| Project/Area Number |
23K25176
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| Project/Area Number (Other) |
22H03922 (2022-2023)
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Multi-year Fund (2024)
Single-year Grants (2022-2023) |
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| Section | 一般 |
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| Review Section |
Basic Section 90110:Biomedical engineering-related
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| Research Institution | Chiba University |
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Principal Investigator |
ゴメスタメス ホセデビツト 千葉大学, フロンティア医工学センター, 准教授 (60772902)
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| Co-Investigator(Kenkyū-buntansha) |
兪 文偉 千葉大学, フロンティア医工学センター, 教授 (20312390)
大鶴 直史 新潟医療福祉大学, リハビリテーション学部, 教授 (50586542)
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| Project Period (FY) |
2022-04-01 – 2025-03-31
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| Project Status |
Granted (Fiscal Year 2024)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2024: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2023: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2022: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
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| Keywords | Brain Stimulation / Neural Engineering / Computational Biophysics / Deep Stimulation / Medical Imaging / Interferential / Brain stimulation |
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| Outline of Research at the Start |
Brain stimulation is a therapeutic modality that uses electrical stimulation to control/regulate brain functions. There is high interest in targetting deep brain parts as a potential treatment of neurological disorders using non-invasive electrical stimulation. However, deep brain stimulation is difficult without superficial stimulation. A multiscale electrophysiological model is developed to investigate interferential stimulation as a method for achieving focal stimulation together with experimental measurements.
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| Outline of Annual Research Achievements |
Based on the aim of developing a personalized computational physical model for focal and deep brain stimulation, we investigated stimulation dose characteristics using a combined approach of numerical and experimental techniques. The experiments showed the possibility of focal stimulation of individual hand fingers that are condensed in a small area of the brain demonstrating focality with high resolution. In addition, new insight into the dual-hemisphere transcranial stimulation application was presented for deep cortical stimulation of the lower limb. Finally, progress in the development of a micro-physical neuron model integrated with the personalized brain stimulation simulator was achieved to investigate interferential phenomena.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
The developed personalized computational physical model for investigating focal and deep brain stimulation characteristics is in place. Simulation and experiments were conducted showing the feasibility of focal and deep stimulation providing a better understanding of the characteristics of the generated electric currents in the brain in terms of focality and depth. The model integrated the micro-physical brain neuron to investigate independent kilohertz stimulation and a combination of two-kilohertz stimulation (i.e., interferential stimulation) for further characterization of deep and focal brain stimulations. Publications in recognized journals and top conferences in the field demonstrate the progress of the work.
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| Strategy for Future Research Activity |
In FY2023, the multiscale electrophysiological model will be further improved and validated to investigate focal and deep stimulation. For validation, we will conduct an extended revision of stimulation parameters to achieve personalized focal stimulation. Further, the mechanism of stimulation of kilohertz electric currents (including interferential) will be investigated based on simulations together with experimental measurements. The original plan included brain stimulation at kilohertz currents but they became prohibitive considering the required high electric currents in the brain for evoked responses in recent reports (Wang et.al., 2023, Neural Eng). In substitution, mechanisms of kilohertz stimulation will be investigated in experiments of the peripheral nervous system.
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