Fundamental Research Toward Preemptive Medicine Development for Placental Insufficiently

Research Project

Project/Area Number	23K27736
Project/Area Number (Other)	23H03045 (2023)
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Multi-year Fund (2024) Single-year Grants (2023)
Section	一般
Review Section	Basic Section 56040:Obstetrics and gynecology-related
Research Institution	Kumamoto University
Principal Investigator	近藤英治熊本大学, 大学院生命科学研究部(医), 教授 (10544950)
Co-Investigator(Kenkyū-buntansha)	山口宗影熊本大学, 病院, 講師 (20626535) 小寺千聡熊本大学, 病院, 助教 (80879940)
Project Period (FY)	2023-04-01 – 2026-03-31
Project Status	Granted (Fiscal Year 2024)
Budget Amount *help	¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000) Fiscal Year 2025: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000) Fiscal Year 2024: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000) Fiscal Year 2023: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords	placentation / epigenetic clock / preemptive medicine / preeclampsia / fetal growh
Outline of Research at the Start	１）正常妊娠の胎盤形成期（妊娠11-15週）における胎盤のEpigenetic Clockのリファレンス（基準）を確立する。２）胎盤形成期の絨毛におけるエピゲノム制御異常（Epigenetic Clockの加速）と胎盤関連妊娠合併症の関与を明らかにする。