayashi S, Kawada N
    • Journal Title

      Hepatology Research

      Volume: 00 Issue: 7 Pages: 00-00

    • DOI

      10.1111/hepr.14016

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New Era of Immune-Based Therapy in Intrahepatic Cholangiocarcinoma2023

    • Author(s)
      Kawamura Etsushi、Matsubara Tsutomu、Kawada Norifumi
    • Journal Title

      Cancers

      Volume: 15 Issue: 15 Pages: 3993-3993

    • DOI

      10.3390/cancers15153993

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent updates on the role of the gut-liver axis in the pathogenesis of NAFLD/NASH, HCC, and beyond2023

    • Author(s)
      Ohtani Naoko、Kamiya Tomonori、Kawada Norifumi
    • Journal Title

      Hepatology Communications

      Volume: 7 Issue: 9

    • DOI

      10.1097/hc9.0000000000000241

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Real-world treatment outcome with protease inhibitor direct-acting antiviral in advanced hepatitis C cirrhosis: a REAL-C study.2023

    • Author(s)
      Wong YJ, Tran S, Huang CF, Hsu YC, Preda C, Toyoda H, Liu J, Jun DW, Landis C, Huang DQ, Gila A, Negoita L, Yasuda S, Tseng CH, Tsai PC, Uojima H, Nozaki A, Chuma M, Atsukawa M, Ishigami M, Itokawa N, Iio E, Lam CP, Watanabe T, Asai A, Yokohama K, Abe H, Enomoto M, Kawada N, Tamori A, Lee DH, Jun MJ, et al.
    • Journal Title

      Hepatol Int

      Volume: 1 Issue: 5 Pages: 110-1161

    • DOI

      10.1007/s12072-023-10547-4

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Posttreatment liver function, but not baseline liver function stratifies patient survival after direct-acting antiviral treatment in decompensated cirrhosis with hepatitis C virus2023

    • Author(s)
      Tahata Yuki、Hikita Hayato、Suda Goki et al.,
    • Journal Title

      Journal of Gastroenterology

      Volume: 58 Issue: 12 Pages: 1211-1221

    • DOI

      10.1007/s00535-023-02039-x

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2014 to 2018 in Japan: A large‐scale multicenter retrospective study2023

    • Author(s)
      Fujii Hideki、Suzuki Yuichiro、Ono Masafumi、Sumida Yoshio、
    • Journal Title

      Hepatology Research

      Volume: 53 Issue: 11 Pages: 1059-1072

    • DOI

      10.1111/hepr.13947

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Short-term hepatocyte function and portal hypertension outcomes of sofosbuvir/velpatasvir for decompensated hepatitis C-related cirrhosis2023

    • Author(s)
      Kotani Kohei、Enomoto Masaru、Uchida-Kobayashi Sawako、Tamori Akihiro、Yukawa-Muto Yoshimi、Odagiri Naoshi、Motoyama Hiroyuki、Kozuka Ritsuzo、Kawamura Etsushi、Hagihara Atsushi、Fujii Hideki、Kageyama Ken、Yamamoto Akira、Yoshida Atsushi、Higashiyama Shigeaki、Kawabe Joji、Kawada Norifumi
    • Journal Title

      Journal of Gastroenterology

      Volume: 58 Issue: 4 Pages: 394-404

    • DOI

      10.1007/s00535-023-01963-2

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methylated SEPT9 assay-based liquid biopsy as a biomarker in molecular targeted agent-treated hepatocellular carcinoma.2023

    • Author(s)
      Saeki I, Suehiro Y, Yamauchi Y, Hoshida T, Tanabe N, Oono T, Kawamoto D, Nishimura T, Matsumoto T, Ishikawa T, Shimokawa M, Tamori A, Kawada N, Tamai Y, Iwasa M, Nakagawa H, Nagano H, Takami T, Yamasaki T
    • Journal Title

      Hepatol Int

      Volume: 17 Issue: 5 Pages: 1289-1299

    • DOI

      10.1007/s12072-023-10488-y

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Editorial: risk of renal function decline in patients with chronic hepatitis B virus infection treated with nucleos(t)ide analogues.2023

    • Author(s)
      Kozuka R, Enomoto M, Kawada N
    • Journal Title

      Aliment Pharmacol Ther

      Volume: 58 Issue: 1 Pages: 124-125

    • DOI

      10.1111/apt.17551

    • Related Report
      2023 Annual Research Report
  • [Journal Article] A case of hepatocellular carcinoma with “pseudoprogression” followed by complete response to atezolizumab plus bevacizumab2023

    • Author(s)
      Odagiri Naoshi、Tamori Akihiro、Kotani Kohei、Motoyama Hiroyuki、Kawamura Etsushi、Hagihara Atsushi、Fujii Hideki、Uchida?Kobayashi Sawako、Enomoto Masaru、Kawada Norifumi
    • Journal Title

      Clinical Journal of Gastroenterology

      Volume: - Issue: 3 Pages: 392-396

    • DOI

      10.1007/s12328-023-01761-6

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcatheter Arterial Chemoembolization for Treatment-Naive Hepatocellular Carcinoma Has Different Treatment Effects Depending on Central or Peripheral Tumor Location2023

    • Author(s)
      Asano Kazuo、Kageyama Ken、Yamamoto Akira、Jogo Atsushi、Uchida-Kobayashi Sawako、Sohgawa Etsuji、Murai Kazuki、Kawada Norifumi、Miki Yukio
    • Journal Title

      Liver Cancer

      Volume: 12 Issue: 6 Pages: 576-589

    • DOI

      10.1159/000530441

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multicenter, retrospective, cohort study shows platelet counts predict hepatocellular carcinoma development in patients with nonalcoholic fatty liver disease2023

    • Author(s)
      Fujii Hideki、Fujii Makoto、Iwaki Michihiro、Hayashi Hideki、Toyoda Hidenori、Oeda Satoshi、Hyogo Hideyuki、Kawanaka Miwa、Morishita Asahiro、Munekage Kensuke、et al.
    • Journal Title

      Hepatology Research

      Volume: 53 Issue: 5 Pages: 391-400

    • DOI

      10.1111/hepr.13884

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Severity of Liver Fibrosis Is Associated with the Japanese Diet Pattern and Skeletal Muscle Mass in Patients with Nonalcoholic Fatty Liver Disease2023

    • Author(s)
      Matsumoto Yoshinari、Fujii Hideki、Harima Mika、Okamura Haruna、Yukawa-Muto Yoshimi、Odagiri Naoshi、Motoyama Hiroyuki、Kotani Kohei、Kozuka Ritsuzo、Kawamura Etsushi、Hagihara Atsushi、Uchida-Kobayashi Sawako、Enomoto Masaru、Yasui Yoko、Habu Daiki、Kawada Norifumi
    • Journal Title

      Nutrients

      Volume: 15 Issue: 5 Pages: 1175-1175

    • DOI

      10.3390/nu15051175

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased spine bone density in patients with chronic hepatitis B switched to tenofovir alafenamide: A prospective, multinational study2023

    • Author(s)
      Ogawa E, Jun DW, Toyoda H, Hsu YC, Yoon EL, Ahn SB, Yeh ML, Do S, Trinh HN, Takahashi H, Enomoto M, Kawada N, Yasuda S, Tseng CH, Kawashima K, Lee HA, Inoue K, Haga H, Do AT, Maeda M, Hoang JH, Cheung R, Ueno Y, Eguchi Y, Furusyo N, Yu ML, Tanaka Y, Nguyen MH
    • Journal Title

      Alimentary Pharmacology & Therapeutics

      Volume: 59 Issue: 2 Pages: 239-248

    • DOI

      10.1111/apt.17785

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Nitric Oxide Derived from Cytoglobin-Deficient Hepatic Stellate Cells Causes Suppression of Cytochrome c Oxidase Activity in Hepatocytes2023

    • Author(s)
      Yoshinori Okina, Misako Sato-Matsubara, Yasutoshi Kido, Hayato Urushima, Atsuko Daikoku, Chiho Kadono, Yu Nakagama, Yuko Nitahara, Truong Huu Hoang, Le Thi Thanh Thuy, Tsutomu Matsubara, Naoko Ohtani, Kazuo Ikeda, Katsutoshi Yoshizato, Norifumi Kawada.
    • Journal Title

      Antioxid Redox Signal.

      Volume: 38 Pages: 463-479

    • DOI

      10.1089/ars.2021.0279

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Risk factors for liver‐related and non‐liver‐related mortality following a sustained virological response after direct‐acting antiviral treatment for hepatitis C virus infection in a real‐world cohort2023

    • Author(s)
      Kozuka Ritsuzo、Tamori Akihiro、Enomoto Masaru、Muto‐Yukawa Yoshimi、Odagiri Naoshi、Kotani Kohei、Motoyama Hiroyuki、Kawamura Etsushi、Hagihara Atsushi、Fujii Hideki、Uchida‐Kobayashi Sawako、Kawada Norifumi
    • Journal Title

      Journal of Viral Hepatitis

      Volume: 30 Issue: 5 Pages: 374-385

    • DOI

      10.1111/jvh.13795

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations.2023

    • Author(s)
      Kaur S*, Kidambi S*, Ortega-Ribera M*, Thuy LTT*, Nieto N, Cogger V, Xie WF, Frank Tacke, Gracia-Sancho J
    • Journal Title

      Cellular and Molecular Gastroenterology and Hepatology

      Volume: 15 Issue: 3 Pages: 559-571

    • DOI

      10.1016/j.jcmgh.2022.11.008

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical Outcomes in Biopsy-Proven Nonalcoholic Fatty Liver Disease Patients: A Multicenter Registry-based Cohort Study2022

    • Author(s)
      Fujii Hideki、Masato Yoneda、Okanoue Takeshi
    • Journal Title

      Clinical Gastroenterology and Hepatology

      Volume: in press Issue: 2 Pages: 370-379

    • DOI

      10.1016/j.cgh.2022.01.002

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Gasdermin D-mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma2022

    • Author(s)
      Yamagishi R, Kamachi F, Nakamura M, Yamazaki S, Kamiya T, Takasugi M, Cheng Y, Nonaka Y, Yukawa-Muto Y, Thuy LTT, Harada Y, Arai T, Loo TM, Yoshimoto S, Ando T, Nakajima M, Taguchi H, Ishikawa T, Akiba H, Miyake S, Kubo M, Iwakura Y, Fukuda S, Chen WY, Kawada N, Rudensky A, Nakae S, Hara E, Ohtani N
    • Journal Title

      Science Immunology

      Volume: 7 Issue: 72 Pages: abl7209

    • DOI

      10.1126/sciimmunol.abl7209

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2020472

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Soluble Immune Checkpoint Protein CD27 Is a Novel Prognostic Biomarker of Hepatocellular Carcinoma Development in Hepatitis C Virus?Sustained Virological Response Patients2022

    • Author(s)
      Dong Minh Phuong、Thuy Le Thi Thanh、Hoang Dinh Viet、Hai Hoang、Hoang Truong Huu、Sato-Matsubara Misako、Hieu Vu Ngoc、Daikoku Atsuko、Hanh Ngo Vinh、Urushima Hayato、Dat Ninh Quoc、Uchida-Kobayashi Sawako、Enomoto Masaru、Ohtani Naoko、Tamori Akihiro、Kawada Norifumi
    • Journal Title

      The American Journal of Pathology

      Volume: 192 Issue: 10 Pages: 1379-1396

    • DOI

      10.1016/j.ajpath.2022.07.003

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cancer cells produce liver metastasis via gap formation in sinusoidal endothelial cells through proinflammatory paracrine mechanisms.2022

    • Author(s)
      Huu Hoang T, Sato-Matsubara M, Yuasa H, Matsubara T, Thuy LTT, Ikenaga H, Phuong DM, Hanh NV, Hieu VN, Hoang DV, Hai H, Okina Y, Enomoto M, Tamori A, Daikoku A, Urushima H, Ikeda K, Dat NQ, Yasui Y, Shinkawa H, Kubo S, Yamagishi R, Ohtani N, Yoshizato K, Gracia-Sancho J, Kawada N.
    • Journal Title

      Sci Adv.

      Volume: 8(39) Issue: 39 Pages: 5525-5525

    • DOI

      10.1126/sciadv.abo5525

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Capacity of extracellular globins to reduce liver fibrosis via scavenging reactive oxygen species and promoting MMP-1 secretion.2022

    • Author(s)
      Hieu VN, Thuy LTT, Hai H, Dat NQ, Hoang DV, Hanh NV, Phuong DM, Hoang TH, Sawai H, Shiro Y, Sato-Matsubara M, Oikawa D, Tokunaga F, Yoshizato K, Kawada N.
    • Journal Title

      Redox Biol.

      Volume: 52 Pages: 102286-102286

    • DOI

      10.1016/j.redox.2022.102286

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cytoglobin attenuates pancreatic cancer growth via scavenging reactive oxygen species2022

    • Author(s)
      Hoang Dinh Viet、Thuy Le Thi Thanh、Hai Hoang、Hieu Vu Ngoc、Kimura Kenjiro、Oikawa Daisuke、Ikura Yoshihiro、Dat Ninh Quoc、Hoang Truong Huu、Sato-Matsubara Misako、Dong Minh Phuong、Hanh Ngo Vinh、Uchida-Kobayashi Sawako、Tokunaga Fuminori、Kubo Shoji、Ohtani Naoko、Yoshizato Katsutoshi、Kawada Norifumi
    • Journal Title

      Oncogenesis

      Volume: 11 Issue: 1 Pages: 1-13

    • DOI

      10.1038/s41389-022-00389-4

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Cell-cell interaction of LSECs-HSCs in the microenvironment of Diethyl nitrosamine treated Cytoglobin Knock-out mice.2024

    • Author(s)
      Nguyen Thi Ha, Le Thi Thanh Thuy, Hoang Hai, Pham Minh Duc, Ngo Vinh Hanh, Nguyen Van Khanh, Nguyen Tran Quang Sang, Inoue Mana, Norifumi Kawada
    • Organizer
      The Asian Pacific Association for the Study of the Liver (APASL) 2024
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Single-cell RNA sequencing analysis of non-parenchymal cells in liver fibrosis progression and regression.2024

    • Author(s)
      Pham Minh Duc, Le Thi Thanh Thuy, Hoang Hai, Nguyen Thi Ha, Norifumi Kawada
    • Organizer
      The Asian Pacific Association for the Study of the Liver (APASL) 2024
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Soluble PD-1 and BTLA proteins as biomarkers for predicting the anti-HBV treatment responsiveness.2024

    • Author(s)
      Hoang Hai, Masaru Enomoto, Le Thi Thanh Thuy, Naoshi Odagiri, Kohei Kotani, Hiroyuki Motoyama, Ritsuzo Kozuka, Atsushi Hagihara, Etsushi Kawamura, Hideki Fujii, Sawako Uchida-Kobayashi, and Norifumi Kawada
    • Organizer
      The Asian Pacific Association for the Study of the Liver (APASL) 2024
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Single-cell RNA sequencing analysis of non-parenchymal cells in liver fibrosis progression and regression.2023

    • Author(s)
      Pham Minh Duc, Le Thi Thanh Thuy, Hoang Hai, Nguyen Thi Ha and Norifumi Kawada
    • Organizer
      第37回肝類洞壁細胞研究会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Interaction between HSC and LSEC populations in the premalignant environment of DEN-treated Cytoglobin knock-out mice.2023

    • Author(s)
      Nguyen Thi Ha, Le Thi Thanh Thuy, Pham Minh Duc, Ngo Vinh Hanh, Nguyen Van Khanh, Nguyen Tran Quang Sang, Inoue Mana, Kawada N
    • Organizer
      The APASL Oncology 2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The promising therapeutics of recombinant human cytoglobin against acetaminophen-induced liver injury.2023

    • Author(s)
      Pham Minh Duc, Le Thi Thanh Thuy, Hoang Hai, Nguyen Thi Ha, Vu Ngoc Hieu, Kawada N
    • Organizer
      The 3rd Japan Society of Hepatology International Liver Conference
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Role of Cytoglobin in Liver Fibrosis and Steatohepatitis.2023

    • Author(s)
      Le Thi Thanh Thuy, Hoang Hai, and Kawada N
    • Organizer
      The 3rd Japan Society of Hepatology International Liver Conference
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] CD40 expression in liver cancer cells is upregulated by CD4+T cells through IFN gamma and ERK 1/2 pathway.2023

    • Author(s)
      Ngo Vinh Hanh, Le Thi Thanh Thuy, Hoang Hai, Vu Ngoc Hieu, Sawako Uchida-Kobayashi, Masaru Enomoto, Akihiro Tamori and Kawada N
    • Organizer
      European Association for the Study of Liver Annual Congress (EASL) 2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Therapeutic effect of recombinant human Cytoglobin against mouse liver fibrosis and stellate cell activation via ROS scavenger function and activation of JAK-STAT1 pathway.2023

    • Author(s)
      Kawada N, Pham Minh Duc, Le Thi Thanh Thuy, and Hoang Hai
    • Organizer
      European Association for the Study of Liver Annual Congress (EASL) 2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Baseline sCD27, sCD28, and sCD40 levels - novel predictors of HCC development in HCV-SVR patients2023

    • Author(s)
      Le Thi Thanh Thuy, Minh Phuong Dong, Hoang Hai, Sawako Uchida-Kobayashi, Masaru Enomoto, Akihiro Tamori and Norifumi Kawada
    • Organizer
      the 32nd Annual Meeting of Asian Pacific Association for the Study of the Liver (APASL)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Soluble immune checkpoint protein CD27 is a novel prognostic predictor of HCC development in HCV-SVR patients2022

    • Author(s)
      Le Thi Thanh Thuy, Minh Phuong Dong, Hoang Hai, Vu Ngoc Hieu, Dinh Viet Hoang, Sawako Uchida-Kobayashi, Masaru Enomoto, Akihiro Tamori and Norifumi Kawada
    • Organizer
      Annual Meeting of American Association for the Study of Liver Diseases (AASLD)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Anti-fibrotic Capacity of Extracellular Globins via Scavenging Reactive Oxygen Species2022

    • Author(s)
      Le Thi Thanh Thuy, Vu Ngoc Hieu, Hoang Hai, and Norifumi Kawada
    • Organizer
      XXI International Conference on Oxygen Binding and Sensing Proteins (O2BIP)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cytoglobin, Neuroglobin, Myoglobin, but not Hemoglobin Exhibited Anti-Fibrotic Properties In Vitro and In Vivo2022

    • Author(s)
      Le Thi Thanh Thuy, Vu Ngoc Hieu, Hoang Hai, Dinh Viet Hoang, and Norifumi Kawada
    • Organizer
      the 58th Annual Meeting of the Japan Society of Hepatology
    • Related Report
      2022 Annual Research Report
  • [Book] Sinusoidal Cells in Liver Diseases: Role in their Pathophysiology, Diagnosis, and Treatment2024

    • Author(s)
      Jordi Gracia-Sancho
    • Total Pages
      562
    • Publisher
      Academic Press
    • ISBN
      9780323952620
    • Related Report
      2023 Annual Research Report

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Published: 2022-04-19   Modified: 2024-12-25  

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