| Project/Area Number |
23K28389
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| Project/Area Number (Other) |
23H03700 (2023)
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Multi-year Fund (2024)
Single-year Grants (2023) |
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| Section | 一般 |
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| Review Section |
Basic Section 90030:Cognitive science-related
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| Research Institution | Kyoto University |
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Principal Investigator |
CHEN Chih・Yang 京都大学, 高等研究院, 特定助教 (30884689)
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| Project Period (FY) |
2023-04-01 – 2027-03-31
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| Project Status |
Granted (Fiscal Year 2024)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2026: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2025: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2024: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2023: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | marmoset / innate fear |
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| Outline of Research at the Start |
Although innate and conditioned fear are fundamentally different, they are difficult to distinguish. This proposal is to disting
uish them by focusing on the neural processing before entering amygdala, especially in the early sensory areas at neural level a
nd monitor the pupil response together with bio-physical emotion signals at behavior level to differentiate the two types of fea
r.
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| Outline of Annual Research Achievements |
Innate fear is a negative emotion that is genetically defined to promote animals’ survival. Conditioned fear can be relieved by fear extinction training but innate fear cannot. This leads to around 10%of the patients with anxiety disorders resistant to extinction treatment. The objective of my research is to distinguish innate and conditioned fears by focusing on the neural processing in the early sensory areas at the neural level, by analyzing brain-wide activities and traveling brain waves while the marmosets performing visual fear task, and at the behavioral level, by monitoring the pupil response and blood pressure. I hope to elucidating the cortical dynamic processing of visual innate or conditioned fear and indicating potential cortical targets for patients with anxiety disorders.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
My original plan was to finished the ECoG recording of the first marmoset ECoG and start to establish a ECoG data analysis pipeline using Graph theory. I would also perform the same task on human subjects to see if human exhibits similar differential pupil responses to marmosets. I have indeed finished the ECoG recording for the first marmoset and implanted the ECoG to the second marmoset. But the human recording was delayed due to the lack of human subjects. To compensate with this, I have finished developing the analysis pipeline and is now writing a manuscript to describe the method. Overall, I think I am progressing rather smoothly.
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| Strategy for Future Research Activity |
In 2024, I will implant bio-physiological recording devices (for measuring heart rate and blood pressure) in three marmosets to monitor their emotional change while they perform the visual fear task. I will also continue to collect ECoG data for the second marmoset. To also confirm that the same response could happen to human subjects, I will record the pupil response of human subjects while they are performing the same task. The method paper would be also published within year 2024.
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