Project/Area Number |
23KF0010
|
Research Category |
Grant-in-Aid for JSPS Fellows
|
Allocation Type | Multi-year Fund |
Section | 外国 |
Review Section |
Basic Section 49050:Bacteriology-related
|
Research Institution | University of Tsukuba |
Principal Investigator |
森川 一也 筑波大学, 医学医療系, 教授 (90361328)
|
Co-Investigator(Kenkyū-buntansha) |
FERNANDES PEDRO 筑波大学, 医学医療系, 外国人特別研究員
|
Project Period (FY) |
2023-04-25 – 2025-03-31
|
Project Status |
Granted (Fiscal Year 2023)
|
Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2024: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2023: ¥1,000,000 (Direct Cost: ¥1,000,000)
|
Outline of Research at the Start |
This research aims at characterizing the subpopulation of Staphylococcus aureus that express competence genes (DNA incorporation machinery required for natural transformation), in terms of the cell cycle and tolerant to antibiotics. We plan expression alalysis of several genes under the controls of the regulators termed two-component regulatory systems (TCSs), whose deletion was shown to interfere with competence development. Fluorescence microscopy and FACS analysis will clarify if competence-related genes are part of their regulatory network.
|