Understanding the mechanism of sleep-wake cycle regulation from the cross-talk between molecule and cell

• Project/Area Number: 23K27354
• Project/Area Number (Other): 23H02663 (2023)
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Multi-year Fund (2024); Single-year Grants (2023)
• Section: 一般
• Review Section: Basic Section 48020:Physiology-related
• Research Institution: University of Tsukuba
• Principal Investigator: 史 蕭逸 筑波大学, 国際統合睡眠医科学研究機構, 助教 (40803656)
• Project Period (FY): 2023-04-01 – 2026-03-31
• Project Status: Granted (Fiscal Year 2024)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2025: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2024: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2023: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 睡眠 / シナプス可塑性

Outline of Research at the Start

本研究は、睡眠恒常性の実現に資する細胞と分子のクロストークを理解するものである。特に、シナプス強度という階層を中心に、睡眠制御遺伝子と個体の睡眠の制御を繋ぐ細胞レベルの制御機序を明らかにすることを目指す。