Project/Area Number |
23K25188
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 90110:Biomedical engineering-related
|
Research Institution | The University of Tokyo |
Principal Investigator |
LECLERC Eric 東京大学, 大学院工学系研究科(工学部), 外国人客員研究員 (30759436)
|
Co-Investigator(Kenkyū-buntansha) |
酒井 康行 東京大学, 大学院工学系研究科(工学部), 教授 (00235128)
|
Project Period (FY) |
2024-04-01 – 2025-03-31
|
Project Status |
Granted (Fiscal Year 2024)
|
Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2024: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
|
Keywords | liver organ on chip / stem cells / fibrosis / fatty acids |
Outline of Research at the Start |
The purpose of the research is to develop tri culture model of liver derived human induced pluripotent stem cells to build a hepatic tissue. Then we proposed to investigate liver disorder. We wish to induce a hepatic fibrosis like disorder using physio pathological sequence due to free fatty acids exposure within organ on chip technology. Finally we aim at testing an anti fibrotic treatment as one exemple of one therapeutical strategy.
|