Pump field probe magnetic field effect fluorescence microscopy for time-resolved radical pair detection in biological systems

Research Project

Project/Area Number	23K26612
Project/Area Number (Other)	23H01919 (2023)
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Multi-year Fund (2024) Single-year Grants (2023)
Section	一般
Review Section	Basic Section 32010:Fundamental physical chemistry-related
Research Institution	The University of Tokyo
Principal Investigator	ウッドワードジョナサン東京大学, 大学院総合文化研究科, 教授 (80526054)
Project Period (FY)	2023-04-01 – 2026-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000) Fiscal Year 2025: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2024: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2023: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Keywords	磁気受容 / ラジカル反応 / 発光分析 / 磁場効果 / スピン化学
Outline of Research at the Start	The role of quantum mechanics in biological systems has started to be widely appreciated. A key example is biological magnetosensitivity arising from the formation of radical pairs directly in the cells of living systems. To characterise these effects and species, new instruments are required that are extremely sensitive and that can discern quantum effects of electron spin. This p roject will develop and implement a new fluorescence microscope imaging technique which can extract direct time-resolved and magnetic information about short-lived radical pair species formed in living cells.