| Project/Area Number |
23K25176
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| Project/Area Number (Other) |
22H03922 (2022-2023)
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Multi-year Fund (2024)
Single-year Grants (2022-2023) |
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| Section | 一般 |
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| Review Section |
Basic Section 90110:Biomedical engineering-related
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| Research Institution | Chiba University |
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Principal Investigator |
ゴメスタメス ホセデビツト 千葉大学, フロンティア医工学センター, 准教授 (60772902)
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| Co-Investigator(Kenkyū-buntansha) |
兪 文偉 千葉大学, フロンティア医工学センター, 教授 (20312390)
大鶴 直史 新潟医療福祉大学, リハビリテーション学部, 教授 (50586542)
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| Project Period (FY) |
2022-04-01 – 2025-03-31
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| Project Status |
Granted (Fiscal Year 2024)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2024: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2023: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2022: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
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| Keywords | Brain Stimulation / Neural Engineering / Computational Biophysics / Deep Stimulation / Brain stimulation / Temporal Stimulation / Medical Imaging / Interferential |
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| Outline of Research at the Start |
Brain stimulation is a therapeutic modality that uses electrical stimulation to control/regulate brain functions. There is high interest in targetting deep brain parts as a potential treatment of neurological disorders using non-invasive electrical stimulation. However, deep brain stimulation is difficult without superficial stimulation. A multiscale electrophysiological model is developed to investigate interferential stimulation as a method for achieving focal stimulation together with experimental measurements.
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| Outline of Annual Research Achievements |
We continued the investigation on precise focal deep brain stimulation based on a high-resolution physical model of the human head model for non-invasive brain stimulation. Firstly, the conducted studies demonstrated focal stimulation of deep brain tissues, achieved with reduced co-stimulation through interferential stimulation approach, presenting a marked improvement over conventional methods. Secondly, new insights were gained for deep cortical stimulation of the lower limb during dual-hemisphere stimulation protocol. Finally, progress was made in the development of micro-physical neuron model to investigate further interferential phenomena.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
The developed personalized computational physical model for investigating focal and deep brain stimulation characteristics is in place. Simulation and experiments were conducted showing the feasibility of focal and deep stimulation providing a better understanding of the characteristics of the generated electric currents in the brain in terms of focality and depth. The model integrated the micro-physical brain neuron to investigate independent kilohertz stimulation and a combination of two-kilohertz stimulation (i.e., interferential stimulation) for further characterization of deep and focal brain stimulations. Publications in recognized journals and top conferences in the field demonstrate the progress of the work.
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| Strategy for Future Research Activity |
In FY2024, we will conduct an extended revision of stimulation parameters to optimize individualized-level and population-level focal deep brain stimulation. The multiscale electrophysiological model will undergo further refinement to explore focal and deep stimulation mechanisms, particularly focusing on high-frequency brain modulation. This will be grounded on mechanisms of high-frequency stimulation through experiments on the peripheral nervous system.
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