分子ひずみを活用する生体機能分子の創出

• Project/Area Number: 23K27295
• Project/Area Number (Other): 23H02604 (2023)
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Multi-year Fund (2024); Single-year Grants (2023)
• Section: 一般
• Review Section: Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related; Basic Section 47050:Environmental and natural pharmaceutical resources-related; Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related
• Research Institution: Kyoto University
• Principal Investigator: 高須 清誠 京都大学, 薬学研究科, 教授 (10302168)
• Co-Investigator(Kenkyū-buntansha): 服部 明 京都大学, 薬学研究科, 准教授 (50300893) ; 黒田 悠介 京都大学, 薬学研究科, 特定助教 (60870863)
• Project Period (FY): 2023-04-01 – 2026-03-31
• Project Status: Granted (Fiscal Year 2024)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2025: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2024: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2023: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
• Keywords: 分子ひずみ / 生物活性分子 / フロー合成 / 多環芳香族炭化水素 / 有機合成 / 分子不斉

Outline of Research at the Start

柔軟かつ精密に設計可能なひずみ分子を基盤とした新たな生体環境適合型反応を確立し、化学修飾生体材料・外部刺激応答分子・局所エネルギー出力分子など特異な働きを示す機能分子の創出を実証し、生命化学領域に有用なひずみ分子の開拓を目指す。