| Project/Area Number |
23K28429
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| Project/Area Number (Other) |
23H03740 (2023)
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Multi-year Fund (2024)
Single-year Grants (2023) |
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| Section | 一般 |
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| Review Section |
Basic Section 90120:Biomaterials-related
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| Research Institution | Kyushu University |
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Principal Investigator |
LI JUNJIE 九州大学, 先導物質化学研究所, 准教授 (80869892)
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| Co-Investigator(Kenkyū-buntansha) |
田中 賢 九州大学, 先導物質化学研究所, 教授 (00322850)
小林 慎吾 九州大学, 先導物質化学研究所, 特任准教授 (70625110)
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| Project Period (FY) |
2023-04-01 – 2026-03-31
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| Project Status |
Granted (Fiscal Year 2024)
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| Budget Amount *help |
¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2025: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2024: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2023: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Keywords | enzyme delivery / polymer / oxidation therapy / nanoreactor / polymer-enzyme conjugate / safety/efficacy / stimuli-responsiveness / nano-bio interaction |
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| Outline of Research at the Start |
This polymer delivery system can synchronize long circulation in blood, precise clearance and degradation by macrophage, and enzyme activation in tumor. The key points are to control hydrophilic-hydrophobic balance and number of modified polymers to enable (i) long blood circulation and macrophage-tropism together and (ii) degradation of enzyme before activation in macrophage.
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| Outline of Annual Research Achievements |
This proposal aims to develop a simple delivery system for enzyme therapy. This polymer delivery system can synchronize long circulation in blood, precise clearance and degradation by macrophage, and enzyme activation in tumor. Some polymers have been prepared for enzyme delivery. We have tried to encapsulate the enzyme (such as glucose oxidase) and evaluated the cytotoxicity. We have performed some preliminary experiments for in vivo blood circulation and toxicity.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
The project progress smoothly.
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| Strategy for Future Research Activity |
We will perform the detailed cell experiments (such as cytotoxicity) and in vivo animal experiments (such as blood circulation, biodistribution, safety, and antitumor effect).
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