| Project/Area Number |
23KF0016
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Multi-year Fund |
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| Section | 外国 |
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| Review Section |
Basic Section 56020:Orthopedics-related
|
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| Research Institution | The University of Tokyo |
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Principal Investigator |
高柳 広 東京大学, 大学院医学系研究科(医学部), 教授 (20334229)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
SHI TIANSHU 東京大学, 大学院医学系研究科(医学部), 外国人特別研究員
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|---|
| Project Period (FY) |
2023-04-25 – 2025-03-31
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| Project Status |
Granted (Fiscal Year 2023)
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| Budget Amount *help |
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 2024: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2023: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Outline of Research at the Start |
Bone functions as an endocrine organ secreted “osteokines” to regulate the homestasis of extraosseous organs under pathological conditions. Although osteoporosis patients exhibited a higher risk of Alzheimer's disease (AD), the explicit mechanism of bone-brain axial regulation was elusive. Here, we aim to demonstrate the existence of bone-immunology-brain systems which may be involved in the AD progress, which paved a brand-new way for therapeutic intervention in AD patients with several osteoporosis.
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