• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Pathogenetic analysis of invasive mucinous adenocarcinoma

Research Project

Project/Area Number 23K27389
Project/Area Number (Other) 23H02698 (2023)
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeMulti-year Fund (2024)
Single-year Grants (2023)
Section一般
Review Section Basic Section 49020:Human pathology-related
Research InstitutionNational Cancer Center Japan

Principal Investigator

谷田部 恭  国立研究開発法人国立がん研究センター, 中央病院, 科長 (90280809)

Co-Investigator(Kenkyū-buntansha) 岸川 さつき  国立研究開発法人国立がん研究センター, 中央病院, 医員 (10906598)
加島 淳平  国立研究開発法人国立がん研究センター, 中央病院, 短期レジデント (80893883)
小林 祥久  国立研究開発法人国立がん研究センター, 研究所, 研究員 (30734628)
Project Period (FY) 2023-04-01 – 2026-03-31
Project Status Granted (Fiscal Year 2024)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2025: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2024: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2023: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywords肺腺癌 / 浸潤性粘液腺癌 / KRAS / KRAS変異 / 喫煙者肺腺癌 / アイソフォーム / 発現解析 / 前駆病変
Outline of Research at the Start

浸潤性粘液腺癌は形態学的に気管支関連上皮との関連が指摘されてきたが、発生部位は末梢肺実質でTTF-1も陰性を示し、特徴的な腺癌といえる。これまでの解析から浸潤性粘液腺癌では発現KRASアイソフォームが異なることを見出した。その結果をさらに発展させ、肺腺癌としては通常型腺癌とは異なり、腸への分化を示す特徴的な腺癌の病態形成を明らかにすることで、肺腺癌の全体の特徴を明らかとしたい。そのため、以下の3つの観点から検討を行う。
1. KRAS変異アリルと遺伝子増幅・アイソフォームの解析
2. 浸潤性粘液腺癌における前駆病変・進展過程の解明
3. 異型腺腫様過形成でのKRASアイソフォームの違い

Outline of Annual Research Achievements

KRAS陽性肺腫瘍は、KRAS-AAH、非喫煙者末梢型KRAS肺癌、喫煙関連KRAS腺癌、浸潤性粘液腺癌などに大別することができる。また、KRAS変異は生物学的にcellular senescenceとoncogenicの逆説的な役割を有することが知られており、臓器・細胞の特性やKRAS変異バリアント、KRAS変異isoformsの発現割合などによってその生物学的役割が異なることが報告されている。そこで本研究では、肺癌におけるKRAS変異の生物学的意義について検討を試みる。KRAS変異を有する肺腺癌179例を全エクソーム解析、トランスクリプトーム解析を行い、その分子生物学的、臨床病理学的に違いがあるか検討した。その結果、 14例の非喫煙者末梢型KRAS肺癌、95例の喫煙関連KRAS腺癌、49例の浸潤性粘液腺癌、3例の喫煙関連KRAS扁平上皮癌、その他の18例に大別することができた。unsupervised hierarchical clusteringで喫煙者KRAS肺癌と浸潤性粘液腺癌では異なるクラスターを形成するほか、KRAS変異バリアントの分布も異なり、KRASアイソフォームの発現量に違いが見られた。これら解析の中で浸潤性粘液性腺癌の一部では、突然未分化癌に転化し、明瞭な結節を形成する現象が少数ながらも見いだされ、その生物学的意義について解析し、同一クローンによる腫瘍の脱分化現象であることを報告した。さらに、肺組織のマスター制御因子であるTTF-1変異は浸潤性粘液性腺癌で特異的に見いだされ、その空間トランスクリプトームを行っている。また、解剖学的特徴とそれに関連する発生機序から見た非小細胞肺癌全体の中での浸潤性粘液腺癌の位置づけや特殊性を分子生物学的にレビューし、国際病理学会の英国機関誌に発表した。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

KRAS変異を有する肺腺癌179例を全エクソーム解析、トランスクリプトーム解析を行い、そのunsupervised hierarchical clusteringで喫煙者KRAS肺癌と浸潤性粘液腺癌では異なるクラスターを形成することが明らかになった。現在では公開されているTCGAデータを合わせて、アイソフォームの発現パターンの解析によっても検証されていることを確認している。これら結果をまとめ、雑誌投稿中である。また、浸潤性粘液腺癌におけるTTF-1の変異についてはframeshift insertion/deletion, structural variation deletion, nonsense mutationsが多くの症例で検出されており、その発現低下を裏付ける結果が得られている。これら解析の中で浸潤性粘液性腺癌の一部では、突然未分化癌に転化し、明瞭な結節を形成する現象が少数ながらも見いだされ、そのクローン性も含めてそのメカニズムや生物学的意義について解析た結果については、「粘液結節を伴う浸潤性粘液腺癌」として英文誌に発表した。さらに、解剖学的特徴とそれに関連する発生機序から見た非小細胞肺癌全体の中での浸潤性粘液腺癌の位置づけや特殊性を分子生物学的にレビューし、国際病理学会の英国機関誌に発表した。

Strategy for Future Research Activity

これまでは浸潤性粘液腺癌にKRAS変異が多いことに着目し、に検討を行ってきた。その結果、その特徴を示すことができたが、その結果に加えてもう一つの特徴である浸潤性粘液腺癌におけるTTF-1の変異について検討を進めていきたい。通常型腺癌においてはTTF-1が遺伝子増幅を示し、高悪性度や転移能と相関することをすることをこれまでの解析で示してきた。しかしながら、浸潤性粘液腺癌では機能喪失変異を来すという点で特徴的であり、両者の違いを示すことで浸潤性粘液腺癌の特徴を追求していきたい。具体的には、通常型腺癌から浸潤性粘液腺癌への移行を示す腺癌を取り上げ、その変異の腫瘍内における分布や発現パターンの変化について空間トランスクリプトームを用いて検討を進めていきたい。

Report

(1 results)
  • 2023 Annual Research Report
  • Research Products

    (45 results)

All 2024 2023 2022

All Journal Article (39 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 38 results,  Open Access: 21 results) Presentation (6 results)

  • [Journal Article] Molecular pathology of non-small cell carcinoma2024

    • Author(s)
      Yatabe Y.
    • Journal Title

      Histopathology

      Volume: 84 Issue: 1 Pages: 50-66

    • DOI

      10.1111/his.15080

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rare but clinically important salivary gland-type tumor of the lung: A review2024

    • Author(s)
      Takamori S., Yatabe Y., Osoegawa A., Aokage K., Yoshioka H., Miyoshi T., ...Watanabe S. I.
    • Journal Title

      Jpn J Clin Oncol

      Volume: 54 Issue: 2 Pages: 121-128

    • DOI

      10.1093/jjco/hyad154

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimizing tissue stewardship in non-small cell lung cancer to support molecular characterization and treatment selection: statement from a working group of thoracic pathologists2024

    • Author(s)
      Kerr K. M., Bubendorf L., Lopez-Rios F., Khalil F., Roy-Chowdhuri S., Joubert P., ...Dacic S.
    • Journal Title

      Histopathology

      Volume: 84 Issue: 3 Pages: 429-439

    • DOI

      10.1111/his.15078

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impact of (18)F-FDG PET on TNM Staging and Prognosis in Thymic Epithelial Tumors2024

    • Author(s)
      Akamine T., Nakagawa K., Ito K., Watanabe H., Yotsukura M., Yoshida Y., ...Watanabe S. I.
    • Journal Title

      Ann Surg Oncol

      Volume: 31 Issue: 1 Pages: 192-200

    • DOI

      10.1245/s10434-023-14328-z

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inflammatory Rhabdomyoblastic Tumor: Clinicopathologic and Molecular Analysis of 13 Cases2024

    • Author(s)
      Odate T, Satomi K, Kubo T, Matsushita Y, Ueno T, Kurose A, Shomori K, Nakai T, Watanabe R, Segawa K, Ohshika S, Miyake N, Kudo S, Shimoi T, Kobayashi E, Komiyama M, Yoshimoto S, Nakatani F, Kawai, A, Yatabe Y, Kohsaka S, Ichimura K, Ichikawa H, Yoshida Akihiko
    • Journal Title

      Modern Pathology

      Volume: 37 Issue: 1 Pages: 100359-100359

    • DOI

      10.1016/j.modpat.2023.100359

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Myxoid liposarcoma with nuclear pleomorphism: a clinicopathological and molecular study2024

    • Author(s)
      Kojima Naoki、Kubo Takashi、Mori Taisuke、Satomi Kaishi、Matsushita Yuko、Iwata Shintaro、Yatabe Yasushi、Ichimura Koichi、Kawai Akira、Ichikawa Hitoshi、Yoshida Akihiko
    • Journal Title

      Virchows Archiv

      Volume: 484 Issue: 1 Pages: 71-81

    • DOI

      10.1007/s00428-023-03631-5

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The evolution of cancer genomic medicine in Japan and the role of the National Cancer Center Japan2023

    • Author(s)
      Yoshida T., Yatabe Y., Kato K., Ishii G., Hamada A., Mano H., ...Kohno T.
    • Journal Title

      Cancer Biol Med

      Volume: 21 Pages: 29-44

    • DOI

      10.20892/j.issn.2095-3941.2023.0036

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comments on the Article by Miura et al.: “Comparable Clinical Benefit Between Different Subsets Selected by PD-L1 22C3 and SP142 Tests”2023

    • Author(s)
      Yatabe Yasushi
    • Journal Title

      JTO Clinical and Research Reports

      Volume: 4 Issue: 3 Pages: 100492-100492

    • DOI

      10.1016/j.jtocrr.2023.100492

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adjuvant Osimertinib vs. Placebo in Completely Resected Stage IA2-IA3 EGFR-Mutated NSCLC: ADAURA22023

    • Author(s)
      Tsutani Y., Goldman J. W., Dacic S., Yatabe Y., Majem M., Huang X., ...He J.
    • Journal Title

      Clin Lung Cancer

      Volume: 24 Issue: 4 Pages: 376-380

    • DOI

      10.1016/j.cllc.2023.02.002

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Defining Morphologic Features of Invasion in Pulmonary Nonmucinous Adenocarcinoma With Lepidic Growth: A Proposal by the International Association for the Study of Lung Cancer Pathology Committee2023

    • Author(s)
      Thunnissen Erik、Beasley Mary Beth、Borczuk Alain、Dacic Sanja、Kerr Keith M.、Lissenberg-Witte Birgit、Minami Yuko、Nicholson Andrew G.、Noguchi Masayuki、Sholl Lynette、Tsao Ming-Sound、Le Quesne John、Roden Anja C.、Chung Jin-Haeng、Yoshida Akihiko、Moreira Andre L.、et al. Motoi Noriko、et al.
    • Journal Title

      Journal of Thoracic Oncology

      Volume: 18 Issue: 4 Pages: 447-462

    • DOI

      10.1016/j.jtho.2022.11.026

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pediatric Precision Medicine at the National Cancer Center Japan: Prospective Genomic Study of Pediatric Patients with Cancer as Part of the TOP-GEAR Project2023

    • Author(s)
      Tao Kayoko、Ohira Miki、他19名
    • Journal Title

      JCO Precision Oncology

      Volume: 7 Issue: 7

    • DOI

      10.1200/po.22.00266

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Whole Exome Sequencing of Thymoma Patients Exhibiting Exceptional Responses to Pemetrexed Monotherapy2023

    • Author(s)
      Tanaka T., Goto Y., Horie M., Masuda K., Shinno Y., Matsumoto Y., ...Ohe Y.
    • Journal Title

      Cancers (Basel)

      Volume: 15 Issue: 16 Pages: 0-0

    • DOI

      10.3390/cancers15164018

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Real‐world study of next‐generation sequencing diagnostic biomarker testing for patients with lung cancer in Japan2023

    • Author(s)
      Takahashi Toshiaki、Nishio Makoto、Nishino Kazumi、Yoshiki Yasumasa、Shiraiwa Naoko、Emir Birol、Iadeluca Laura、Yatabe Yasushi、Nishio Kazuto
    • Journal Title

      Cancer Science

      Volume: in press Issue: 6 Pages: 2524-2533

    • DOI

      10.1111/cas.15752

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of age for overall survival in head and neck sarcoma2023

    • Author(s)
      Suzuki Hidenori、Takano Gaku、Tsukushi Satoshi、Ando Masashi、Yatabe Yasushi、Kodaira Takeshi、Nishikawa Daisuke、Beppu Shintaro、Hasegawa Yasuhisa、Hanai Nobuhiro
    • Journal Title

      Medicine

      Volume: 102 Issue: 7 Pages: e32966-e32966

    • DOI

      10.1097/md.0000000000032966

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Keratin‐positive fibrotic extraskeletal myxoid chondrosarcoma: a close mimic of myoepithelial tumour2023

    • Author(s)
      Sugino Hirokazu、Iwata Shintaro、Satomi Kaishi、Mori Taisuke、Nobusawa Sumihito、Nagashima Toshiteru、Matsushita Yuko、Yatabe Yasushi、Ichimura Koichi、Kawai Akira、Yoshida Akihiko
    • Journal Title

      Histopathology

      Volume: 82 Issue: 6 Pages: 937-945

    • DOI

      10.1111/his.14882

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiological precursor lesions of lung squamous cell carcinoma: Early progression patterns and divergent volume doubling time between hilar and peripheral zones2023

    • Author(s)
      Sugawara Haruto、Yatabe Yasushi、Watanabe Hirokazu、Akai Hiroyuki、Abe Osamu、Watanabe Shun-ichi、Kusumoto Masahiko
    • Journal Title

      Lung Cancer

      Volume: 176 Pages: 31-37

    • DOI

      10.1016/j.lungcan.2022.12.007

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome‐wide association and whole genome sequencing analyses2023

    • Author(s)
      Shiraishi Kouya、Takahashi Atsushi、、et al.
    • Journal Title

      Cancer Communications

      Volume: 44 Issue: 2 Pages: 287-293

    • DOI

      10.1002/cac2.12498

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population2023

    • Author(s)
      Shi Jianxin、Shiraishi Kouya、et al.
    • Journal Title

      Nature Communications

      Volume: 14 Issue: 1 Pages: 3043-3043

    • DOI

      10.1038/s41467-023-38196-z

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molecular pathology quality control in Southeast Asia: Results of a multiregional quality assurance study from MASTER KEY Asia2023

    • Author(s)
      Okuma Hitomi Sumiyoshi、Yoshida Hiroshi、Kobayashi Yoshihisa、Arakaki Motoko、Mizoguchi Chiharu、Inagaki Lina、Voon Pei Jye、Malik Bin Ismail Adam、Fen Soo Hoo Hwoei、Yusak Suhana、Severino B. Imasa Marcelo、Nguyen Huy Thinh、Thai Anh Tu、Kohsaka Shinji、Mano Hiroyuki、Yonemori Kan、Nakamura Kenichi、Yatabe Yasushi
    • Journal Title

      Cancer Science

      Volume: in press Issue: 6 Pages: 2664-2673

    • DOI

      10.1111/cas.15790

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reply to the Letter to the Editor From He Y et al2023

    • Author(s)
      Okubo Y. and Yatabe Y.
    • Journal Title

      J Thorac Oncol

      Volume: 18 Issue: 5 Pages: e46-e48

    • DOI

      10.1016/j.jtho.2023.02.006

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Strategic Approach to Heterogeneity Analysis of Cutaneous Adnexal Carcinomas Using Computational Pathology and Genomics2023

    • Author(s)
      Nishimura Yuuki、Ryo Eijitsu、Inoue Satoshi、Kawazu Masahito、Ueno Toshihide、Namikawa Kenjiro、Takahashi Akira、Ogata Dai、Yoshida Akihiko、Yamazaki Naoya、Mano Hiroyuki、Yatabe Yasushi、Mori Taisuke
    • Journal Title

      JID Innovations

      Volume: 3 Issue: 6 Pages: 100229-100229

    • DOI

      10.1016/j.xjidi.2023.100229

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Concordance between cryobiopsy and forceps biopsy specimens in assessment of immunohistochemistry staining for non-small cell lung carcinoma2023

    • Author(s)
      Nishimatsu K., Matsumoto Y., Kashima J., Imabayashi T., Uchimura K., Furuse H., ...Yatabe Y.
    • Journal Title

      Transl Lung Cancer Res

      Volume: 12 Issue: 6 Pages: 1245-1255

    • DOI

      10.21037/tlcr-22-621

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors2023

    • Author(s)
      Naito Y., Mishima S., Akagi K., Hayashi N., Hirasawa A., Hishiki T., ...Baba E.
    • Journal Title

      Int J Clin Oncol

      Volume: 28 Issue: 7 Pages: 827-840

    • DOI

      10.1007/s10147-023-02345-7

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamics of recurrence after curative resection of nonsmall cell lung cancer2023

    • Author(s)
      Muraoka Y., Yotsukura M., Yoshida Y., Nakagawa K., Shiraishi K., Kohno T., ...Watanabe S. I.
    • Journal Title

      J Surg Oncol

      Volume: 128 Issue: 7 Pages: 1205-1212

    • DOI

      10.1002/jso.27395

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Promoter swapping of truncated PDGFRB drives Ph-like acute lymphoblastic leukemia2023

    • Author(s)
      Miyazaki Bunpei、Ueno Toshihide、Sugiyama Masanaka、Kojima Shinya、Arakawa Ayumu、Tao Kayoko、Tanimura Kazuki、Shiraishi Kouya、Yagishita Shigehiro、Kohsaka Shinji、Kato Mamoru、Kiyokawa Nobutaka、Goto Yasushi、Yatabe Yasushi、Hamada Akinobu、Mano Hiroyuki、Ogawa Chitose、Tanaka Yosuke
    • Journal Title

      npj Precision Oncology

      Volume: 7 Issue: 1 Pages: 132-132

    • DOI

      10.1038/s41698-023-00485-7

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expert Consensus Recommendations on Biomarker Testing in Metastatic and Nonmetastatic NSCLC in Asia2023

    • Author(s)
      Mitsudomi Tetsuya、Tan Daniel、Yang James Chih-Hsin、Ahn Myung-Ju、Batra Ullas、Cho Byoung-Chul、Cornelio Gerardo、Lim Tony、Mok Tony、Prabhash Kumar、Reungwetwattana Thanyanan、Ren Sheng-Xiang、Singh Navneet、Toyooka Shinichi、Wu Yi-Long、Yang Pan-Chyr、Yatabe Yasushi
    • Journal Title

      Journal of Thoracic Oncology

      Volume: 18 Issue: 4 Pages: 436-446

    • DOI

      10.1016/j.jtho.2022.10.021

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of immunotherapy in patients with high tumor mutational burden tumors2023

    • Author(s)
      Mishima S., Naito Y., Akagi K., Hayashi N., Hirasawa A., Hishiki T., ...Baba E.
    • Journal Title

      Int J Clin Oncol

      Volume: 28 Issue: 8 Pages: 941-955

    • DOI

      10.1007/s10147-023-02360-8

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of immunotherapy in patients with DNA mismatch repair deficient (dMMR) tumors, third edition2023

    • Author(s)
      Mishima S., Naito Y., Akagi K., Hayashi N., Hirasawa A., Hishiki T., ...Baba E.
    • Journal Title

      Int J Clin Oncol

      Volume: 28 Issue: 10 Pages: 1237-1258

    • DOI

      10.1007/s10147-023-02397-9

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] KRAS G12C in advanced NSCLC: Prevalence, co-mutations, and testing2023

    • Author(s)
      Lim T. K. H., Skoulidis F., Kerr K. M., Ahn M. J., Kapp J. R., Soares F. A. and Yatabe Y.
    • Journal Title

      Lung Cancer

      Volume: 184 Pages: 107293-107293

    • DOI

      10.1016/j.lungcan.2023.107293

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Frequent CD30 Expression in an Emerging Group of Mesenchymal Tumors With NTRK, BRAF, RAF1, or RET Fusions2023

    • Author(s)
      Kojima Naoki、Mori Taisuke、Motoi Toru、Kobayashi Eisuke、Yoshida Masayuki、Yatabe Yasushi、Ichikawa Hitoshi、Kawai Akira、Yonemori Kan、Antonescu Cristina R.、Yoshida Akihiko
    • Journal Title

      Modern Pathology

      Volume: 36 Issue: 4 Pages: 100083-100083

    • DOI

      10.1016/j.modpat.2022.100083

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genome Doubling Shapes High-Grade Transformation and Novel EWSR1::LARP4 Fusion Shows SOX10 Immunostaining in Hyalinizing Clear Cell Carcinoma of Salivary Gland2023

    • Author(s)
      Kobayashi Kenya、Kawazu Masahito、Yoshimoto Seiichi、Ueno Toshihide、Omura Go、Saito Yuki、Ando Mizuo、Ryo Eigitsu、Sakyo Airi、Yoshida Akihiko、Yatabe Yasushi、Mano Hiroyuki、Mori Taisuke
    • Journal Title

      Laboratory Investigation

      Volume: 103 Issue: 10 Pages: 100213-100213

    • DOI

      10.1016/j.labinv.2023.100213

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A comprehensive appraisal of HER2 heterogeneity in HER2-amplified and HER2-low colorectal cancer2023

    • Author(s)
      Hashimoto Taiki、Takayanagi Daisuke、Yonemaru Junpei、Naka Tomoaki、Nagashima Kengo、Machida Erika、Kohno Takashi、Yatabe Yasushi、Kanemitsu Yukihide、Hamamoto Ryuji、Takashima Atsuo、Shiraishi Kouya、Sekine Shigeki
    • Journal Title

      British Journal of Cancer

      Volume: 129 Issue: 7 Pages: 1176-1183

    • DOI

      10.1038/s41416-023-02382-z

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Whole-genome sequencing reveals the molecular implications of the stepwise progression of lung adenocarcinoma2023

    • Author(s)
      Haga Y, Sakamoto Y, Kajiya K, Kawai H, Oka M, Motoi N, Shirasawa M, Yotsukura M, Watanabe S, Arai M, Zenkoh J, Shiraishi K, Seki M, Kanai A, Shiraishi Y, Yatabe Y, Matsubara D, Suzuki Y, Noguchi M, Kohno T, Suzuki A.
    • Journal Title

      Nature Communications

      Volume: 14 Issue: 1 Pages: 8375-8375

    • DOI

      10.1038/s41467-023-43732-y

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of vasculogenic mesenchymal tumor in the mediastinum: whole-exome sequencing reveals origin from pre-existing germ cell tumor2023

    • Author(s)
      Fujii Hirotake、Yamada Yosuke、Yamamura Kentaro、Ishida Yoshihiro、Tsujimura Marina、Matsumoto Kazuhisa、Tanaka Satona、Date Hiroshi、Nishikawa Tadaaki、Yoshida Yukihiro、Kashima Jumpei、Yatabe Yasushi、Ogawa Seishi、Marx Alexander、Ulbright Thomas M.、Haga Hironori
    • Journal Title

      Virchows Archiv

      Volume: 未定 Issue: 5 Pages: 923-927

    • DOI

      10.1007/s00428-023-03529-2

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clinical and pathological features of second primary neoplasms arising in head and neck reconstructive skin flaps2023

    • Author(s)
      Eguchi Kohtaro、Kobayashi Kenya、Honma Yoshitaka、Ryo Eijitsu、Sakyo Airi、Yokoyama Kazuki、Watanabe Takane、Aihara Yusuke、Sakai Azusa、Matsumoto Yoshifumi、Sakai Toshihiko、Omura Go、Yatabe Yasushi、Yoshimoto Seiichi、Mori Taisuke
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 0-0

    • DOI

      10.1038/s41598-023-38122-9

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-Term Prognosis and Prognostic Indicators of Stage IA Lung Adenocarcinoma2022

    • Author(s)
      Yotsukura Masaya、Muraoka Yuji、Yoshida Yukihiro、Nakagawa Kazuo、Shiraishi Kouya、Kohno Takashi、Yatabe Yasushi、Watanabe Shun-ichi
    • Journal Title

      Annals of Surgical Oncology

      Volume: 30 Issue: 2 Pages: 851-858

    • DOI

      10.1245/s10434-022-12621-x

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] KLF4 c.A1322C Mutation Is a Consistent and Specific Genetic Feature of Raspberry-like Foveolar-type Adenoma of the Stomach2022

    • Author(s)
      Naka Tomoaki、Hashimoto Taiki、Yoshida Teruhiko、Yatabe Yasushi、Sekine Shigeki
    • Journal Title

      American Journal of Surgical Pathology

      Volume: 47 Issue: 4 Pages: 521-523

    • DOI

      10.1097/pas.0000000000002012

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sporadic and Familial Adenomatous Polyposis-associated Foveolar-type Adenoma of the Stomach2022

    • Author(s)
      Naka Tomoaki、Hashimoto Taiki、Cho Hourin、Tanabe Noriko、Yoshida Teruhiko、Yatabe Yasushi、Yoshikawa Takaki、Abe Seiichiro、Sekine Shigeki
    • Journal Title

      American Journal of Surgical Pathology

      Volume: 47 Issue: 1 Pages: 91-101

    • DOI

      10.1097/pas.0000000000001949

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fine‐needle biopsy with 19G needle is effective in combination with endoscopic ultrasound‐guided tissue acquisition for genomic profiling of unresectable pancreatic cancer2022

    • Author(s)
      Ikeda Go、Hijioka Susumu、Nagashio Yoshikuni、...、Yatabe Yasushi、...
    • Journal Title

      Digestive Endoscopy

      Volume: 35 Issue: 1 Pages: 124-133

    • DOI

      10.1111/den.14423

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Presentation] Optimizing the approaches to detect MET alterations in advanced NSCLC: The role of NGS-based molecular testing. Focus on Targeting MET Alterations in Advanced NSCLC: A Webinar for Asian Physicians2023

    • Author(s)
      Yasushi Yatabe
    • Organizer
      ACE Oncology Web Semina
    • Related Report
      2023 Annual Research Report
  • [Presentation] Adjuvant Trials in NSCLC ? What Does This Mean for Pathology/Biomarkers.2023

    • Author(s)
      Yasushi Yatabe
    • Organizer
      World Conference of Lung Cancer 2023
    • Related Report
      2023 Annual Research Report
  • [Presentation] The Future of Biomarkers in Immunotherapy2023

    • Author(s)
      Yasushi Yatabe
    • Organizer
      World Conference of Lung Cancer 2023
    • Related Report
      2023 Annual Research Report
  • [Presentation] がんの病理組織を用いた空間解析最前線2023

    • Author(s)
      谷田部恭
    • Organizer
      第82回日本癌学会学術総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 厚労省・PMDA 、日本癌治療学会、日本臨床腫瘍学会共催ワークショップ 「CDx 制度の成熟と現在の問題」.2023

    • Author(s)
      谷田部恭
    • Organizer
      第64回日本肺癌学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Molecular Landscape of Mucinous Carcinoma. Novel Omics in Lung Cancer2023

    • Author(s)
      Yasushi Yatabe
    • Organizer
      Korean Lung Cancer Conference
    • Related Report
      2023 Annual Research Report

URL: 

Published: 2023-04-18   Modified: 2024-12-25  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi